The predictive value of lymphocyte-to-monocyte ratio in the prognosis of acute coronary syndrome patients: a systematic review and meta-analysis

Quan, Xiao‐Qing; Wang, Run-Chang; Zhang, Qing; Zhang, Cuntai; Sun, Lei

doi:10.1186/s12872-020-01614-x

Cited by 29 publications

(27 citation statements)

References 31 publications

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“…4 C ), but none of these were significantly different between AIS grades. We also used these inferred proportions to calculate leukocyte ratios, which have been proven clinically useful in multiple diseases and traumas ( Choi et al, 2020 ; Quan et al, 2020 ; Zhao et al, 2020 ). The neutrophil-to-lymphocyte and the lymphocyte-to-monocyte ratios were both significantly different between the three groups (one-way ANOVA P values 0.0009 and 0.0273, respectively; Fig.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic blood RNA profiles for human acute spinal cord injury

Kyritsis

Torres-Espín

Schupp

et al. 2021

Journal of Experimental Medicine

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Diagnosis of spinal cord injury (SCI) severity at the ultra-acute stage is of great importance for emergency clinical care of patients as well as for potential enrollment into clinical trials. The lack of a diagnostic biomarker for SCI has played a major role in the poor results of clinical trials. We analyzed global gene expression in peripheral white blood cells during the acute injury phase and identified 197 genes whose expression changed after SCI compared with healthy and trauma controls and in direct relation to SCI severity. Unsupervised coexpression network analysis identified several gene modules that predicted injury severity (AIS grades) with an overall accuracy of 72.7% and included signatures of immune cell subtypes. Specifically, for complete SCIs (AIS A), ROC analysis showed impressive specificity and sensitivity (AUC: 0.865). Similar precision was also shown for AIS D SCIs (AUC: 0.938). Our findings indicate that global transcriptomic changes in peripheral blood cells have diagnostic and potentially prognostic value for SCI severity.

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Section: Resultsmentioning

confidence: 99%

Diagnostic blood RNA profiles for human acute spinal cord injury

Kyritsis

Torres-Espín

Schupp

et al. 2021

Journal of Experimental Medicine

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“…In last meta-analysis, with enrolment of 5 studies comprising 4343 patients to investigate the prognostic value of the LMR in patients with ACS, lower LMR was associated with higher long-term mortality/MACE in patients with ACS [9]. No difference in LMR parameters between patients with ACS and healthy persons was observed in our trial.…”

Section: Introductionmentioning

confidence: 62%

White Blood Cells Ratios in Patients With Acute Coronary Syndromes in Association With Hypertension and Diabetes Mellitus

Alghzawi

2021

RS Global - Science Review

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Introduction. Evidence now indicates that inflammation contributes considerably to the initiation and progression of atherosclerosis and an active inflammatory processes may trigger plaque rupture and enhance the risk of coronary thrombosis leading to a clinical ischemic event. The purpose of this study was to evaluate of white blood cells ratios in patients with ACS in association with arterial hypertension and 2 type Diabetes Mellitus. Material and Methods. In this observational cohort trial we observed of 184 patients with ACS. All patients were randomized into four groups: 1st group - 42 patients with ACS without AH or DM; 2nd group – 56 patients with ACS and previous AH; 3rd group – 42 patients with ACS and 2 type DM; and 4th group – 44 patients with ACS and AH and DM. We studied of leukocytes count and their subpopulation ratios: neutrophils to lymphocytes ratio (NLR), neutrophils to monocytes ratio (NMR), neutrophils to lymphocytes+monocytes ratio (N/LMR), lymphocytes to monocytes ratio (NMR). Results. The mean white blood cells count was significant higher in patients with ASC, compared with control group (p<0.001). In patients with ACS the elevated NMR and NLR were observed: 15.04±1.28 vs 11.09±0.43 in control group (p<0.05), and 3.34±0.20 vs 2.60±0.06 (p<0.05), respectively. No significant differences between WBC ratios were revealed in observed patients with ACS with or without AH and/or DM. Conclusion. ACS is characterized of raised NLR and NMR which could be indicators of poor prognosis.

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“…Because the LMR combines two kinds of immune cells, it has long been used as an indicator of the condition and treatment of cancer patients [ 22 , 23 ]. In recent years, studies have shown that the LMR is related to stable angina [ 17 , 18 ], acute coronary syndrome (ACS) [[[[ 24 ]]]] and CSF [ 6 ], and it can even be used as an independent predictor of major adverse cardiac events (MACEs) [ 20 , 21 , 24 ]. Yildirim et al [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Association of the lymphocyte-to-monocyte ratio, mean diameter of coronary arteries, and uric acid level with coronary slow flow in isolated coronary artery ectasia

Yang

Yuan

Cui

et al. 2021

BMC Cardiovasc Disord

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Background The pathophysiology of isolated coronary artery ectasia (CAE) with the coronary slow flow (CSF) phenomenon is still unclear. The purpose of this study was to investigate the risk factors for isolated CAE complicated with CSF. Methods A total of 126 patients with isolated CAE were selected retrospectively. The patients were grouped into the no CSF (NCSF) group (n = 55) and the CSF group (n = 71) according to the corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). Data on demographics, laboratory measurements, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd), CTFC and diameters of three coronary arteries were collected. Results The proportions of males (84.5% vs. 61.8%, p = 0.004) and patients with a smoking history (63.4% vs. 43.6%, p = 0.021) were higher in the CSF group than in the NCSF group. The neutrophil-to-lymphocyte ratio (NLR) (2.08(1.68–3.21) vs. 1.89 ± 0.58, p = 0.001), mean diameter of coronary arteries (mean D) (5.50 ± 0.85 vs. 5.18 ± 0.91, p < 0.001), and uric acid (URIC) level (370.78 ± 109.79 vs. 329.15 ± 79.71, p = 0.019) were significantly higher in the CSF group, while the lymphocyte-to-monocyte ratio (LMR) (4.81 ± 1.66 vs. 5.96 ± 1.75, p < 0.001) and albumin (ALB) level (44.13 ± 4.10 vs. 45.69 ± 4.11, p = 0.036) were lower. Multivariable logistic analysis showed that the LMR (odds ratio: 0.614, 95% CI: 0.464–0.814, p = 0.001), mean D (odds ratio: 2.643, 95% CI: 1.54–4.51, p < 0.001) and URIC level (odds ratio: 1.006, 95% CI: 1.001–1.012, p = 0.018) were independent predictors of CSF in CAE. Conclusions The LMR was a negative independent predictor of CSF in isolated CAE, while URIC level and mean D were positive independent predictors.

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The predictive value of lymphocyte-to-monocyte ratio in the prognosis of acute coronary syndrome patients: a systematic review and meta-analysis

Cited by 29 publications

References 31 publications

Diagnostic blood RNA profiles for human acute spinal cord injury

Diagnostic blood RNA profiles for human acute spinal cord injury

White Blood Cells Ratios in Patients With Acute Coronary Syndromes in Association With Hypertension and Diabetes Mellitus

Association of the lymphocyte-to-monocyte ratio, mean diameter of coronary arteries, and uric acid level with coronary slow flow in isolated coronary artery ectasia

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