The Predictive Value of Red Blood Cell Distribution Width for Survival Outcomes of Metastatic Renal Cell Carcinoma Patients Treated with Targeted Therapy

Aktepe, Oktay Halit; Güven, Deniz Can; Şahin, Taha Koray; Yıldırım, Hasan Çağrı; Çelikten, Burcu; Yeter, Haci Hasan; Yüce, Deniz; Dizdar, Ömer; Erman, Mustafa

doi:10.1080/01635581.2021.1871925

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Aktepe OH et al. revealed that a high RDW level was significantly associated with worse survival outcomes in patients with metastatic kidney cell carcinoma treated with targeted therapy [ 32 ]. Zou et al.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width at admission predicts outcome in critically ill patients with kidney failure: a retrospective cohort study based on the MIMIC-IV database

2022

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Purpose We aimed to explore whether red blood cell distribution width (RDW) could serve as a biomarker to predict outcomes in critically ill patients with kidney failure in this study. Materials and methods This retrospective study was conducted with the Medical Information Mart for Intensive Care IV (MIMIC-IV).A total of 674 patients were divided into three groups based on tertiles of RDW. We used the generalized additive model, Kaplan–Meier curve, and Cox proportional hazards models to evaluate the association between RDW and clinical outcomes. We then performed subgroup analyses to investigate the stability of the associations between RDW and all-cause mortality. Results Nonlinear and J-shaped curves were observed in the generalized additive model. Kaplan–Meier analysis showed that patients with elevated RDW had a lower survival rate. The Cox regression model indicated that high levels of RDW were most closely associated with ICU mortality and 30-day mortality (HR = 4.71, 95% CI: 1.69–11.64 and HR = 6.62, 95% CI: 2.84–15.41). Subgroup analyses indicated that the associations between RDW and all-cause mortality were stable. Conclusions Elevated levels of RDW were associated with an increased risk of all-cause mortality, and RDW could be an independent prognostic factor for kidney failure.

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Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width at admission predicts outcome in critically ill patients with kidney failure: a retrospective cohort study based on the MIMIC-IV database

2022

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“…Aktepe et al. also demonstrated the predictive power of RDW in metastatic renal cancer receiving targeted therapy [23] . However, only 104 patients were included in their study, whereas our study included 230 patients.…”

Section: Discussionmentioning

confidence: 96%

Preoperative red blood cell distribution width as an independent prognostic factor in metastatic renal cell carcinoma

Wei

Zhang

et al. 2022

Translational Oncology

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“…Their study revealed that patients with high RDW level had inferior PFS and OS than those with low RDW. 29 Our study evaluated a larger (301) cohort of patients with mRCC, treated with pazopanib (59%) or cabozantinib (41%). We determined a baseline RDW cut-off of 16% as the optimal value to maximize the log-rank test.…”

Section: Discussionmentioning

confidence: 99%

The role of mean corpuscular volume and red cell distribution width in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors: the MARECAP retrospective study

Tommasi

Scartabellati

Giannarelli

et al. 2023

Therapeutic Advances in Urology

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Background: Tyrosine-kinase inhibitors (TKIs) and immunotherapy represent the backbone treatment for metastatic renal cell carcinoma (mRCC) patients. The aim of the present study was to describe mean corpuscular volume (MCV) and red cell distribution width (RDW) in mRCC patients treated with pazopanib or cabozantinib, and to explore their potential impact on oncological outcomes. Materials and methods: We conducted a multicenter retrospective observational study in mRCC patients treated with pazopanib or cabozantinib between January 2012 and December 2020 in nine Italian centers. Descriptive statistics, univariate, and multivariate analyses were performed. Objectives: The primary endpoints were the incidence and trend over time of anemia, macrocytosis (elevated MCV), and anisocytosis (elevated RDW). The secondary endpoints were the correlations of MCV and RDW with objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Results: A total of 301 patients were enrolled; mean Hb value was 12.5 g/dl, a mean increase of 1 g/dl was observed at day 15 and maintained at 3 months. Most patients had baseline macrocytosis (MCV levels > 87 fl), with a significant mean increase after 3 months of treatment. At univariate analysis patients with macrocytosis had better ORR, longer PFS, and OS. About one third of patients had baseline anisocytosis (RDW > 16%), with a significant mean increase after 3 months of treatment. At univariate analysis, patients with RDW values ⩽ 16% had higher ORR, longer PFS, and OS. At multivariate analysis, baseline macrocytosis was significantly associated with better PFS in patients treated with pazopanib and baseline anisocytosis with shorter OS in all patients. Conclusions: mRCC patients treated with pazopanib or cabozantinib may have baseline macrocytosis and anisocytosis. A significant increase of Hb, MCV, and RDW after TKIs start was observed. Baseline macrocytosis is positively correlated with PFS in patients treated with pazopanib and baseline anisocytosis affects survival of patients treated with TKIs.

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The Predictive Value of Red Blood Cell Distribution Width for Survival Outcomes of Metastatic Renal Cell Carcinoma Patients Treated with Targeted Therapy

Cited by 8 publications

References 26 publications

Red blood cell distribution width at admission predicts outcome in critically ill patients with kidney failure: a retrospective cohort study based on the MIMIC-IV database

Red blood cell distribution width at admission predicts outcome in critically ill patients with kidney failure: a retrospective cohort study based on the MIMIC-IV database

Preoperative red blood cell distribution width as an independent prognostic factor in metastatic renal cell carcinoma

The role of mean corpuscular volume and red cell distribution width in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors: the MARECAP retrospective study

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