The Predictive Value of Serum Angiotensin Converting Enzyme and Lysozyme Levels in the Diagnosis of Ocular Sarcoidosis

Baarsma, G. S.; Hey, Ellen; Glasius, E.; Vries, J. de; Kijlstra, Aize

doi:10.1016/0002-9394(87)90406-5

Cited by 91 publications

(39 citation statements)

References 10 publications

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“…However, with a sensitivity of 84% and 60%, respectively, the ACE and lysozyme tests result in a high proportion of false negatives among sarcoid uveitis patients. 26 Blau syndrome is caused by mutations in the autosomal dominant NOD2 gene 27 and is often characterized by both an anterior and posterior uveitis. 16 None of the patients in our series had posterior uveitis, making Blau syndrome less likely, although NOD2 gene analysis was not undertaken.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous inflammation in juvenile idiopathic arthritis–associated uveitis

Keenan

Tessler

Goldstein

2008

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionmentioning

confidence: 99%

Granulomatous inflammation in juvenile idiopathic arthritis–associated uveitis

Keenan

Tessler

Goldstein

2008

Journal of American Association for Pediatric Ophthalmology and

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“…However, both CT chest scans and gallium scintigraphy are helpful to pinpoint sites for biopsy. Serum ACE tends to be increased in about half of untreated patients, but the sensitivity and predictive value are not optimal (Baarsma et al 1987). Serum ACE levels can be elevated in infection, diabetes mellitus, malignancy and other pathological conditions.…”

Section: Discussionmentioning

confidence: 99%

Neuro‐ophthalmological findings in sarcoidosis

Heuser

Kerty

2004

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: This review emphasizes the importance of neuro-ophthalmological signs and symptoms in sarcoidosis. The presence of ophthalmological and neuro-ophthalmological findings may lead to diagnosis of the disease and the initiation of adequate treatment. Material and Methods: Patients who had been diagnosed with neurosarcoidosis during the period 1990 À 2001 were identified from the departmental diagnostic index. The history, clinical, laboratory and imaging data of patients were analysed. Results: Fifteen patients were identified, four men and 11 women, with a mean age of 44.1 years (range 26-65 years). In six of the 15 (40%), neurological deficits were the initial symptoms. Nine (60%) had known sarcoidosis at the time of presentation. Ten patients (66%) had ophthalmological/neuro-ophthalmological symptoms and signs. Conclusion: Neuro-ophthalmological symptoms may develop early in neurosarcoidosis. If neuro-ophthalmological symptoms arise in patients with established biopsyproven sarcoidosis, the diagnosis is usually easy to make. However, a number of patients with neurosarcoidosis may present with neuro-ophthalmic symptoms before systemic involvement becomes obvious. In this situation the diagnosis is challenging, and the major goal is to establish the presence of systemic sarcoidosis.

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“…However, a diagnosis of presumed sarcoidosis can be made based on compatible ophthalmological features in association with chest imaging fi ndings and/or raised serum angiotensin converting enzyme (ACE). In one large series of patients with uveitis, elevated serum ACE levels were found to have a sensitivity of 84% and a specifi city of 95% [ 8 ].…”

Section: Sarcoidosismentioning

confidence: 99%

Intraocular inflammation: Its causes and investigations

Hooper¹,

McCluskey²

2008

Curr Allergy Asthma Rep

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Intraocular inflammation, or uveitis, incorporates a diverse group of infectious and immune-mediated disorders. In addition, some conditions masquerade as uveitis. However, classifying uveitis according to anatomic location in adult and pediatric populations, and appreciating the effect of immune status and regional differences, refines the list of potential causes. In this way, a select few investigations can be performed, rather than a nondirected battery of tests.

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The Predictive Value of Serum Angiotensin Converting Enzyme and Lysozyme Levels in the Diagnosis of Ocular Sarcoidosis

Cited by 91 publications

References 10 publications

Granulomatous inflammation in juvenile idiopathic arthritis–associated uveitis

Granulomatous inflammation in juvenile idiopathic arthritis–associated uveitis

Neuro‐ophthalmological findings in sarcoidosis

Intraocular inflammation: Its causes and investigations

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