The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia

Darmochwał-Kolarz, Dorota; Kludka-Sternik, Magdalena; Tabarkiewicz, Jacek; Kolarz, Bogdan; Roliński, Jacek; Leszczyńska‐Gorzelak, Bożena; Oleszczuk, Jan

doi:10.1016/j.jri.2012.01.006

Cited by 219 publications

(210 citation statements)

References 33 publications

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“…It seems that an imbalance of Th17/Treg proportion is associated with recurrent pregnancy loss and pre-eclampsia. 48,49 Tolerance from the fetus toward the mother…”

Section: Tafurimentioning

confidence: 99%

Adaptive Immune Responses During Pregnancy

Zenclussen

2013

American J Rep Immunol

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It has long been believed that there is no immune interaction between mother and conceptus during pregnancy. This concept changed after evidence was provided that the maternal immune system is aware of the semiallogeneic conceptus and develops strategies to tolerate it. Since then, finely regulated mechanisms of active tolerance toward the fetus have been described. This Special Issue of the American Journal of Reproductive Immunology deals with these mechanisms. It begins with the description of minor histocompatibility antigens in the placenta; it further goes through adaptive immune responses toward paternal fetal antigens, mostly concentrating on regulatory T cells and molecules modulating the Th1/Th2 balance. The participation of antibody‐producing B cells in normal and pathological pregnancies is also discussed. This introductory chapter resumes the concepts presented throughout the Issue and discusses the clinical applications raised from these concepts.

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“…It seems that an imbalance of Th17/Treg proportion is associated with recurrent pregnancy loss and pre-eclampsia. 48,49 Tolerance from the fetus toward the mother…”

Section: Tafurimentioning

confidence: 99%

Adaptive Immune Responses During Pregnancy

Zenclussen

2013

American J Rep Immunol

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“…Dhillion et al observed increament of blood pressure after IL-17 infusion on pregnant rats [27]. Increased IL-17 producing T lymphocytes were observed in preeclamptic pregnants [6].…”

Section: Discussionmentioning

confidence: 98%

“…The abnormality in Th1/Th2 balance may initiate and intensify the cascade of inflammatory cytokine production involved in adverse pregnancy outcomes as spontaneous abortion, intrauterine growth restriction, PE and preterm delivery [2][3][4]. Besides the imbalance of Th1 and Th2 cells, alterations of the prevalence of Th17, regulatory T (Treg) cells, cytokine response systems (suppressor of cytokine signalling-SOCS) have also been suggested to contribute to pathogenesis of PE [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Özkan

Devici

Şi̇mşek

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives: Preeclampsia (PE) is associated with impaired decidual leukocyte and plasma cytokine balance compared with normal pregnancy. We aimed to investigate maternal plasma levels of Interferon-gamma (IFN-g), Tumor Necrosis Factor-alpha (TNF-a), Transforming Growth Factor-beta (TGF-b), Interleukin-4 (IL4), IL6, IL10, IL17, IL35, suppressor of Cytokine Signalling-3 (SOCS3) and placental bed leukocytes in preeclamptic and healthy pregnants. Materials & Methods:This study was conducted with 40 preeclamptic and 40 normotensive pregnants. Cytokine levels were studied with enzyme-linked immunosorbent assay. CD8, CD56 and CD163 antigens were analysed by immunohistochemical study on placental bed biopsies. Results:In preeclamptic women; IFN-g and TGF-b levels were significantly higher and IL-35 levels were significantly lower than those of controls. CD8, CD56 and CD163 positivity of preeclamptic group were not significantly higher than those of controls. CD8 staining showed negative correlation with plasma IL17 levels. CD163 staining showed negative correlation with TNF-a/IL4 ratio. TNF-a/IL4 ratio showed minimal influence on placental bed CD163 staining. Conclusion:Slightly increased placental bed CD8, CD56 and CD163 positive leukocytes and increased plasma IFN-g, TGF-b and decreased plasma IL35 levels of preeclamptic pregnants indicate an aberrant cell mediated immunity in PE. We could not say yet that this condition is whether result or reason. New studies are needed to discuss our results.

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“…As T reg cells increase in number, a concurrent opposing shift in the local immune cell population results in the suppression of Th17 switching, the overabundance of which has been correlated with preeclampsia [14]. Additional studies suggest that semen may further bias a type 2 response by inducing the production of type 2 cytokines from local and intraepithelial T cells and dendritic cells (DCs), possibly through semen-associated prostaglandins [15,16].…”

Section: Factors In Semen Modulate Immunity Essential To Establishingmentioning

confidence: 99%

Variability in human semen content and its potential effects in the female reproductive tract

Keogan¹,

Siegert²,

Wigdahl³

et al. 2016

J Reprod Biol Health

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Human semen is a complex medium containing high concentrations of cytokines, chemokines, and growth factors that play key roles in orchestrating immune responses during reproduction. These factors are essential to establishing conditions that facilitate fertilization and embryogenesis through modulation of local immune responses in the female reproductive tract. Typically, semen initiates a biphasic process of inflammation that is gradually resolved, leading to immune cell recruitment pivotal to clearing excess sperm and establishing tolerance of the fetal allograft. However, the identity and concentration of factors found in semenmay be altered in the male reproductive tract as a consequence of sexually transmitted infections and infertility conditions. As a result, imbalances in semen content can skew the secretory response of the cervicovaginal epithelium after deposition during heterosexual intercourse, which may distort local immune activity and lead to embryo rejection or enhanced pathogen transmission. Recognizing the array of factors contained in semen and the degree to which they vary is an essential part of understanding the impact of variations in semen content on reproductive biology and the transmission of sexually transmitted disease pathogens.

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The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia

Cited by 219 publications

References 33 publications

Adaptive Immune Responses During Pregnancy

Adaptive Immune Responses During Pregnancy

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Variability in human semen content and its potential effects in the female reproductive tract

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