The preferential accumulation of heavy metals in different tissues following frequent respiratory exposure to PM2.5 in rats

Abstract

This study aimed to explore the pattern of accumulation of some of main heavy metals in blood and various organs of rats after exposed to the atmospheric fine particulate matter (PM2.5). Rats were randomly divided into control and three treatment groups (tracheal perfusion with 10 mg/kg, 20 mg/kg and 40 mg/kg of PM2.5 suspension liquid, respectively). Whole blood and the lung, liver, kidney, and cerebral cortex were harvested after rats were treated and sacrificed. The used heavy metals were detected using inductively coupled plasma-mass spectrometry (ICP-MS) instrument. As results, Lead was increased in the liver, lung and cerebral cortex and the level of manganese was significantly elevated in the liver and cerebral cortex in PM2.5 treated rats. Besides, arsenic was prominently enriched both in cerebral cortex and in blood, and so did the aluminum in the cerebral cortex and the copper in the liver. However, cadmium, chromium and nickel have shown no difference between the control group and the three PM2.5 treated groups. Following the exposure of PM2.5, different heavy metals are preferentially accumulated in different body tissues.

Polydatin protects the respiratory system from PM2.5 exposure

“…The composition of PM 2.5 mainly consists of sulfate, nitrate, nitrogen salt and heavy metals10. Mesoporous silica nanoparticles (MSN) are advantageous for harboring the major chemical components of PM 2.5 because of their special structure with numerous small pores; these chemicals can adhere to the large inner surface of the pores11.…”

Biological and chemical hazards in water-mix metalworking fluids and mists

“…Additionally, the deeper into the respiratory system the particles travel; the longer it can take the body to clear them. In some circumstances, the particles cannot be broken down, and they persist in the body (Li et al, 2015). This is a term often referred to as bioaccumulation.…”

“…This is a term often referred to as bioaccumulation. When bioaccumulation occurs, this can potentiate the toxic effects of the metal (Li et al, 2015). Therefore, it is important to determine whether the metals in used MWF are likely to be represented in the mist.…”

“…However, in some circumstances the particles can persist and are not easily removed or broken down as fast as the body can eliminate them (Li et al, 2015). Therefore, some metals have potential to bioaccumulate in the bodily tissues, and therefore potentiate the toxic effects of the metals (Li et al, 2015). The diagram shows the transport of particles of different size through the respiratory system.…”

“…Clearance of the particles can occur through a variety of routes, for example, phagocytosis and translocation. However, in some circumstances the particles can persist and are not easily removed or broken down as fast as the body can eliminate them (Li et al, 2015). Therefore, some metals have potential to bioaccumulate in the bodily tissues, and therefore potentiate the toxic effects of the metals (Li et al, 2015).…”