The preoperative neutrophil–lymphocyte ratio predicts recurrence and survival among patients undergoing R0 resections of adenocarcinomas of the esophagogastric junction

Yuan, Dawei; Zhu, Kun; Li, Kang; Yan, Rong; Jia, Yong; Dang, Chengxue

doi:10.1002/jso.23651

Cited by 56 publications

(57 citation statements)

References 46 publications

(54 reference statements)

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“…The most common tumor site was the temporal lobe (37.2%), followed by the occipital lobe (27.5%). The mean tumor volume was 32.1 ± 27.3 cm 3 . In 19 cases (37.2%), the tumor was located close to a ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…[2,3] NLR is an inexpensive and widely available biomarker of glioblastoma aggressiveness, and thus should be used alongside current glioblastoma prognostic factors. Nevertheless, there is obviously a need for future studies with larger numbers of patients in order to confirm our preliminary observations.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Cancer-associated inflammation has been correlated with outcome in patients with cancer. [2][3][4] Among the various inflammation markers, the neutrophil-to-lymphocyte ratio (NLR) has been examined in a variety of cancers and has been found to be elevated in patients with more advanced or aggressive disease. [5][6][7][8] The exact mechanisms by which neutrophilia is induced by tumors is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of neutrophil-to-lymphocyte ratio in glioblastoma

Alexiou¹,

Vartholomatos²,

Zagorianakou³

et al. 2014

Neuroimmunol Neuroinflammation

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A B S T R A C T Aim:The neutrophil-to-lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. The purpose of this study was to investigate the prognostic value of NLR in patients with glioblastoma. Methods: A prospective study was conducted on patients receiving surgery for glioblastoma. Preoperative NLR was recorded and correlated with other prognostic factors and survival. Results: Fifty-one patients were included in the study. The mean NLR ratio was 6.7 ± 4.6. Using receiver operating characteristic curve analysis, an NLR cut-off value of 4.7 was determined to best predict survival. Patients with NLR ratios exceeding 4.7 differed significantly from those with NLR ratios ≤ 4.7 and were associated with reduced survival. Patients with gross total tumor excision had a median survival of 18 months, whereas the median survival time was 11 months in patients with subtotal tumor excision. No significant difference in survival was observed with respect to patient age, gender, Karnofsky performance status, or tumor location. Using multivariate analysis, NLR and extent of tumor resection were identified as factors with independent prognostic power. Conclusion: Neutrophil-to-lymphocyte ratio is an inexpensive, widely available biomarker of glioblastoma aggressiveness and should be used alongside current glioblastoma prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic significance of neutrophil-to-lymphocyte ratio in glioblastoma

Alexiou¹,

Vartholomatos²,

Zagorianakou³

et al. 2014

Neuroimmunol Neuroinflammation

View full text Add to dashboard Cite

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“…Additionally, some reports have been published to assess the prognostic role of NLR in the peripheral blood of patients with malignant diseases. An increased NLR is associated with poor, late prognosis of various malignancies, including pancreatic or oesophageal cancer [6,7]. Recently, NLR has also been evaluated as a predictor of major postoperative complications in abdominal surgery [8].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio and C-Reactive Protein as Two Predictive Tools of Anastomotic Leak in Colorectal Cancer Open Surgery

Mik¹,

Dziki²,

Berut³

et al. 2017

Dig Surg

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Purpose: To assess the prognostic value of postoperative C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in the development of anastomotic leak (AL) in patients after surgery for colorectal cancer (CRC). Methods: Patients operated on for CRC between 2010 and 2014 were enrolled into the study. The sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPVs) were calculated for the CRP and NLR measured on the 4th postoperative day (POD). Results: Among 724 patients, AL was diagnosed in 33 (4.6%). The accuracy of CRP in the detection of AL using area under curve was 0.83 with the optimal cut-off value of 180 mg/L, sensitivity 75%, specificity 91%, PPV 52% and NPV 87%. Also, NLR on POD4 was higher in the AL group: 9.03 ± 4.13 vs. 4.45 ± 2.25; p = 0.0012; sensitivity 69%, specificity 78%, PPV 49%, NPV 88% at cut-off point of 6.5. Moreover, CRP and NLR on POD4 were significantly higher in patients who died in the postoperative period: 239 ± 24 mg/L vs. 199 ± 41 mg/L; p = 0.034 and 10.71 ± 2.08 vs. 8.65 ± 4.67; p = 0.029, respectively). Conclusions: CRP and NLR on POD4 possess the ability to predict the development of AL and postoperative mortality after CRC operation. Based on our results, high NPV might be indicative of patients with low risk of AL in their postoperative period.

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“…Preoperative blood samples for neutrophil and lymphocyte counts are taken for almost all colorectal cancer patients, and the NLR can be simply calculated. It has been reported that NLR is a prognostic factor for various cancers, such as advanced cancer [9], pancreatic cancer [10], non-small cell lung cancer [11], cancer of esophagogastric junction [12], gastric cancer [13], lung cancer [14], and head and neck cancer [15]. Pre-treatment NLR has also been reported as a prognostic factor for colorectal cancer [16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of Preoperative Neutrophil‐to‐Lymphocyte Ratio in Colorectal Cancer

et al. 2016

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Background The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) has been reported in several cancers included colorectal cancer; however, it is not clear if there is an association between NLR and cancer-specific survival in colorectal cancer. And the optimal cut-off value is controversial. This study was designed to assess the prognostic value of preoperative NLR in colorectal cancer patients. Methods Total 823 consecutive patients who underwent surgery for all stages of colorectal cancer in our hospital between January 2006 and December 2011 were included in the study. Preoperative NLR was calculated from their hospital records. Results Using the receiver-operating characteristic curve, we found that the optimal preoperative NLR cut-off value that was strongly associated with cancer-specific survival was 2.1. Using this value, 505 patients were identified as having high NLR (C2.1) and 397 patients were identified as having low NLR (\2.1). High NLR was associated with preoperative serum albumin values \4.0 g/dl (p \ 0.001), positive preoperative serum C-reactive protein (CRP; p \ 0.001), preoperative carcinoembryonic antigen (CEA) values C5.0 ng/dl (p = 0.003), and stage progression (p = 0.002). Cox proportional hazard analyses identified preoperative high NLR as an independent poor prognostic factor (p = 0.020, HR 1.66 (95 % CI: 1.08-2.63)). When comparing stage of disease, preoperative high-NLR patients with Stage III disease (p = 0.024) and Stage IV disease (p = 0.036) had significantly poorer prognoses. Conclusions In this study, we have demonstrated that preoperative NLR C2.1 was a prognostic indicator for cancerspecific survival of colorectal cancer patients.

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The preoperative neutrophil–lymphocyte ratio predicts recurrence and survival among patients undergoing R0 resections of adenocarcinomas of the esophagogastric junction

Abstract: The present study indicates that elevated preoperative NLR (≥ 5) is a useful marker of tumor recurrence and independently predicts poorer disease-free and overall survival among patients with AEG undergoing R0 resections.

Cited by 56 publications

References 46 publications

Prognostic significance of neutrophil-to-lymphocyte ratio in glioblastoma

Prognostic significance of neutrophil-to-lymphocyte ratio in glioblastoma

Neutrophil to Lymphocyte Ratio and C-Reactive Protein as Two Predictive Tools of Anastomotic Leak in Colorectal Cancer Open Surgery

The Prognostic Value of Preoperative Neutrophil‐to‐Lymphocyte Ratio in Colorectal Cancer

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