The preparation of chiral carbon dots and the study on their antibacterial abilities

Zhao, Dan; Xu, Mengyu; Dai, Kang; Liu, Huan; Jiao, Yan; Xiao, Xincai

doi:10.1016/j.matchemphys.2022.127144

Cited by 19 publications

(8 citation statements)

References 48 publications

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“…In addition, Ch-CDs can achieve antibacterial and antibiofilm effects by selectively binding specifically to enzymes associated with the physiological activities of bacterial cells and inhibiting their activities without affecting the corresponding enzymes of the host. 103,104 As shown in Figure 6A, Xin et al 103 synthesized the chiral carbon nanodots dGG and lGG with D-Glu/L-Glu and graphene quantum dots (GQD). dGG penetrates the bacterial cell membrane and binds specifically to the cytoplasmic MurD ligase, inhibiting peptidoglycan (PG) synthase activity, leading to cell wall damage and subsequent leakage of cytoplasmic contents, ultimately killing the bacteria, as shown in Figure 6B.…”

Section: Drug Carriersmentioning

confidence: 99%

“…Researchers have utilized the chiral selectivity of Ch-CDs to design antibacterial agents that interact with specific enantiomers on the surface of the bacterial cell membrane or at intracellular chiral sites. In addition, Ch-CDs can achieve antibacterial and antibiofilm effects by selectively binding specifically to enzymes associated with the physiological activities of bacterial cells and inhibiting their activities without affecting the corresponding enzymes of the host. , …”

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

“…In addition to the antibacterial effect achieved by altering the secondary structure of MurD ligase, the antibacterial effect can also be achieved by inhibiting the MurA enzyme and thus interrupting the synthesis of PG. Zhao et al used one-step hydrothermal and two-step hydrothermal methods to synthesize Ch-CDs. D/LGU, D/LCS, N-CDs- d -Glu/N-CDs- l -Glu, and l -Cys-CDs/ d -Cys-CDs by modifying with l / d -glutamic acid ( l / d -Glu) and l / d -cysteine ( l / d -Cys).…”

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

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Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Chen,

Yu,

et al. 2023

ACS Biomater. Sci. Eng.

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The discovery of chiral carbon dots (Ch-CDs) has opened up an exciting new research direction in the field of carbon dots. It not only retains the chirality of the precursor and exhibits highly symmetric chiral optical properties but also has properties such as chemical stability, antibacterial and antitumor properties, and good biocompatibility of carbon dots. Based on these advantages, the application of Ch-CDs in the biomedical field has attracted significant interest among researchers. However, a comprehensive review of the selection of precursors for Ch-CDs, preparation methods, and applications in biomedical fields is still lacking. Here, we summarize their precursor selection and preparation methods based on recent reports on Ch-CDs and provide the first comprehensive review for specific applications in biomedical engineering, such as biosensing, bioimaging, drug carriers, antibacterial and antibiofilm, and enzyme activity modulation. Finally, we discuss application prospects and challenges that need to be overcome. We hope this review will provide valuable guidance for researchers to prepare novel Ch-CDs and facilitate their application in biomedical engineering.

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Section: Drug Carriersmentioning

confidence: 99%

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

Section: Application Of Ch-cds In Biomedical Engineeringmentioning

confidence: 99%

See 2 more Smart Citations

Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Chen,

Yu,

et al. 2023

ACS Biomater. Sci. Eng.

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“…The preparation of cCQDs was divided into one-step and two-step methods [23]. Zhao and his colleagues compared the antimicrobial activities of various cCQDs prepared using both one-step hydrothermal and two-step coupling methods [24]. cCQDs showed promising applications in the fields of targeted imaging [25], chiral catalysis [14], chiral recognition [26], and chiral detection [27].…”

Section: Introductionmentioning

confidence: 99%

One‐step hydrothermal preparation of chiral carbon quantum dots and enantioselective sensing of glutamine enantiomeric isomers

Li,

Wu,

Zhu

2023

Luminescence

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A novel method for chiral identification of glutamine enantiomers based on chiral carbon quantum dots (cCQDs) fluorescent probes. cCQDs were prepared using a one‐step hydrothermal method with L‐tryptophan as the carbon source and chiral source, producing spherical nanoparticles exhibiting a blue colour luminescence. The fluorescence intensity (F) of cCQDs was enhanced or quenched following the addition of chiral enantiomeric glutamine (L/D‐Gln), and therefore cCQDs, as a fluorescence probe, could be used for enantioselective sensing of the L/D‐Gln. The fluorescence enhancement value (∆FE) exhibited good linearity with L‐Gln concentration in the range 0.23–10.00 mM, and the limit of detection was 0.14 mM. The fluorescence quenching value (∆FQ) showed a good linear relationship with D‐Gln concentration in the range 0.29–10.00 mM, and the detection limit was 0.18 mM. The mechanism of fluorescence enhancement/quenching was explored by molecular modelling and the type of quenching. The method was applied to the determination of L‐Gln content in real samples, and the recovery rate was satisfactory. This study provided a novel approach for the synthesis of cCQDs and the recognition of amino acid enantiomers.

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D‐cysteine‐Derived Carbon Dots for Selective Discrimination, Imaging, and Synergistic Elimination of Gram‐Positive Bacteria and Fungi

Song,

Wang,

Nong

et al. 2024

Adv Funct Materials

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Microbial infections pose a significant threat to public health, exacerbated by the escalating issue of antibiotic resistance resulting from their overuse. Chiral carbon dots (CDs) not only inherit the antibacterial properties of CDs but also demonstrate highly selective chiral bactericidal activity. This study focuses on the development of chiral CDs synthesized from D‐ and L‐cysteine, to selectively identify and synergistically eradicate Gram‐positive bacteria and fungi. Chiral CDs exhibit high efficacy in staining Gram‐positive bacteria and fungi while demonstrating minimal to no fluorescence with Gram‐negative bacteria, attributable to variances in the membrane structures of these pathogens. D‐CDs exhibit stronger fluorescence signals and greater antibacterial efficacy against Gram‐positive bacteria and fungi compared to L‐CDs. Under dual light irradiation, D‐CDs bolster antibacterial activity through a triple‐modal mechanism, involving membrane disruption in the absence of light, singlet oxygen generation during photodynamic therapy, and elevated temperature during photothermal treatment. Animal studies additionally showcase that D‐CDs notably enhanced the healing of wounds infected with S. aureus under laser light exposure. This investigation underscores the chiral‐specific imaging and antibacterial potentials of D‐CDs, paving the way for the advancement of chiral nanomaterials in bacterial diagnostics and therapy.

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The preparation of chiral carbon dots and the study on their antibacterial abilities

Cited by 19 publications

References 48 publications

Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

Recent Progress on Chiral Carbon Dots: Synthetic Strategies and Biomedical Applications

One‐step hydrothermal preparation of chiral carbon quantum dots and enantioselective sensing of glutamine enantiomeric isomers

D‐cysteine‐Derived Carbon Dots for Selective Discrimination, Imaging, and Synergistic Elimination of Gram‐Positive Bacteria and Fungi

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