The Presence of a Gonadotropin-inhibiting Substance in Human Urine

Further studies on gonadotropin-inhibiting substances excreted in human urine.

“…A substance, so called gonadotropininhibiting substance (GIS), which inhibits the stimulatory effects of HCG on mouse uterine weight (Safer et al, 1961) and suppresses the ovulation induced by PMS and/or HCG in mice (Dronkert et al, 1963 ;Ota et al, 1968aOta et al, , 1968b has been found in pubertal and adult human urine. The inhibitor can be extracted from urine specimens according to the tannic acid precipitation method used for the extraction of gonadotropins excreted in the urine.…”