The Presence of
            <i>Oxalobacter formigenes</i>
            in the Microbiome of Healthy Young Adults

Barnett, C.R.; Nazzal, Lama; Goldfarb, David S.; Blaser, Martin J.

doi:10.1016/j.juro.2015.08.070

Cited by 51 publications

(43 citation statements)

References 32 publications

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“…Therefore, examining more carefully the response of different human O. formigenes strains to various environmental factors is of interest. A recent article provided interesting information regarding frequency of colonization with different O. formigenes strains (Barnett et al 2015). Their whole genome sequencing results revealed 29 of 94 subjects (31 %) were positive for O. formigenes .…”

Section: Discussionmentioning

confidence: 99%

Probiotic properties of Oxalobacter formigenes: an in vitro examination

Ellis

Dowell

et al. 2016

Arch Microbiol

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Oxalobacter formigenes (O. formigenes) is a nonpathogenic, Gram-negative, obligate anaerobic bacterium that commonly inhabits the human gut and degrades oxalate as its major energy and carbon source. Results from a case-controlled study suggested that lack of O. formigenes colonization is a risk factor for recurrent calcium oxalate stone formation. Hence, O. formigenes colonization may prove to be an efficacious method for limiting calcium oxalate stone risk. However, challenges exist in the preparation of O. formigenes as a successful probiotic due to it being an anaerobe with fastidious growth requirements. Here we examine in vitro properties expected of a successful probiotic strain. The data show that the Group 1 O. formigenes strain OxCC13 is sensitive to pH < 5.0, persists in the absence of oxalate, is aerotolerant, and survives for long periods when freeze-dried or mixed with yogurt. These findings highlight the resilience of this O. formigenes strain to some processes and conditions associated with the manufacture, storage and distribution of probiotic strains.

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Section: Discussionmentioning

confidence: 99%

Probiotic properties of Oxalobacter formigenes: an in vitro examination

Ellis

Dowell

et al. 2016

Arch Microbiol

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“…We recently described the prevalence, relative abundance and stability of Oxf in the human gut microbiome as revealed by Human Microbiome Project (HMP) data [15]. Fecal samples from 242 healthy young adults were analyzed using whole-genomic shotgun (WGS) sequencing and V13 or V35 16S rRNA sequencing.…”

Section: Oxalobacter Formigenesmentioning

confidence: 99%

The role of the microbiome in kidney stone formation

Mehta

Goldfarb

Nazzal

2016

International Journal of Surgery

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Nephrolithiasis is a complex disease of worldwide prevalence that is influenced by both genetic and environmental factors. About 75% of kidney stones are predominantly composed of calcium oxalate and urinary oxalate is considered a crucial risk factor. Microorganisms may have a role in the pathogenesis and prevention of kidney stones and the involvement of the intestinal microbiome in this renal disease has been a recent area of interest. Oxalobacter formigenes is a gram negative bacteria that degrades oxalate in the gut decreasing urinary oxalate excretion. In this review, we examine the data studying the role of Oxalobacter formigenes in kidney stone disease in humans and animals, the effect of antibiotics on its colonization, and the potential role of probiotics and whole microbial communities as therapeutic interventions.

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“…A second observed potential core bacterium was Oxalobacter, with significant presence in workers of two L. claviger colonies ( Figure S3 in Appendix S1). The function of Oxalobacter in ants remains unknown, but it has been attributed a beneficial role in humans (Barnett, Nazzal, Goldfarb, & Blaser, 2016).…”

Section: Discussionmentioning

confidence: 99%

Can social partnerships influence the microbiome? Insights from ant farmers and their trophobiont mutualists

et al. 2018

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Mutualistic interactions with microbes have played a crucial role in the evolution and ecology of animal hosts. However, it is unclear what factors are most important in influencing particular host–microbe associations. While closely related animal species may have more similar microbiota than distantly related species due to phylogenetic contingencies, social partnerships with other organisms, such as those in which one animal farms another, may also influence an organism's symbiotic microbiome. We studied a mutualistic network of Brachymyrmex and Lasius ants farming several honeydew‐producing Prociphilus aphids and Rhizoecus mealybugs to test whether the mutualistic microbiomes of these interacting insects are primarily correlated with their phylogeny or with their shared social partnerships. Our results confirm a phylogenetic signal in the microbiomes of aphid and mealybug trophobionts, with each species harbouring species‐specific endosymbiont strains of Buchnera (aphids), Tremblaya and Sodalis (mealybugs), and Serratia (both mealybugs and aphids) despite being farmed by the same ants. This is likely explained by strict vertical transmission of trophobiont endosymbionts between generations. In contrast, our results show the ants’ microbiome is possibly shaped by their social partnerships, with ants that farm the same trophobionts also sharing strains of sugar‐processing Acetobacteraceae bacteria, known from other honeydew‐feeding ants and which likely reside extracellularly in the ants’ guts. These ant–microbe associations are arguably more “open” and subject to horizontal transmission or social transmission within ant colonies. These findings suggest that the role of social partnerships in shaping a host's symbiotic microbiome can be variable and is likely dependent on how the microbes are transmitted across generations.

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The Presence of Oxalobacter formigenes in the Microbiome of Healthy Young Adults

Cited by 51 publications

References 32 publications

Probiotic properties of Oxalobacter formigenes: an in vitro examination

Probiotic properties of Oxalobacter formigenes: an in vitro examination

The role of the microbiome in kidney stone formation

Can social partnerships influence the microbiome? Insights from ant farmers and their trophobiont mutualists

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