The Presence of Mycotoxins in Feed and Their Influence on Animal Health

Gajęcki, M.; Zielonka, Łukasz

doi:10.3390/toxins12100663

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…Zearalenone is also characterized by a nonmonotonic dose-response curve (according to the principle of hormesis [43]). Therefore, the results of research studies investigating the effects of different ZEN doses on tissues [44,45], cells [46] and cell organelles [47] are difficult to compare.…”

Section: Discussionmentioning

confidence: 99%

Concentration of Zearalenone, Alpha-Zearalenol and Beta-Zearalenol in the Myocardium and the Results of Isometric Analyses of the Coronary Artery in Prepubertal Gilts

Gajęcka

Majewski

Zielonka

et al. 2021

Toxins

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The carry-over of zearalenone (ZEN) to the myocardium and its effects on coronary vascular reactivity in vivo have not been addressed in the literature to date. Therefore, the objective of this study was to verify the hypothesis that low ZEN doses (MABEL, NOAEL and LOAEL) administered per os to prepubertal gilts for 21 days affect the accumulation of ZEN, α-ZEL and β-ZEL in the myocardium and the reactivity of the porcine coronary arteries to vasoconstrictors: acetylcholine, potassium chloride and vasodilator sodium nitroprusside. The contractile response to acetylcholine in the presence of a cyclooxygenase (COX) inhibitor, indomethacin and / or an endothelial nitric oxide synthase (e-NOS) inhibitor, L-NAME was also studied. The results of this study indicate that the carry-over of ZEN and its metabolites to the myocardium is a highly individualized process that occurs even at very low mycotoxin concentrations. The concentrations of the accumulated ZEN metabolites are inversely proportional to each other due to biotransformation processes. The levels of vasoconstrictors, acetylcholine and potassium chloride, were examined in the left anterior descending branch of the porcine coronary artery after oral administration of ZEN. The LOAEL dose clearly decreased vasoconstriction in response to both potassium chloride and acetylcholine (P < 0.05 for all values) and increased vasodilation in the presence of sodium nitroprusside (P = 0.021). The NOAEL dose significantly increased vasoconstriction caused by acetylcholine (P < 0.04), whereas the MABEL dose did not cause significant changes in the vascular response. Unlike higher doses of ZEN, 5 μg/kg had no negative influence on the vascular system.

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Section: Discussionmentioning

confidence: 99%

Concentration of Zearalenone, Alpha-Zearalenol and Beta-Zearalenol in the Myocardium and the Results of Isometric Analyses of the Coronary Artery in Prepubertal Gilts

Gajęcka

Majewski

Zielonka

et al. 2021

Toxins

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“…The name "mycotoxin" is derived from the Greek word mycos (fungi) and Latin toxicum (poison). They are most often produced by fungi of the genera Aspergillus, Penicillium, Fusarium, and Alternaria [3] (Figure 1). Their synthesis depends largely on the internal parameters of fungal strains (physiological, genetic, and biochemical) [4] but also external factors such as temperature and humidity [5].…”

Section: Mycotoxinsmentioning

confidence: 99%

Mycotoxins—Prevention, Detection, Impact on Animal Health

Kępińska-Pacelik

Biel

2021

Processes

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Mycotoxins are defined as secondary metabolites of some species of mold fungi. They are present in many foods consumed by animals. Moreover, they most often contaminate products of plant and animal origin. Fungi of genera Fusarium, Aspergillus, and Penicillum are most often responsible for the production of mycotoxins. They release toxic compounds that, when properly accumulated, can affect many aspects of breeding, such as reproduction and immunity, as well as the overall liver detoxification performance of animals. Mycotoxins, which are chemical compounds, are extremely difficult to remove due to their natural resistance to mechanical, thermal, and chemical factors. Modern methods of analysis allow the detection of the presence of mycotoxins and determine the level of contamination with them, both in raw materials and in foods. Various food processes that can affect mycotoxins include cleaning, grinding, brewing, cooking, baking, frying, flaking, and extrusion. Most feeding processes have a variable effect on mycotoxins, with those that use high temperatures having the greatest influence. Unfortunately, all these processes significantly reduce mycotoxin amounts, but they do not completely eliminate them. This article presents the risks associated with the presence of mycotoxins in foods and the methods of their detection and prevention.

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“…The mechanisms underlying these changes are not yet well understood, but it is believed that they are associated with disturbances in the rumen and intestine biota, increased permeability of the gastrointestinal mucosa, and damage to the intestinal epithelium (2). The most common mycotoxins found in dairy cow feed are zearalenol (ZEN) and deoxynivalenol (DON) (11). Zearalenol is a mycotoxin produced by fungi of the Fusarium genus.…”

Section: Introductionmentioning

confidence: 99%

Assessment of selected immunological parameters in dairy cows with naturally occurring mycotoxicosis before and after the application of a mycotoxin deactivator

Brodzki¹,

Marczuk²,

Lisiecka

et al. 2023

Journal of Veterinary Research

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Introduction Mycotoxins in dairy cows can cause many non-specific symptoms often resulting from immune system overreaction. The study assessed the concentration of selected cytokines and acute phase proteins (APP) in cows with natural mycotoxicosis before and after using a mycotoxin neutraliser. The cytokines were tumour necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interleukin 10 (IL-10), and the APP were serum amyloid A (SAA) and haptoglobin (Hp). Material and Methods The research was carried out on an experimental group (Exp) of 10 herdmate Holstein-Friesian cows with mycotoxicosis. The control group (Con) was 10 healthy cows of the same breed from a different herd. Cows in the Exp group were administered the mycotoxin deactivator Mycofix for three months. Blood was drawn from Exp cows once before administering Mycofix and a second time after three months of its use. Blood was also drawn from Con cows at the same times. Serum levels of TNF-α, IL-6, IL-10, SAA and Hp were assessed using ELISA. Results The concentrations of all cytokines and Hp in Exp cows were higher before treatment (P < 0.001) than those in Con cows. After three months of administering Mycofix, the concentrations of TNF-α and IL-6 were significantly lower than their pre-treatment levels (P < 0.001). The concentrations of IL-6, IL-10, and Hp were still significantly higher than those in the Con group (P < 0.001). In cows with mycotoxicosis, simultaneous stimulation of antagonistic processes was noted: a pro-inflammatory process in the upregulation of TNF-α and IL-6, and an anti-inflammatory one in the upregulation of IL-10. Conclusion Despite the absorbent’s use and the resolution of clinical symptoms in Exp cows, high levels of IL-10 and Hp and IL-6 were maintained. Assessment of the level of cytokines and APP appears to be a useful and precise tool for the evaluation and application of the appropriate dose of the mycotoxin absorbent or the evaluation of its effectiveness.

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The Presence of Mycotoxins in Feed and Their Influence on Animal Health

Abstract: Mycotoxins are secondary metabolites of fungi [...]

Cited by 9 publications

References 12 publications

Concentration of Zearalenone, Alpha-Zearalenol and Beta-Zearalenol in the Myocardium and the Results of Isometric Analyses of the Coronary Artery in Prepubertal Gilts

Concentration of Zearalenone, Alpha-Zearalenol and Beta-Zearalenol in the Myocardium and the Results of Isometric Analyses of the Coronary Artery in Prepubertal Gilts

Mycotoxins—Prevention, Detection, Impact on Animal Health

Assessment of selected immunological parameters in dairy cows with naturally occurring mycotoxicosis before and after the application of a mycotoxin deactivator

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