“…In summary, we here demonstrate that pwMS on anti-CD20 treatment develop an immunological SARS-CoV-2 T cell memory response that displays similar characteristics as pwMS on other DMTs and HC, while the humoral response is affected by treatment including a tendency of decreasing antibody levels but with a remaining strong T cell response (Ibarrondo et al, 2020;Maillart et al, 2020;Peng et al, 2020;Wallach and Picone, 2021;Weiskopf et al, 2020). Furthermore, the post-vaccination data are in accordance with ll OPEN ACCESS iScience Article previous studies reporting an attenuated antibody response to SARS-CoV-2 mRNA and also other types of vaccines for patients on anti-CD20 treatment (Achiron et al, 2021;Baker et al, 2020;Bar-Or et al, 2020;Bigaut et al, 2021;Gallo et al, 2021;Guerrieri et al, 2021) and also demonstrate that absence of B cells in blood is a poor predictor of capacity to develop a humoral response.…”