The present and future of nanotechnology in human health care

Sahoo, Sanjeeb K.; Parveen, Suphiya; Panda, Jiban Jyoti

doi:10.1016/j.nano.2006.11.008

Cited by 738 publications

(276 citation statements)

References 116 publications

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“…Nanotechnology is a discipline that has expanded rapidly into all areas of science and it offers valuable options for solving medical and scientific problems and questions (Abou Neel et al, 2015). A dental field of nanotechnology called nanodentistry is very promising and have demonstrated various treatment opportunities in dentistry in areas such as dental re-naturalization, local anesthesia, teeth hypersensitivity cure (Sahoo et al, 2007), periodontal regeneration (Walmsley et al, 2015), controlled drug delivery (Abou Neel et al, 2015;Jain et al, 2008) and overall oral health maintenance (Ozak and Ozkan, 2013), among others. This highly promising field may ensure the attainment of near perfect oral health by way of using nanomaterials, nanorobotics, biotechnology, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Bhavikatti et al, 2014). Nanodentistry will make it possible to induce local anesthesia efficiently in the years to come, through the aid of nanorobots (Sahoo et al, 2007). Colloidal carriers containing active analgesic dental nanorobotic particles in millions and/or antibacterial agents could be directly installed into the patient's gingivae (Sahoo et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Nanodentistry will make it possible to induce local anesthesia efficiently in the years to come, through the aid of nanorobots (Sahoo et al, 2007). Colloidal carriers containing active analgesic dental nanorobotic particles in millions and/or antibacterial agents could be directly installed into the patient's gingivae (Sahoo et al, 2007). These nanorobots would be able to make surface contact with the mucosa/crown and eventually get to dentin by moving painlessly through the gingival sulcus to the target site (Sahoo et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Colloidal carriers containing active analgesic dental nanorobotic particles in millions and/or antibacterial agents could be directly installed into the patient's gingivae (Sahoo et al, 2007). These nanorobots would be able to make surface contact with the mucosa/crown and eventually get to dentin by moving painlessly through the gingival sulcus to the target site (Sahoo et al, 2007). The future roles of nanotechnology approaches seem to influence almost every aspect of human life, and with its advancement, researchers are acquiring abilities to understand and manipulate materials at the nanoscale (Gambhir et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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“…17 --20 The targeted gene delivery using bioconjugates is exploring to increase the efficiency of drug delivery to specific tissues as well as to decrease the minimum effective dose of the drug as well as its side effects. 21 Strategies to develop tumor-cell-specific bioconjugates are multimodal, but all attempts to selectively deliver therapeutics to cells use nano-and submicron-scale carriers such as dendrimers, liposomes, polymers, emulsions or viruses including active and/or passive targeting moieties. 22 Folic acid (FA) has been shown to be one of the most promising ligands for targeting a range of human carcinomas, including breast, ovary, endometrium, kidney, lung, head and neck, brain and myeloid cancers, which are known to express folate receptors (FR).…”

Section: Introductionmentioning

confidence: 99%

Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells

et al. 2012

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We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with a-cyclodextrin (a-CyD) having an average degree of substitution of 2.4 of a-CyD (a-CDE) provided remarkable aspects as novel carriers for DNA and small-interfering RNA. To develop novel a-CDE derivatives with tumor cell specificity, we prepared folate-appended a-CDEs (Fol-a-CDEs) and folate-polyethylene glycol (PEG)-appended a-CDEs (Fol-PaCs) with the various degrees of substitution of folate (DSF), and evaluated in vitro and in vivo gene transfer activity, cytotoxicity, cellular association and physicochemical properties. In vitro gene transfer activity of Fol-a-CDEs (G3, DSF 2, 5 or 7) was lower than that of a-CDE (G3) in KB cells, folate receptor (FR)-overexpressing cancer cells. Of the three Fol-PaCs (G3, DSF 2, 5 or 7), Fol-PaC (G3, DSF 5) had the highest gene transfer activity in KB cells. The activity of Fol-PaC (G3, DSF 5) was significantly higher than that of a-CDE (G3) in KB cells, but not in A549 cells, FR-negative cells. Negligible cytotoxicity of the plasmid DNA (pDNA) complex with Fol-PaC (G3, DSF 5) was observed in KB cells or A549 cells up to a charge ratio of 100/1 (carrier/pDNA). The cellular association of the pDNA complex with Fol-PaC (G3, DSF 5) could be mediated by FR on KB cells, resulting in its efficient cellular uptake. Fol-PaC (G3, DSF 5) had a higher binding affinity with folate-binding protein than a-CDE (G3), although the physicochemical properties of pDNA complex with Fol-PaC (G3, DSF 5) were almost comparable to that with a-CDE (G3), although the onset charge ratio and the compaction ability of Fol-PaC (G3, DSF 5) were slightly different. Fol-PaC (G3, DSF 5) tended to show a higher gene transfer activity than a-CDE (G3) 12 h after intratumoral administration in mice. These results suggest that Fol-PaC (G3, DSF 5), not Fol-a-CDEs, could be potentially used as a FR-overexpressing cancer cell-selective DNA carrier.

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Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting their Target

Rossin

2011

Nanoplatform‐Based Molecular Imaging

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Nanomedicine is a rapidly evolving field. Every year, new and more sophisticated nanoplatforms (NPs) designed to deliver drugs to specific targets or for molecular imaging of disease states make their appearance on the scientific scene. The assessment of the in vivo distribution of these NPs is the first step in order to fully understand their potential as candidate nanomedicines and to predict and prevent toxic side effects. To this aim, the incorporation of a radionuclide in the NP is of great advantage, as radiometric assays are rapid and quantitative. Furthermore, noninvasive nuclear imaging techniques are highly sensitive, achieve high tissue penetration and good spatial resolution, and can accelerate the translation of new NPs into the clinic. This chapter gives an overview of the strategies to label NPs with a variety of radionuclides (radiometals and radiohalogens), focusing on some of the hurdles that scientists must overcome (or take into consideration) when administering these radioconjugates in vivo. Furthermore, the latest achievements in molecular imaging of angiogenesis with radiolabeled NPs are reviewed.The most recent publications on nanoplatforms labeled with ␥ -and ␤ + -emitting radionuclides for SPECT and PET imaging are reviewed. Different strategies to label nanoplatforms are described, particularly those involving radiometals ( 64 Cu, 111 In, 67/68 Ga, 86 Y, 99m Tc, and 186/188 Re) and radiohalogens ( 123/124/125/131 I, 76 B, and 18 F). Some of the problems occurring when evaluating radiolabeled nanoplatforms in vivo are also covered. Finally, the use of radiolabeled nanoplatforms for angiogenesis imaging with PET and SPECT is discussed.

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The present and future of nanotechnology in human health care

Cited by 738 publications

References 116 publications

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells

Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting their Target

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