The prevalence and clinical characteristics of coinfection of SENV-H among Taiwanese chronic hepatitis C patients with combination therapy of high-dose interferon-alfa and ribavirin

Dai, Chia‐Yen; Chuang, Wan‐Long; Chang, Wen‐Yu; Chen, Shinn‐Cherng; Lee, Li‐Po; Hou, Nai‐Jen; Hsieh, Ming‐Yuh; Wang, Liang‐Yen; Yu, Ming‐Lung

doi:10.1016/j.antiviral.2004.05.003

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…However, SENV-H infection was only found in mothers who had HCV genotype 1b. Association between HCV genotype 1b and SENV genotype H has also been reported by Dai et al [19] in Taiwanese chronic hepatitis C patients. It is not possible, at present, to speculate on the cause of that association.…”

Section: Discussionsupporting

confidence: 71%

SEN virus co‐infection among HCV‐RNA‐positive mothers, risk of transmission to the offspring and outcome of child infection during a 1‐year follow‐up

Moriondo

Resti

Betti

et al. 2006

Journal of Viral Hepatitis

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SEN is a newly discovered blood-transmissible virus. Among its variants, SENV-D and -H are most often associated with non-A, -E hepatitis. Very little is known about the risk of vertical transmission of the virus. By using polymerase chain reaction with specific primers for SENV-D and -H, we investigated the prevalence of SENV-H and -D infection, the transmission rate of SENV infection and clinical features of SENV-infected children in 89 hepatitis C virus (HCV)-positive human immunodeficiency virus type 1-negative mothers. SENV infection was found in 36 (40%) mothers, and SENV-D was more frequent than SENV-H infection (34/36, 94%vs 5/36, 14%, P < 0.01). No difference in SENV infection rates was found between injection drug user (IDU) mothers (17/51, 33%) and mothers with no risk for bloodborne infection (19/38, 50%, P = ns). SENV-H infection was found only in IDU mothers and mothers with HCV genotype1b. Both SENV-D and -H can be transmitted to the offspring with an overall rate of 47%. Vertical transmission of HCV does not facilitate SENV infection of the offspring. Among 17 SENV-infected children, none was co-infected with HCV. Maternal HCV genotype or viral load does not interfere with mother-to-infant transmission of SENV. Persistence of SENV infection was demonstrated in 100% of infected children after 1-year follow-up, but none had clinical evidence of liver disease.

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Section: Discussionsupporting

confidence: 71%

SEN virus co‐infection among HCV‐RNA‐positive mothers, risk of transmission to the offspring and outcome of child infection during a 1‐year follow‐up

Moriondo

Resti

Betti

et al. 2006

Journal of Viral Hepatitis

View full text Add to dashboard Cite

show abstract

“…For anti-HCV-positive patients, the low platelet count also predicts the presence of HCV viremia with a sensitivity of 88.8%. Since the presence of HCV RNA plays an essential role in disease progression, there is the necessity for the effective interferon-based therapies developed to treat HCV infection [35][36][37][38][39] and low platelet count, not only those associated with positive anti-HCV but also those with HCV viremia; this should help clinicians identify patients with active HCV infection for further intervention. Abnormal ALT levels were associated with positive anti-HCV in the present study and were correlated with HCV viremia through the finding that HCV RNA is more commonly detected in subjects with abnormal ALT levels than in subjects with normal levels, as in the previous study [10].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus viremia and low platelet count: A study in a hepatitis B & C endemic area in Taiwan

Dai

Huang

et al. 2010

Journal of Hepatology

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Polymorphisms in the interferon-γ gene at position +874 in patients with chronic hepatitis C treated with high-dose interferon-α and ribavirin

et al. 2005

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The prevalence and clinical characteristics of coinfection of SENV-H among Taiwanese chronic hepatitis C patients with combination therapy of high-dose interferon-alfa and ribavirin

Cited by 5 publications

References 32 publications

SEN virus co‐infection among HCV‐RNA‐positive mothers, risk of transmission to the offspring and outcome of child infection during a 1‐year follow‐up

SEN virus co‐infection among HCV‐RNA‐positive mothers, risk of transmission to the offspring and outcome of child infection during a 1‐year follow‐up

Hepatitis C virus viremia and low platelet count: A study in a hepatitis B & C endemic area in Taiwan

Polymorphisms in the interferon-γ gene at position +874 in patients with chronic hepatitis C treated with high-dose interferon-α and ribavirin

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