The Prevalence And Outcomes Of Depression In Older HIV-Positive Adults In Northern Tanzania: A Longitudinal Study

Dua, Damneek; Stubbs, O. Oztug D.; Urasa, Sarah; Rogathi, Jane; Duinmaijer, Ashanti; Howlett, William P.; Dekker, Marieke; Kisoli, Aloyce; Mukaetova‐Ladinska, Elizabeta B.; Gray, William K.; Lewis, Thomas H.; Walker, Richard; Dotchin, Catherine; Lwezuala, Bingileki; Makupa, Philip C.; Paddick, Stella-Maria

doi:10.21203/rs.3.rs-1333017/v1

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…Although, in this article, we have not delved into the causes of depression in elderly PLWH, several studies have associated it with HIV-associated neurocognitive disorders, 25–27 apart from poor neurological and functional outcomes and negative life events 28 . HIV-associated neurocognitive disorders and depressive symptoms that occur frequently in elderly PLWH can in turn serve as stronger factors for functional impairment among these patients 14 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Depression in Elderly People Living With HIV: A Systematic Review and Meta-analysis

Ahmed,

Saha,

Almusalami

et al. 2023

Infect Microb Dis

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We conducted a systematic review and meta-analysis to determine the prevalence of depression among elderly people living with HIV. We searched electronic databases and included 12 observational studies that reported on depression among people who were 50 years of age or older and had HIV. The studies were mostly hospital-based and from Western and African countries. They included a total of 5868 older people with HIV, of whom 1667 had depression. Pooled prevalence of depression was 28% with heterogeneity of 95.2%. Prevalence ranged from 14.5% in the Netherlands to 42.4% in South Africa. Although there was asymmetry in the funnel plot, the Egger’s test showed no significant publication bias. Our meta-analysis found a high burden of depression among older people with HIV. Comprehensive health services addressing psychosocial needs and interventions to prevent and treat depression are needed, especially in community settings. Healthcare providers and policymakers should address the prevalence of depression in such communities.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Depression in Elderly People Living With HIV: A Systematic Review and Meta-analysis

Ahmed,

Saha,

Almusalami

et al. 2023

Infect Microb Dis

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“…A recent Malaysian study noted higher risk of cognitive decline in individuals with psychosocial stressors [31]. Similarly, in a 2-year Tanzanian study of older people with HIV baseline, depression was associated with increased risk of functional and neurological impairment [32]. The potential aetiological overlap with depression and level of comorbidity represents an additional current knowledge gap.…”

Section: Phenotype Of Cognitive Impairment In Hivmentioning

confidence: 99%

Recent advances in HIV-associated neurocognitive disorders: a focus on older adults and sub-Saharan Africa

Paddick,

Mukaetova-Ladinska

2023

Current Opinion in Psychiatry

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Purpose of review We reviewed recent literature on prevalence and interventional approaches for cognitive impairment in the context of HIV infection alongside current controversies and challenges around its nomenclature, screening, and diagnosis. Recent findings Prevalence estimates for HIV-associated neurocognitive disorder (HAND) indicate that HAND remains highly prevalent despite combination antiretroviral treatment (cART) widely used. The available data are heterogeneous, particularly in sub-Saharan Africa (SSA) where recent reviews indicate substantial heterogeneity, wide prevalence estimates and lack of data from the majority SSA countries, despite them currently experiencing the greatest burden worldwide of both HIV and HAND. Several alternative approaches to diagnosis and classification of cognitive impairment in HIV have been published, taking into account changing clinical phenotypes. Summary Cognitive impairment remains a significant challenge in the care of people living with HIV despite advances in treatment. Ongoing controversies exist around nomenclature and classification, screening measures, and the phenotype and aetiology of observed impairments. Two current areas of research priority and focus include understanding current phenotypes of individuals living and ageing with treated HIV and differing levels of risk for HAND in these phenotypes, alongside the effects of commonly occurring comorbidities. The current evidence base for interventional approaches is limited, but growing. The most promising avenues appear to be multidisciplinary. These are currently focussed on high income settings rather than SSA where the majority of people living with HIV, and affected by cognitive impairment in the context of HIV, currently reside.

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The Prevalence And Outcomes Of Depression In Older HIV-Positive Adults In Northern Tanzania: A Longitudinal Study

Cited by 2 publications

References 43 publications

Prevalence of Depression in Elderly People Living With HIV: A Systematic Review and Meta-analysis

Prevalence of Depression in Elderly People Living With HIV: A Systematic Review and Meta-analysis

Recent advances in HIV-associated neurocognitive disorders: a focus on older adults and sub-Saharan Africa

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