The Prevalence and Risk Factors of Undiagnosed Depression and Anxiety Disorders Among Patients With Inflammatory Bowel Disease

Abstract

Background Inflammatory bowel disease (IBD) is associated with a high prevalence of comorbid depressive and anxiety disorders. A significant proportion of IBD patients with comorbid psychiatric disorders remain undiagnosed and untreated, but factors associated with diagnosis are unknown. We evaluated the prevalence of undiagnosed depression and anxiety in an IBD cohort, along with the associated demographic and clinical characteristics. Methods We obtained data from the enrollment visit of a cohort study of psychiatric comorbidity in immune-mediated diseases including IBD. Each participant underwent a Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID) to identify participants who met lifetime criteria for a diagnosis of depression or anxiety. Those with a SCID-based diagnosis were classified as diagnosed or undiagnosed based on participant report of a physician diagnosis. Results Of 242 eligible participants, 97 (40.1%) met SCID criteria for depression, and 74 (30.6%) met criteria for anxiety. One-third of participants with depression and two-thirds with anxiety were undiagnosed. Males were more likely to have an undiagnosed depressive disorder (odds ratio [OR], 3.36; 95% confidence interval [CI], 1.28–8.85). Nonwhite participants were less likely to have an undiagnosed anxiety disorder (OR, 0.17; 95% CI, 0.042–0.72). Conclusion Our findings highlight the importance of screening for depression and anxiety in patients with IBD, with particular attention to those of male sex and with a lower education level.

COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey

“…Furthermore, many patients seeking medical consultation for gastrointestinal problems show an associated affective disorder [27]. Patients with IBD are 3-5 times more likely to develop anxiety disorders [28][29][30].…”

Iron deficiency, depression, and fatigue in inflammatory bowel diseases

“…Despite the presence of specific guidelines on ID in IBD [4, 53,54], health care providers demonstrate a low level of awareness and a high variation in clinical management [55]. Depression and anxiety are also underdiagnosed [56]. Both the implementation and correct interpretation of routine FER testing, as well as the clinical recognition of fatigue and depression in patients with IBD, should trigger more frequent iron replacement therapy in this high-risk cohort.…”

Depresszív tüneteket és öngyilkossági gondolatokat befolyásoló tényezők gyulladásos bélbetegségben szenvedők körében

“…A folyamatok kétirányúsága miatt a depresszió kezelése és/vagy a betegség aktivitásának visszaszorítása hatással lehet a betegek szubjektív életminőségére is [6,35]. A nem vagy aluldiagnosztizált komorbid pszichiátriai zavarok, mint a depresszió, hosszú távon jelentős terhet jelentenek a gyulladásos bélbetegekre és az őket kezelő egészségügyi ellátórendszerre is [36]. Összefoglalásként elmondható, hogy a gyulladásos bélbetegek esetében a pszichés komorbiditás, ezen belül a depresszió, az öngyilkossági gondolatok szűrése a saját vizsgálatunkban és a szakirodalomban talált magas előfordulás miatt a betegek hosszú távú kezelése és életminőségük szempontjából is kiemelt jelentőségű.…”