The prevalence and severity of potential drug-drug interactions among adult polypharmacy patients at outpatient clinics in Jordan

Nusair, Mohammad B.; Al‐Azzam, Sayer; Arabyat, Rasha M.; Amawi, Haneen; Alzoubi, Karem H.; Rabah, Asma A.

doi:10.1016/j.jsps.2019.11.009

Cited by 45 publications

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“…These practices would increase the risk of drug‐related problems (eg, drug interactions and side effects), masking symptoms of underlying conditions and the development of bacterial resistance 9 . Moreover, the majority of pharmacists in Jordan do not check for potential drug‐drug interactions when they dispense medications 39 . Therefore, pharmacists' practices of antibiotic dispensing without a prescription will add to the high prevalence of drug‐drug interactions and unnecessary medication costs in Jordan 39,40 …”

Section: Discussionmentioning

confidence: 99%

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The prevalence and patterns of self‐medication with antibiotics in Jordan: A community‐based study

et al. 2020

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Background Self‐medication with antibiotics is one of the leading causes of antibiotic resistance and drug therapy problems, making antibiotic self‐medication practices a global concern. Despite global efforts to limit these practices, self‐medication with antibiotics remains prevalent in developing countries. This study aimed to investigate the prevalence and patterns of self‐medication with antibiotics in Jordan and to compare the findings of self‐medication practices with antibiotics with results from 2006. Method A cross‐sectional community‐based study used a convenient sampling technique and recruited a large sample from all over Jordan. Between February and April 2019 trained 5th‐year pharmacy students recruited participants (eg, door to door) who had taken antibiotics in the preceding month. The questionnaire consisted of 14 questions that aimed to describe the patterns of self‐medication with antibiotics. Results A total of 1928 participants took part in this study. Of the 1928 respondents, 40.4% reported having used an antibiotic without a prescription in the previous month. Participants who had self‐medicated with antibiotics had primarily used them for sore throat and influenza. Self‐medicated participants had obtained antibiotics primarily from pharmacies (57.2%) and relied primarily on pharmacists (34.8%) and their own previous experience (35.2%) for information on the proper use of antibiotics. The rate of self‐medication with antibiotics in Jordan in 2019 (40.4%) had not changed significantly since 2006 (39.5%, P = .295). However, self‐medication practices (eg, source of antibiotic supply and information) have changed over the year. Conclusion The findings of this study revealed that the prevalence of self‐medication with antibiotics in Jordan remains high. This is a significant concern that requires a quick response from the government authorities to develop a collaborative approach to stop the dispensing of antibiotics without a prescription.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, the majority of pharmacists in Jordan do not check for potential drug‐drug interactions when they dispense medications 39 . Therefore, pharmacists' practices of antibiotic dispensing without a prescription will add to the high prevalence of drug‐drug interactions and unnecessary medication costs in Jordan 39,40 …”

Section: Discussionmentioning

confidence: 99%

The prevalence and patterns of self‐medication with antibiotics in Jordan: A community‐based study

et al. 2020

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“…DDIs are highly prevalent not only in outpatients but also in hospitalized patients especially in ICU [ 6 , 7 ], oncology [ 8 – 10 ] and hematology [ 11 , 12 ]. The prevalence of pDDIs varies from 16% to 96% in different studies [ 13 – 16 ]. Given the lack of investigation on the epidemiology of DDIs in the outpatients of Jinshan Hospital, Fudan University, the present study aimed to gain insight into the real-world prevalence of pDDIs in outpatient prescriptions and classify the severity of the interactions.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation

et al. 2020

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Background Potential drug-drug interactions are important factors resulting in adverse drug reactions or therapeutic failure. Therefore, potential drug-drug interactions need to be identified to prevent the related risk and improve drug safety. Objective This study was designed to determine the prevalence of potential drug-drug interactions and investigate the association of potential drug-drug interactions with characteristics in outpatient prescriptions. Setting A large-scale general university hospital in Jinshan District of Shanghai, China. Method The retrospective study was conducted on data obtained from prescriptions containing two or more drugs, written for outpatients older than 18 years. They were screened for potential drug-drug interactions using Lexi-Interact in UpToDate, Stockley's Drug Interactions and Medicine Specification in the order of priority. Main outcome measure Drug-drug interactions with C, D, X risk rating and clinical parameters recorded at the prescriptions. Results 16,120 prescriptions were screened for the presence of potential drug-drug interactions and 4882 (30.29%) prescriptions containing 6667 potential drug-drug interactions were identified. Among 6667 potential drug-drug interactions, 90.81% (6054/6667), 8.49% (566/6667), 0.70% (47/6667) potential drug-drug interactions belonged to the risk category of C, D and X, respectively. Male, old age and polypharmacy increased the likelihood of potential drug-drug interactions. The most frequently prescribed drugs responsible for potential drug-drug interactions included pioglitazone, dihydrocodeine, thalidomide, sotalol, amiodarone and amlodipine. The predominant potential adverse outcome of potential drug-drug interactions was the increased central nervous system suppression function with the mechanism of reinforced pharmacological effects. Conclusion This study showed that potentially significant drug-drug interactions in outpatients were prevalent in real-world practice. Considering the risk of potential clinical consequences related to potential drug-drug interactions, it is necessary to implement the computerized surveillance and warning systems with drug-drug interactions databases as well as develop the clinical guidelines regarding the widespread potential drug-drug interactions.

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“…DDI is defined as the alterations in the pharmacologic effect of a drug resulting from another drug used concomitantly for the same or different disorders. The prevalence of DDIs varies between 16% and 96% in several studies conducted on different patient groups and settings [4][5][6][7][8][9][10][11] . DDIs are significant risk factors for adverse drug reactions and hospitalizations.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

Özdamar

2021

Cukurova Medical Journal

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ÖzPurpose: The aim of the present study is to determine the frequency and severity of possible drug-drug interactions (DDIs) in the prescriptions of patients who admitted to the orthopedics and traumatology outpatient clinics. Materials and Methods: This cross-sectional, retrospective study analyzed the prescription data of patients that admitted to orthopedics and traumatology outpatient clinics of a tertiary care hospital from January 1, 2020 to February 15, 2020. The severity of DDIs was interpreted using the Lexi-comp® drug interaction database. Relationship between the presence of DDIs and the number of prescribed drugs were evaluated. Results: Out of 753 patient data evaluated, a total of 2248 drugs were prescribed. Among 669 polypharmacy patients, 293 (43.8%) patients had one or more potential DDIs. A total of 437 DDIs were detected of which 300 (68.6%) were D, 82 (18.8%) were X, 49 (11.2%) were C and 6 (1.4%) were B risk category interactions. The most common DDIs were between systemic Diclofenac and topical Diclofenac, (14.4%) The presence of potential DDIs was significantly associated with adult age and female gender. Conclusion:Although, the severity of the potential DDIs in orthopedics and traumatology outpatient clinics were generally moderate and manageable, it is crutial for physicians to be aware of the interactions between the most frequently prescribed drugs in orthopedics and traumatology outpatient clinics, monitor patients for the safe use of drugs. Amaç: Bu çalışmanın amacı, ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçetelerinde olası ilaçilaç etkileşimlerinin sıklığını ve şiddetini belirlemektir. Gereç ve Yöntem: Bu kesitsel retrospektif çalışma, 1 Ocak 2020-15 Şubat 2020 tarihleri arasında üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçete verilerini analiz etti. İlaç-ilaç etkileşimlerinin şiddeti, Lexi-comp® ilaç etkileşimi veri tabanı kullanılarak yorumlandı. İlaç-ilaç etkileşimi varlığı ile reçetelenmiş ilaç sayısı arasındaki ilişki değerlendirildi. Bulgular: Değerlendirilen 753 hasta verisinde toplam 2248 ilaç reçete edildi. 669 polifarmasi hastasından, 293 (%43.8) hastanın bir veya daha fazla potansiyel ilaç-ilaç etkileşimi vardı. 300'ü (%68.6) D, 82'si (%18.8) X, 49'u (%11.2) C ve 6'sı (%1.4) B risk kategorisi etkileşimleri olmak üzere toplam 437 ilaç-ilaç etkileşimi tespit edildi. En sık ilaç-ilaç etkileşimleri sistemik diklofenak ve topical diklofenak arasındaydı (%14.4). Olası ilaç-ilaç etkileşimlerinin varlığı erişkin yaş ve kadın cinsiyet ile anlamlı olarak ilişkiliydi. Sonuç: Ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin şiddeti genel olarak orta düzeyde ve yönetilebilir olsa da, ortopedi ve travmatoloji polikliniklerinde en sık reçete edilen ilaçlar arasındaki etkileşimlerden haberdar olmak ve ilaçların güvenli kullanımı için hastaları izlemek hekimler açısından önem taşımaktadır.

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The prevalence and severity of potential drug-drug interactions among adult polypharmacy patients at outpatient clinics in Jordan

Cited by 45 publications

References 38 publications

The prevalence and patterns of self‐medication with antibiotics in Jordan: A community‐based study

The prevalence and patterns of self‐medication with antibiotics in Jordan: A community‐based study

Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation

Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

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