The prevalence of 30 ICD-10 autoimmune diseases in Denmark

Eaton, William W.; Pedersen, Marianne Bruus; Atladóttir, Hjördís Ósk; Gregory, Patricia; Rose, Noel R.; Mortensen, Preben Bo

doi:10.1007/s12026-009-8153-2

Cited by 71 publications

(68 citation statements)

References 2 publications

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“…This prevalence is higher than what has been reported in hospital-based study, and it is similar only to prevalence values obtained in the United Kingdom [1], [9], [12].…”

Section: Discussionsupporting

confidence: 82%

Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

et al. 2012

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BackgroundThe limited availability of prevalence data based on a representative sample of the general population, and the limited number of diseases considered in studies about co-morbidity are the critical factors in study of autoimmune diseases. This paper describes the prevalence of 12 autoimmune diseases in a representative sample of the general population in the South of Sardinia, Italy, and tests the hypothesis of an overall association among these diseases.MethodsData were obtained from 21 GPs. The sample included 25,885 people. Prevalence data were expressed with 95% Poisson C.I. The hypothesis of an overall association between autoimmune diseases was tested by evaluating the co-occurrence within individuals.ResultsPrevalence per 100,000 are: 552 rheumatoid arthritis, 124 ulcerative colitis, 15 Crohn's disease, 464 type 1 diabetes, 81 systemic lupus erythematosus, 124 celiac disease, 35 myasthenia gravis, 939 psoriasis/psoriatic arthritis, 35 systemic sclerosis, 224 multiple sclerosis, 31 Sjogren's syndrome, and 2,619 autoimmune thyroiditis . An overall association between autoimmune disorders was highlighted.ConclusionsThe comparisons with prevalence reported in current literature do not show outlier values, except possibly for a few diseases like celiac disease and myasthenia gravis. People already affected by a first autoimmune disease have a higher probability of being affected by a second autoimmune disorder. In the present study, the sample size, together with the low overall prevalence of autoimmune diseases in the population, did not allow us to examine which diseases are most frequently associated with other autoimmune diseases. However, this paper makes available an adequate control population for future clinical studies aimed at exploring the co-morbidity of specific pairs of autoimmune diseases.

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“…This prevalence is higher than what has been reported in hospital-based study, and it is similar only to prevalence values obtained in the United Kingdom [1], [9], [12].…”

Section: Discussionsupporting

confidence: 82%

Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

et al. 2012

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“…The perception of an infectious cause of schizophrenia emerged from anecdotal evidence over 150 years ago. Modern epidemiological evidence from national registries describes a cohort of individuals with genetic vulnerabilities for immune disorders and psychosis (Eaton et al, 2010;Severance et al, 2014aSeverance et al, , 2014b. Severe infections and autoimmune disorders over a lifetime appeared to confer additive risk for schizophrenia and schizophrenia spectrum disorders (Benros et al, 2013b;Meyer, 2011).…”

Section: Systemic Infections and Neurodevelopmental Mechanismsmentioning

confidence: 99%

Clinical studies of neuroinflammatory mechanisms in schizophrenia

Watkins

Andrews

2016

Schizophrenia Research

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“…These diseases encompass a wide range of associated pathology, affecting many different tissue and organ sites. At present, 80–100 autoimmune diseases have been described, although detailed epidemiology is not available for all of them [1, 2]. The etiology of autoimmune diseases is not completely understood but is thought to involve gene-environmental interactions [3].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases

et al. 2016

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The measurement of autoantibodies in the clinical care of autoimmune patients allows for diagnosis, monitoring, and even disease prediction. Despite their clinical utility, the functional significance of autoantibody target proteins in many autoimmune diseases remains unclear. Here we present a comprehensive review of 52 autoantigens commonly employed for the serological diagnosis of 24 autoimmune diseases. We discuss their function, whether they have extracellular-exposed epitopes, and whether antibodies to these proteins are known to be pathogenic. Transcriptomics (RNA-Seq) datasets were mined to display messenger RNA (mRNA) expression of the autoantigens across 32 tissues and organs. This analysis revealed that autoantigens cluster into one of three groups: expression in the tissue most strongly affected in the disease (Group I), ubiquitous expression with enrichment in immune tissues (Group II), or expression in other tissues not typically associated with the clinical presentation (Group III). Clustering demonstrated that the autoantigens within Group I were often proteins containing extracellular epitopes, many of which are targets of pathogenic autoantibodies. Group II autoantigens were targets for several rheumatological diseases, including Sjögren syndrome, systemic lupus erythematosus, myositis, and systemic sclerosis, and were ubiquitously expressed with enrichment in immune-rich tissues. This raises the possibility that immune cells in Group II disorders may be the source of autoimmunization and/or targets of immune cell responses. Since tissues showing enriched autoantigen gene expression may contribute to the development of autoantibodies and subsequent autoimmunity, the emergent patterns arising from the autoantigen transcriptomic profiles may provide a new heuristic framework to deconvolute these complex disorders.

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The prevalence of 30 ICD-10 autoimmune diseases in Denmark

Cited by 71 publications

References 2 publications

Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

Clinical studies of neuroinflammatory mechanisms in schizophrenia

Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases

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