The Prevalence of Amnestic and Non-Amnestic Mild Cognitive Impairment and Its Association with Different Lifestyle Factors in a South Italian Elderly Population

Caffò, Alessandro O.; Spano, Giuseppina; Tinella, Luigi; Lopez, Antonella; Ricciardi, Elisabetta; Stasolla, Fabrizio; Bosco, Andrea

doi:10.3390/ijerph19053097

Cited by 14 publications

(8 citation statements)

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“…Thus, our population can be regarded as representative of a typical HD population. In addition, we observed a higher prevalence of MCI and malnutrition compared to an age-matched population without CKD [ 48 , 49 ]. This identifies the role of CKD in increasing the risk of nutritional and cognitive alterations [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin

et al. 2023

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Cognitive impairment and malnutrition are prevalent in patients on hemodialysis (HD), and they negatively affect the outcomes of HD patients. Evidence suggests that cognitive impairment and malnutrition may be associated, but clinical studies to assess this association in HD patients are lacking. The aim of this study was to evaluate the association between cognitive impairment evaluated by the Montreal Cognitive Assessment (MoCA) score and nutritional status evaluated by the malnutrition inflammation score (MIS) in HD patients. We enrolled 84 HD patients (44 males and 40 females; age: 75.8 years (63.5–82.7); HD vintage: 46.0 months (22.1–66.9)). The MISs identified 34 patients (40%) as malnourished; the MoCa scores identified 67 patients (80%) with mild cognitive impairment (MCI). Malnourished patients had a higher prevalence of MCI compared to well-nourished patients (85% vs. 70%; p = 0.014). MoCa score and MIS were negatively correlated (rho:−0.317; p < 0.01). Our data showed a high prevalence of MCI and malnutrition in HD patients. Low MoCA scores characterized patients with high MISs, and malnutrition was a risk factor for MCI. In conclusion, it is plausible that MCI and malnutrition are linked by common sociodemographic, clinical, and biochemical risk factors rather than by a pathophysiological mechanism.

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Section: Discussionmentioning

confidence: 99%

Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin

et al. 2023

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“…To our knowledge, no studies have focused on the association between lifestyle and genetic risk ( APOE and MTHFR ) in the development of MCI, and most have focused on single lifestyle factors or the APOE gene instead of combined factors . A cross-sectional study of Chinese adults aged 80 years or older showed that healthy lifestyle was associated with better cognitive function in older adults, regardless of APOE genotype .…”

Section: Discussionmentioning

confidence: 99%

“…Risk of MCI with lifestyle factors and genetic risks was further analyzed in sensitivity analyses using the combinations of unweighted lifestyle categories and weighted genetic risks, weighted lifestyle categories and unweighted genetic risks, and unweighted lifestyle categories and unweighted genetic risks. Additionally, we added BMI to lifestyle to recalculate this association, considering that some studies counted BMI as a lifestyle factor . We considered a BMI of 18.5 to less than 24 as a healthy lifestyle factor according to the revised Asia-Pacific BMI criteria by the World Health Organization and the National Health Commission of the People’s Republic of China .…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, we added BMI to lifestyle to recalculate this association, considering that some studies counted BMI as a lifestyle factor. 16 , 26 , 27 We considered a BMI of 18.5 to less than 24 as a healthy lifestyle factor according to the revised Asia-Pacific BMI criteria by the World Health Organization 28 , 29 and the National Health Commission of the People’s Republic of China. 27 Furthermore, we analyzed the combination of genetic risk and lifestyle categories with MCI stratified by sex, age, education level, hypertension, and diabetes.…”

Section: Methodsmentioning

confidence: 99%

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Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults

Duan

Zhou

et al. 2023

JAMA Netw Open

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ImportanceApolipoprotein E polymorphism ε4 (APOE ε4) and methylenetetrahydrofolate reductase (MTHFR) TT genotype are genetic risk factors of mild cognitive impairment (MCI), but whether this risk can be changed by modifiable lifestyle factors is unknown.ObjectiveTo explore whether unhealthy lifestyle (unhealthy dietary intake, current smoking, nonlimited alcohol consumption, and irregular physical activities) is associated with a higher risk of age-related MCI considering genetic risk.Design, Setting, and ParticipantsThis population-based cohort study used data from Tianjin Elderly Nutrition and Cognition (TENC) study participants, recruited from March 1, 2018, through June 30, 2021, and followed up until November 30, 2022. Participants were Chinese adults aged 60 years or older who completed the neuropsychological assessments, general physical examinations, and a personal interview.ExposuresHealthy lifestyle was defined according to the Chinese Dietary Guidelines 2022, including healthy diet, regular physical activity, limited alcohol consumption, and no current smoking, categorized into healthy and unhealthy lifestyles according to weighted standardized lifestyle score. Genetic risk was defined by MTHFR TT genotype and APOE ε4, categorized into low and high genetic risk according to weighted standardized genetic risk score.Main Outcomes and MeasuresThe main outcome was newly diagnosed MCI as identified using a modified version of Petersen criteria. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazard regression models.ResultsA total of 4665 participants were included (mean [SD] age, 67.9 [4.9] years; 2546 female [54.6%] and 2119 male [45.4%]); 653 participants with new-onset MCI (mean [SD] age, 68.4 [5.4] years; 267 female [40.9%] and 386 male [59.1%]) were identified after a median follow-up of 3.11 years (range, 0.82-4.61 years). Individuals with a low genetic risk and an unhealthy lifestyle (HR, 3.01; 95% CI, 2.38-3.79), a high genetic risk and a healthy lifestyle (HR, 2.65; 95% CI, 2.03-3.44), and a high genetic risk and an unhealthy lifestyle (HR, 3.58; 95% CI, 2.73-4.69) had a higher risk of MCI compared with participants with a low genetic risk and a healthy lifestyle. There was a synergistic interaction between lifestyle categories and genetic risk (β = 3.58; 95% CI, 2.73-4.69).Conclusions and RelevanceIn this cohort study of TENC participants, the findings show that unhealthy lifestyle and high genetic risk were significantly associated with a higher risk of MCI among Chinese older adults. Unhealthy lifestyle factors were associated with a higher risk of MCI regardless of genetic risk, and lifestyle and genetic risk had synergistic interactions. These findings could contribute to the development of dietary guidelines and the prevention of early-stage dementia.

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“…Amnestic MCI is a subtype of MCI manifesting as a decline in various types of memory (Leyhe et al, 2009 ; Costa et al, 2011 ; Tuena et al, 2021 ). The prevalence of amnestic MCI in people aged ≥60 was 7.4% in South Italy and 17.1% in China (Li et al, 2020 ; Caffo et al, 2022 ). Older patients with amnestic MCI are more likely to progress to Alzheimer’s dementia than those with non-amnestic MCI (Jungwirth et al, 2012 ).…”

Section: Amelioration Of the Clinical Symptoms Of MCI Through Tai Chi...mentioning

confidence: 99%

Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly

Wang¹,

Gu³

et al. 2023

Front. Aging Neurosci.

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Mild cognitive impairment (MCI) is a major public health concern that endangers health and decreases the quality of life of the elderly around the world. A recent clinical guideline has recommended regular exercise (twice per week) for patients with MCI as part of an overall approach to management. Tai Chi, a form of light-to-moderate-intensity mind-body exercise, is particularly suitable for seniors. This review aims to summarize epidemiological studies related to the effects of Tai Chi on symptom remission in older adults with MCI and reveal the potential mechanisms. Evidence suggested that Tai Chi can improve cognitive functions and alleviate the accompanying symptoms of MCI in the elderly potentially by activating the expression of signals in different brain regions, altering their connectivity, increasing the brain volume, and modulating brain-derived neurotropic and inflammation factors. Studies comparing various types of Tai Chi may contribute to the identification of paradigms that have appropriate intensities and difficulty and exert good effects on older people with MCI. In addition, studies are warranted to determine the frequency and duration of training that can optimize the beneficial effects of Tai Chi on MCI.

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The Prevalence of Amnestic and Non-Amnestic Mild Cognitive Impairment and Its Association with Different Lifestyle Factors in a South Italian Elderly Population

Cited by 14 publications

References 78 publications

Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin

Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin

Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults

Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly

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