The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia

Waggass, Rahaf; Alhindi, Abeer K; Bagabas, Inas S; Alsaegh, Mawaddah H; Alsharef, Noor K; Morya, Roaa E; Khan, Muhammad Aqeel; Jastaniah, Wasil

doi:10.7759/cureus.35751

Cureus

2023

DOI: 10.7759/cureus.35751

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The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia

Rahaf Waggass¹,

Abeer K Alhindi²,

Inas S Bagabas³

et al.

Abstract: BackgroundSickle cell disease (SCD) is a common hematological disorder with a high prevalence in Saudi Arabia. Despite that, limited studies are available in our region regarding cardiovascular complications. ObjectivesThe objective of the current study was to estimate the prevalence of cardiovascular complications among children with SCD. DesignThis was a cross-sectional study. SettingThe study took place at a single tertiary-care center in Jeddah, Saudi Arabia.

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2024

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Burden of vaso‐occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients

Seth,

Udupi,

Jain

et al. 2024

Br J Haematol

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SummarySickle cell disease (SCD) with vaso‐occlusive pain crisis (VOC) significantly impacts patient well‐being and often results in extensive healthcare resource utilization. This study assessed the VOC burden, its management and its impact on patients' quality of life (QoL). A cross‐sectional observational study was conducted between November 2021 and June 2022, including 1000 SCD patients from high‐prevalence states in India. Data on demographics, clinical characteristics, VOC severity, management and QoL were collected. The study revealed that 33.5% of patients reported at least one VOC episode during the study period. In the year prior to their enrolment, 836 (83.60%) patients reported at least one VOC episode, with an equal proportion of 407/487 (83.6%) adults and 429/513 (83.6%) paediatric patients, reducing their QoL across all domains compared to patients without VOC. Of these, 469/1000 patients (46.9%) experienced ≥3 VOC episodes. Additionally, 764/1000 (76.40%) patients managed their VOCs at healthcare facilities, with 501/1000 (50.1%) requiring inpatient admissions. Further, 71.80% of patients received Hydroxyurea (HU) therapy. The study depicts the severity of the Arab–Indian haplotype in Indian SCD patients visiting healthcare settings based on high VOC burden. This highlights the urgent need for better management strategies and resource allocation for these patients.

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Burden of vaso‐occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients

Seth,

Udupi,

Jain

et al. 2024

Br J Haematol

View full text Add to dashboard Cite

show abstract

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The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia

Cited by 1 publication

References 22 publications

Burden of vaso‐occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients

Burden of vaso‐occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients

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