The Prevalence of Celiac Disease in Blood Donors in Iceland

Johannsson, Gudmundur; Kristjánsson, Guðjón; Cariglia, Nick; Þorsteinsson, Vigfús

doi:10.1007/s10620-008-0365-0

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…All nine children with doctor-diagnosed CD had undergone blood testing for CD but only 44% had an intestinal biopsy performed. The prevalence of CD in our study was similar to that in other industrialised countries,3–5 as well as a previous study in the adult New Zealand population 9. The only prior publication on CD prevalence among New Zealand children,10 which was conducted more than two decades ago, showed a significantly lower prevalence of CD (0.014%) compared to our study, a difference that suggests significant under-ascertainment in the earlier study or significant increases in the incidence and general awareness of CD.…”

Section: Discussionsupporting

confidence: 89%

“…In summary, we found that the prevalence of doctor-diagnosed CD in New Zealand children is similar to that in adult New Zealanders and the population prevalence in other industrialised countries 3–5 9. We also found that gluten avoidance was five times more common than the prevalence of doctor-diagnosed CD.…”

Section: Discussionsupporting

confidence: 70%

“…Population screening studies have suggested a prevalence of approximately 1%, which makes CD one of the most common genetically determined diseases in humans 3–5. CD is also an often cited example of the ‘iceberg’ phenomenon because of the assumed large number of undiagnosed CD cases in the general population 6 7.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coeliac disease and gluten avoidance in New Zealand children

Tanpowpong

Ingham²,

Lampshire³

et al. 2011

Arch Dis Child

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 70%

See 1 more Smart Citation

Coeliac disease and gluten avoidance in New Zealand children

Tanpowpong

Ingham²,

Lampshire³

et al. 2011

Arch Dis Child

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show abstract

“…11 These data and previous reports of high prevalence of CD in the “Fertile Crescent” challenges the hypothesis of a Middle East-Europe CD prevalence gradient attributable to a lack of exposure to cereals until relatively recently (Simoons’ hypothesis).…”

Section: Introductionmentioning

confidence: 82%

Celiac disease

Rubio–Tapia

Murray

2010

Current Opinion in Gastroenterology

139

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Purpose of review To summarize recent advances in celiac disease (CD) published between August 2008 and July 2009. Recent findings CD affects ~1% of most populations but remains largely unrecognized. In the last year, work has shown that the prevalence of CD has increased dramatically, not simply due to increased detection. Also, undiagnosed CD may be associated with increased mortality. Significant progress has been made in understanding how gliadin peptides can cross the intestinal border and access the immune system. New genetic loci and candidate genes that may contribute to the risk of CD and its overlap with type 1 diabetes mellitus have been identified. New deamidated gliadin peptides antibodies have better diagnostic accuracy over native gliadin-based tests. The inclusion of duodenal bulb biopsy specimens may increase the rate of CD detection. The spectrum of CD likely includes a minority of patients with mild enteropathy. A practical 7-item instrument may facilitate standardized evaluation of gluten-free diet adherence. Finally, refractory CD, whilst rare, is associated with a poor prognosis. Summary Celiac disease is a global health problem that requires a multidisciplinary and increasingly cooperative multinational research effort.

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“…There were 15 studies on blood donors, which fulfilled our inclusion criteria. [84][85][86][87][88][89][90][91][92][93][94][95][96][97][98] The prevalence of CD in blood donors based on EMA was 0.21-1.34%, 0.14-7.01% based on elevated tTG levels, while 0-0.62% had Marsh 3 lesions. Twenty-nine studies on first-degree relatives fulfilled our inclusion criteria.…”

Section: Incidence and Prevalence Of Clinically Diagnosed CD (Tables mentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

231

182

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Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

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The Prevalence of Celiac Disease in Blood Donors in Iceland

Abstract: Prevalence of celiac disease in Iceland is similar to what has been reported in many other countries.

Cited by 14 publications

References 16 publications

Coeliac disease and gluten avoidance in New Zealand children

Coeliac disease and gluten avoidance in New Zealand children

Celiac disease

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

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