2015
DOI: 10.5114/pr.2015.51627
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The prevalence of combined pro-thrombotic polymorphisms in patients with recurrent deep vein thrombosis – does genetic testing provide any benefit?

Abstract: Introduction: Deep vein thrombosis (DVT) constitutes a serious clinical, social, and economic problem. Factors predisposing to DVT development include acquired (immobilisation, injury) and inherited (genetic thrombophilia) forms. However, DVT itself is also the risk factor for disease recurrence. Diagnostic algorithms for DVT concern ultrasound examination and D-dimer measurement. Genetic tests, although potentially useful, are not performed routinely. Therefore, the aim of the study was to evaluate whether ge… Show more

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“…Thrombophilia is a risk factor of thrombosis, which has been reported in 18.8% to 46% of young patients with DVT and may increase risk of relapse DVT [ 12 , 31 , 32 ]. Genetic testing for FV R506Q, PT G20210A, and MTHFR C677T is recommended for patients after the first episode of unprovoked DVT, and the results may be beneficial to protect from recurrence [ 33 ]. In the present study, thrombophilia was not screened among these patients, which may be a defect in our study.…”
Section: Short-term Anticoagulant Therapy As a Risk Factor For Delayementioning
confidence: 99%
“…Thrombophilia is a risk factor of thrombosis, which has been reported in 18.8% to 46% of young patients with DVT and may increase risk of relapse DVT [ 12 , 31 , 32 ]. Genetic testing for FV R506Q, PT G20210A, and MTHFR C677T is recommended for patients after the first episode of unprovoked DVT, and the results may be beneficial to protect from recurrence [ 33 ]. In the present study, thrombophilia was not screened among these patients, which may be a defect in our study.…”
Section: Short-term Anticoagulant Therapy As a Risk Factor For Delayementioning
confidence: 99%