The prevalence of developmental anomalies among school children in Southern district of Andhra Pradesh, India

Bandaru, Brijesh Krishna; Thankappan, Prasanth; Nandan, Surapaneni Ratheesh Kumar; Arora, Rajesh; Annem, Sudarshan Kumar; Santosh, Arvind Babu Rajendra

doi:10.4103/jomfp.jomfp_119_18

Cited by 14 publications

(1 citation statement)

References 28 publications

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“…[ 18 ] and Bandaru et al . [ 19 ] among Indian population also showed isolated forms are more common than syndromic-associated dental anomalies. The reason behind this dissimilarity of reported isolated anomalies may be associated with differences in population group, sample size considerations, examination methods, inclusion and exclusion criteria, not taking into account of environmental or local factors such as medications, systemic diseases associated, vaccination against rubella or varicella acquired by the mother at the time of pregnancy/delivery and even ancestral alterations between the studied population.…”

Section: Discussionmentioning

confidence: 99%

Consanguineous marriage as a key indicator of isolated congenital dental anomaly among South Indian population – A cross-sectional study

Rajeswari

Ramamoorthy

Rajakumar

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Background: Orofacial anomalies occur due to incomplete fusion of developmental lines in the head and neck region. Dental anomalies regarded as the most common orofacial anomalies either in isolated or syndromic forms arise due to genetic and environmental factors. Among genetic influences, consanguineous marriages are considered as a significant predisposition factor in the transmission of congenital defects and several autosomal recessive diseases from one generation to other with an increased risk of detrimental effects on offspring. Aim: The present study was aimed to evaluate the prevalence and significant association between consanguinity and isolated dental anomalies with that of nonconsanguineous parents among south-Indian population. Methodology: A total of 116 participants with and without dental anomalies in isolated form pertaining to tooth size, shape, altered morphology, number and eruption were selected followed by brief case history. Participants with a positive history of consanguinity were categorized as Group A while others were categorized under Group B. Results: Sixty-four out of 116 participants (55.17%) showed positive consanguinity (Group A) among which 18 females (56%) and 14 males (44%) presented with isolated dental anomalies. 12 females (66.6%) and 9 males (64.2%) in Group A showed significance with first cousin ( P = 0.00204) whereas no significance was observed in other consanguinity type ( P = 0.7287). Nonetheless, the overall frequency of isolated dental anomalies was slightly higher in Group A than Group B that was statistically significant ( P = 0.0213). Conclusion: A positive correlation between dental anomalies among offspring of consanguineous marriages revealed such prevalence may be attributed to increased risk of recessive deleterious gene expression or defective allele carried to offspring.

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Section: Discussionmentioning

confidence: 99%