The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population‐based study in a Western European country

Picot, Marie‐Christine; Baldy-Moulinier, M; Daurès, Jean‐Pierre; Dujols, Pierre; Crespel, Arielle

doi:10.1111/j.1528-1167.2008.01579.x

Cited by 385 publications

(258 citation statements)

References 35 publications

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“…The prevalence of active epilepsy (patients with at least one seizure in the past 5 years), is 0.4–1.0% worldwide 1. In a study of one city in France, Picot et al 1.…”

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confidence: 99%

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Detection of generalized tonic–clonic seizures using surface electromyographic monitoring

et al. 2017

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SummaryObjectiveA prospective multicenter phase III trial was undertaken to evaluate the performance and tolerability in the epilepsy monitoring unit (EMU) of an investigational wearable surface electromyographic (sEMG) monitoring system for the detection of generalized tonic–clonic seizures (GTCSs).MethodsOne hundred ninety‐nine patients with a history of GTCSs who were admitted to the EMU in 11 level IV epilepsy centers for clinically indicated video‐electroencephalographic monitoring also received sEMG monitoring with a wearable device that was worn on the arm over the biceps muscle. All recorded sEMG data were processed at a central site using a previously developed detection algorithm. Detected GTCSs were compared to events verified by a majority of three expert reviewers.ResultsFor all subjects, the detection algorithm detected 35 of 46 (76%, 95% confidence interval [CI] = 0.61–0.87) of the GTCSs, with a positive predictive value (PPV) of 0.03 and a mean false alarm rate (FAR) of 2.52 per 24 h. For data recorded while the device was placed over the midline of the biceps muscle, the system detected 29 of 29 GTCSs (100%, 95% CI = 0.88–1.00), with a detection delay averaging 7.70 s, a PPV of 6.2%, and a mean FAR of 1.44 per 24 h. Mild to moderate adverse events were reported in 28% (55 of 199) of subjects and led to study withdrawal in 9% (17 of 199). These adverse events consisted mostly of skin irritation caused by the electrode patch that resolved without treatment. No serious adverse events were reported.SignificanceDetection of GTCSs using an sEMG monitoring device on the biceps is feasible. Proper positioning of this device is important for accuracy, and for some patients, minimizing the number of false positives may be challenging.

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“…The prevalence of active epilepsy (patients with at least one seizure in the past 5 years), is 0.4–1.0% worldwide 1. In a study of one city in France, Picot et al 1.…”

mentioning

confidence: 99%

“…In a study of one city in France, Picot et al 1. found that 37.5% of patients with active epilepsy had suffered at least one generalized tonic–clonic seizure (GTCS).…”

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confidence: 99%

Detection of generalized tonic–clonic seizures using surface electromyographic monitoring

et al. 2017

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“…D'une part, leur effet prolongé ne permet pas de limiter leur action à la durée d'une crise, de sorte que la prise d'antiépileptiques affecte le fonctionnement normal du cerveau entre les ictus, donnant lieu à des effets secondaires indésirables (vertiges, somnolence, troubles de la vision). D'autre part, ces médicaments ont une action limitée face à la diversité des types cliniques d'épi-lepsie, dont on considère classiquement qu'au moins 20 à 30 % sont -ou deviennent -réfractaires au traitement (on parle d'épilepsie pharmaco-résistante) [41]. La neurochirurgie résective constitue actuellement la principale option alternative pour les patients pharmaco-résistants.…”

Section: Approches Optogénétiques Dans Le Traitement De L'épilepsieunclassified

Potentiel thérapeutique de la neuromodulation optogénétique

et al. 2015

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“…Of the remaining percentage, approximately 30 % will be assigned to a more specific category within 2 years [8]. Approximately 20 to 30 % of patients with epilepsy have refractory epilepsy (i.e., seizures that persist, despite accurate diagnosis and carefully monitored treatment with antiepileptic drugs) [9]. Knowledge of the pathophysiology of childhood epilepsy has considerably increased with improvement of both neuroimaging and genetic techniques.…”

Section: Introductionmentioning

confidence: 99%

Novel Animal Models of Pediatric Epilepsy

et al. 2012

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When mimicking epileptic processes in a laboratory setting, it is important to understand the differences between experimental models of seizures and epilepsy. Because human epilepsy is defined by the appearance of multiple spontaneous recurrent seizures, the induction of a single acute seizure without recurrence does not constitute an adequate epilepsy model. Animal models of epilepsy might be useful for various tasks. They allow for the investigation of pathophysiological mechanisms of the disease, the evaluation, or the development of new antiepileptic treatments, and the study of the consequences of recurrent seizures and neurological and psychiatric comorbidities. Although clinical relevance is always an issue, the development of models of pediatric epilepsies is particularly challenging due to the existence of several key differences in the dynamics of human and rodent brain maturation. Another important consideration in modeling pediatric epilepsy is that "children are not little adults," and therefore a mere application of models of adult epilepsies to the immature specimens is irrelevant. Herein, we review the models of pediatric epilepsy. First, we illustrate the differences between models of pediatric epilepsy and models of the adulthood consequences of a precipitating insult in early life. Next, we focus on new animal models of specific forms of epilepsies that occur in the developing brain. We conclude by emphasizing the deficiencies in the existing animal models and the need for several new models.

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The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population‐based study in a Western European country

Cited by 385 publications

References 35 publications

Detection of generalized tonic–clonic seizures using surface electromyographic monitoring

Detection of generalized tonic–clonic seizures using surface electromyographic monitoring

Potentiel thérapeutique de la neuromodulation optogénétique

Novel Animal Models of Pediatric Epilepsy

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