The prevalence of exfoliation syndrome in Turkey

Kılıç, Raşit; Karagöz, Naim; Çetin, Abdi Bahadır; Çakmak, Yasin; Sezer, Hafize; Özay, Yusuf; Çomçalı, Sebile; Dursun, Ayhan

doi:10.1111/aos.12885

Cited by 13 publications

(16 citation statements)

References 33 publications

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“…This ratio was around the highest ratios reported so far. PSXG patients comprised the oldest patients in the overall group and, similar to a previous study from Turkey, there was male preponderance [24]. Bilateral involvement in these patients was present in 77% of our series, similar to the previous reports [16,23].…”

Section: Ankara Is the Capital And The Second Largest City Of Turkey supporting

confidence: 92%

“…In Greece, another neighbor to the west of Turkey however, clinic-based study revealed that PSXG is probably responsible for the majority of severe cases of glaucoma [23]. In a recent population-based study, PSX syndrome has been shown to be common in Turkey [24]. In a study from Eastern Mediterranean area of Turkey, percentage of PSX syndrome in patients with open-angle glaucoma was 46.9% [25].…”

Section: Ankara Is the Capital And The Second Largest City Of Turkey mentioning

confidence: 99%

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Glaucoma Profile at the Tertiary Ophthalmic Centers in Ankara, Turkey

Bayer

Elgin

Tekeli

et al. 2021

Preprint

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Purpose: This study aimed to investigate the demographic and clinical characteristics of the patients with glaucoma, who presented at the tertiary ophthalmology clinics in Ankara, Turkey.Patients and Methods: This cross-sectional study included all of the consecutive glaucoma patients or glaucoma suspects who presented at ten different tertiary ophthalmology clinics in Ankara between March 2015 and May 2015. The demographic characteristics and clinical findings of the patients were evaluated. Glaucoma was diagnosed according to the International Society for Geographical and Epidemiological Ophthalmology Classification. In the patients with binocular glaucoma, only the data of the worse eye was included for statistical analyses. Results: A total of 4604 eyes of 2541 patients fulfilled the inclusion criteria and were classified as having glaucoma. Binocular involvement was present in 2063 (81.2%) patients. Primary open angle glaucoma (POAG) was the most common glaucoma type (38.8%), followed by exfoliative glaucoma (XFG; 26.2%), and primary angle-closure glaucoma (PACG; 7.7%). The distribution of the sexes was significantly different among the diagnosis groups (P < 0.001). The cup/disk ratio was the highest among the patients with secondary angle-closure glaucoma (SACG; P < 0.001). The visual field MD parameter was significantly higher in the patients with SACG and XFG (P < 0.001). Monocular and binocular blindness ratios were 21% and 2.8%, respectively.Conclusions: The predominant type of glaucoma in Turkish clinic patients was found to be POAG, followed by XFG and PACG.

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Section: Ankara Is the Capital And The Second Largest City Of Turkey supporting

confidence: 92%

Section: Ankara Is the Capital And The Second Largest City Of Turkey mentioning

confidence: 99%

Glaucoma Profile at the Tertiary Ophthalmic Centers in Ankara, Turkey

Bayer

Elgin

Tekeli

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Other researchers also found similar trends in the interactions between AH and the PEX [7,31]. This may be due to the fact that persons with AH have effectively controlled their blood pressure, thereby reducing the risk of developing the PEX.…”

Section: Discussionmentioning

confidence: 56%

“…The opposite results were found in Turkey, where higher rates of cerebrovascular disease in the PEX group were observed [28]. Many studies did not find any significant differences between the rates of AH and the PEX [7,15,[29][30][31]. In the followup study, we could not confirm the baseline data of the significant association of the rates of AH and higher systolic blood pressure with the PEX because of the small size of the sample and a higher number of risk factors in older age [9].…”

Section: Discussionmentioning

confidence: 72%

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Link of ocular pseudoexfoliation syndrome and vascular system changes: results from 10-year follow-up study

et al. 2020

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Purpose To examine the 10-year incidence of the pseudoexfoliation syndrome (PEX) in adults in a population-based follow-up study, to determine its link with vascular diseases, and to identify possible risk factors of the PEX. Methods The baseline examination was performed in 2006 on a random sample of 1033 participants from Kaunas city (Lithuania) population. In 2016, a followup study of 686 participants who returned for the examination was conducted. The respondents filled out a questionnaire, an ophthalmological examination was performed, and the presence of vascular diseases was determined by the anamnesis and electrocardiogram evaluation data. Binary univariate and multivariate logistic regression analyses were conducted with the PEX and vascular diseases as predictors, controlling for age. Odds ratios (OR) and 95% confidence intervals of OR were calculated for the risk of new PEX cases. Results During 10 years, the prevalence of the PEX in the study population increased from 10.3 to 34.2%. The rates of ischemic heart disease (IHD) and IHD combined with stroke were significantly higher in the PEX subjects than in the non-PEX subjects. The risk of the PEX among persons with IHD was, on the average, by 1.5-fold higher, and among those with IHD and stroke, on the average, by 1.6-fold higher as compared to persons without the aforementioned pathologies (accordingly, p = 0.014 and p = 0.010). Conclusion The prevalence of the PEX increased significantly with age. The risk of the PEX was significantly higher among persons with IHD and even higher among persons with IHD and stroke. In the future, a greater understanding of the cardiovascular, metabolic, and environmental components associated with the PEX may lead to more specific lifestylerelated preventive strategies to decrease the disease burden.

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Secondary glaucoma: Toward interventions based on molecular underpinnings

Mueller,

Lam,

Kishor

et al. 2023

WIREs Mechanisms of Disease

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Glaucoma is a heterogeneous group of progressive diseases that leads to irreversible blindness. Secondary glaucoma refers to glaucoma caused by a known underlying condition. Pseudoexfoliation and pigment dispersion syndromes are common causes of secondary glaucoma. Their respective deposits may obstruct the trabecular meshwork, leading to aqueous humor outflow resistance, ocular hypertension, and optic neuropathy. There are no disease‐specific interventions available for either. Pseudoexfoliation syndrome is characterized by fibrillar deposits (pseudoexfoliative material) on anterior segment structures. Over a decade of multiomics analyses taken together with the current knowledge on pseudoexfoliative glaucoma warrant a re‐think of mechanistic possibilities. We propose that the presence of nucleation centers (e.g., vitamin D binding protein), crosslinking enzymes (e.g., transglutaminase 2), aberrant extracellular matrix, flawed endocytosis, and abnormal aqueous‐blood barrier contribute to the formation of proteolytically resistant pseudoexfoliative material. Pigment dispersion syndrome is characterized by abnormal iridolenticular contact that disrupts iris pigment epithelium and liberates melanin granules. Iris melanogenesis is aberrant in this condition. Cytotoxic melanogenesis intermediates leak out of melanosomes and cause iris melanocyte and pigment epithelium cell death. Targeting melanogenesis can likely decrease the risk of pigmentary glaucoma. Skin and melanoma research provides insights into potential therapeutics. We propose that specific prostanoid agonists and fenofibrates may reduce melanogenesis by inhibiting cholesterol internalization and de novo synthesis. Additionally, melatonin is a potent melanogenesis suppressor, antioxidant, and hypotensive agent, rendering it a valuable agent for pigmentary glaucoma. In pseudoexfoliative glaucoma, where environmental insults drive pseudoexfoliative material formation, melatonin's antioxidant and hypotensive properties may offer adjunct therapeutic benefits.This article is categorized under: Neurological Diseases > Molecular and Cellular Physiology

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The prevalence of exfoliation syndrome in Turkey

Cited by 13 publications

References 33 publications

Glaucoma Profile at the Tertiary Ophthalmic Centers in Ankara, Turkey

Glaucoma Profile at the Tertiary Ophthalmic Centers in Ankara, Turkey

Link of ocular pseudoexfoliation syndrome and vascular system changes: results from 10-year follow-up study

Secondary glaucoma: Toward interventions based on molecular underpinnings

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