The prevalence of facial acne in Peruvian adolescents and its relation to their ethnicity

Freyre, Eleodoro A.; Rebaza, Rodolfo M; Sami, David A; Lozada, Claudia P

doi:10.1016/s1054-139x(97)00277-2

Cited by 49 publications

(49 citation statements)

References 13 publications

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“…Classic twin [6 -8,10,11] and population-based studies [13][14][15][16][17][18][19] provided unambiguous evidence concerning the role of inherited factors in the pathogenesis of acne. Cross-sectional and population-based investigations have yielded clear evidence on the exact course of the disease and the differences that can be observed in different populations.…”

Section: Discussionmentioning

confidence: 99%

“…In the developed world, acne vulgaris affects 80 to 90% of the population [13], whereas in less modernized civilizations, where the population lives a more natural, less industrialized lifestyle, the proportion of affected individuals tends to be much lower. There are even isolated populations where acne is nonexistent, including the inhabitants of the island of Okinawa before World War II [14], the Bantus in South Africa [15,16], the Eskimos [17], isolated South American Indians [18], and Pacific Islanders [19].…”

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

“…Cross-sectional studies in developed countries involving adolescent schoolchildren in many different locations have revealed that the prevalence of acne progressively increases during the teenage years [18]. The less severe comedonic forms are more prevalent in the general population.…”

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

“…The less severe comedonic forms are more prevalent in the general population. The symptoms usually start around the age of 10 to 12 and gradually increase until the age of 16 to 18 [13,18,29,30]. At around age 12 the prevalence of the disease is higher in females, but this trend later reverses.…”

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

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Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

Szabó

Kemény

2011

Human Immunology

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A B S T R A C TAcne is one of the most common dermatologic diseases in the developed regions of the world, affecting a large percentage of the population. Despite the great improvement in the number and quality of studies of the molecular etiology of this disease in the past 3 decades, the detailed molecular pathogenesis and the cause of the large individual variations in severity of skin symptoms remain unknown. The roles of genetic inheritance and special genetic susceptibility and protective factors have been suggested for over 100 years, but their identification and determination started only in the 1990s. To date, only a small number of genetic polymorphisms affecting the expression and/or function of a handful of genes have been investigated. This review surveys the major findings of the classic and molecular genetic studies that have been conducted in this field, draws conclusions, and indicates how the available data help our current understanding of the pathogenesis of this common skin disease. ᭧

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Section: Discussionmentioning

confidence: 99%

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

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Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

Szabó

Kemény

2011

Human Immunology

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“…The prevalence of acne varies by age and ethnicity [2][3][4] . A community-based study performed in China found that acne was present in subjects older than 10 years of age and that the prevalence increased rapidly with age up to 46.8% in the19-year-old group 5 .…”

mentioning

confidence: 99%

Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

Yang

et al. 2014

Nat Commun

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Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, P combined ¼ 4.41 Â 10 À 9 and rs1060573, P combined ¼ 1.28 Â 10 À 8 ) and 1q24.2 (SELL, rs7531806, P combined ¼ 1.20 Â 10 À 8 ) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne.

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