The Prevalence of Gastric Intestinal Metaplasia and Distribution of<i>Helicobacter pylori</i>Infection, Atrophy, Dysplasia, and Cancer in Its Subtypes

Ölmez, Şehmus; Aslan, Mehmet; Erten, Remzi; Sayar, Süleyman; Bayram, İrfan

doi:10.1155/2015/434039

Cited by 48 publications

(36 citation statements)

References 33 publications

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“…In the presence of H. pylori, the prevalence of atrophy was 2.5 times higher (17.6 vs 6.9%) and metaplasia was 1.3 times higher (17.7 vs 13.3%) compared to H. pylori (-) patients. These results are in accordance with several studies (16,(33)(34)(35) and also with the findings of the meta-analysis mentioned above in which the prevalence of the atrophy was 2.7 times higher and metaplasia was 2.1 times higher in individuals infected by H. pylori than in uninfected individuals (30) . In the current study the percentage difference between H. pylori (+) and H. pylori (-) patients was higher in atrophy than in metaplasia.…”

Section: Discussionsupporting

confidence: 93%

Helicobacter Pylori Infection and Gastric Cancer Precursor Lesions: Prevalence and Associated Factors in a Reference Laboratory in Southeastern Brazil

Rodrigues

Guerra

Alvarenga

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Helicobacter pylori infection is the most important risk factor for gastric atrophy and intestinal metaplasia, both considered gastric cancer precursor lesions. Therefore, the investigation of the occurrence of H. pylori infection, precursor lesions and associated factors guides the adoption of specific strategies for the control this type of cancer. OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients undergoing upper digestive endoscopy, as well as the prevalence of intestinal metaplasia, atrophy and chronic inflammation and their association with H. pylori infection. METHODS: A retrospective study was performed based on reports of gastric endoscopic biopsies performed in a private laboratory affiliated to the Brazilian Public Health System (SUS). Patients were evaluated for age, gender and type of health service. The samples were evaluated for the presence of H. pylori, and also of chronic inflammation, intestinal metaplasia and glandular atrophy. RESULTS: Of a total of 4,604 patients (mean age 51±16.6), 63.9% were female and 63.1% coming from private health care service. The prevalence of H. pylori infection was 31.7% (n=1,459), and the percentage of infection was significantly higher in patients from public health service (42.0%) in relation to patients from private health service (25.6%). Among H. pylori (+) patients, a higher percentage of intestinal metaplasia (17.7% vs 13.3%) and glandular atrophy (17.6% vs 6.9%) were observed when compared to those H. pylori (-) (P<0.01). From the patients H. pylori (+) with at least one type of precursor lesion (n=418), 161 (38.5%) had metaplasia and chronic inflammation, 160 (38.3%) had atrophy and chronic inflammation and finally 97 (23.2%) presented metaplasia, atrophy and chronic inflammation simultaneously. CONCLUSION: The present study reinforces the association of H. pylori infection with gastric cancer precursor lesions in a Brazilian population, emphasizing the importance of infection prevention measures, as well as the treatment of infected patients, especially in regions with lower socioeconomic levels that show a higher prevalence of infection by H. pylori.

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Section: Discussionsupporting

confidence: 93%

Helicobacter Pylori Infection and Gastric Cancer Precursor Lesions: Prevalence and Associated Factors in a Reference Laboratory in Southeastern Brazil

Rodrigues

Guerra

Alvarenga

et al. 2019

Arq. Gastroenterol.

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“…In the current study, CAG was significantly associated with H. pylori, and is a good suggestion for the causative role of H. pylori in chronic active gastritis. Many clinical studies reported that H. pylori is significantly associated with CAG, atrophic gastritis, intestinal metaplasia and gastric cancer ( 42 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with H. pylori infection in Saudi patients with dyspepsia

Akeel¹,

Elmakki²,

Shehata³

et al. 2018

Electron Physician

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BackgroundHelicobacter pylori (H. pylori) is a major cause of peptic ulcer disease (PUD) and chronic active gastritis that may progress to gastric cancer. Globally, it has been estimated that 50% or more of the world’s population is infected by H. pylori, making it the most widespread infection across the globe.ObjectivesTo determine the prevalence of H. pylori infection and to identify factors associated with H. pylori infection in Saudi patients presenting with dyspepsia.MethodsIn this prospective cross-sectional study, a total of 404 gastric biopsies were endoscopically obtained from 404 patients with dyspepsia from September 2014 to April 2016 (Jazan Province, Saudi Arabia). The specimens were analyzed using the real-time polymerase chain reaction (PCR). The data was examined using descriptive statistics as well as determining the prevalence, and employing Chi square and Fisher exact test. A p-value of ≤0.05 was considered statistically significant in examining the research hypotheses.ResultsThe overall prevalence of H. pylori in Jazan Province was 46.5% (95% CI: 41.7–51.4) and the prevalence was lower among those > 55 years old. Prevalence was higher among urban (50.0%; 95% CI: 43.1–56.8) versus rural (42.1%; 95% CI: 35.1–49.3), but with no significant difference. Prevalence did not show significant difference among different Body Mass Index (BMI) categories, ranging from 40.2% to 47.7%. The prevalence of H. pylori in females was 47.1% (95% CI: 40.4–53.9) versus 45.6% (95% CI: 38.7–52.6) in males. Histopathology findings were associated with H. pylori infection with prevalence of 58.1% among patients with chronic active gastritis, compared to 24.1% and 34.8% among mild and chronic gastritis, respectively.ConclusionOur results indicate that there is a high prevalence of H. pylori among Saudi patients with dyspepsia. Prevalence of H. pylori was high in ages below 55 years. Chronic active gastritis was significantly associated with H. pylori infection. In depth studies are needed to determine associated factors with of H pylori infection in the region

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“…H. pylori infection is a main factor leading to atrophy, intestinal metaplasia, and cancer development in the stomach [ 23 ]. In the present study, 512 patients with gastric cancer had been checked for the presence of H. pylori.…”

Section: Resultsmentioning

confidence: 99%

Should every region use the same gastric cancer scanning and treatment approaches? let’s reconsider: a northeastern turkey example

et al. 2016

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BackgroundThe rate for upper gastrointestinal (UGI) cancers, and especially the rate for gastric cancer, varies from country to country and from region to region within country. In Turkey, the incidence of gastric cancer varies widely among regions due to the diverse cultures and accompanying food habits of the population. This study aimed to determine the endoscopic frequency of esophageal and gastric cancers and the usefulness of alarm symptoms in diagnosing gastric cancer in subjects undergoing endoscopy in northeastern Turkey.MethodsThis retrospective study was based on hospital records, reviewing the records of patients who had underdone esophago-gastro-duodenal (EGD) video endoscopy at two general hospitals in Erzurum. From July 2010 to January 2013, 25,037 patients from Erzurum underwent EGD procedures under either intravenous sedation or local anesthesia. Classifications of UGI cancer, based on location of the tumor, were defined as esophageal, cardia, cardia and fundus or corpus or all of these, corpus, corpus and antrum, and antrum. Metastasis was studied in 659 patients diagnosed with cancer.ResultsThroughout the study, 1,007 biopsy samples were reported as malignant tumors (719 gastric, 276 esophageal, and 12 duodenal cancers). The study considered the gastric cancer population under age 46, which included 99 (13.8 %) patients. Among them, the distribution of UGI cancer by age was as follows: under age 26 years, 9 patients (0.9 %); age 26–35 years, 30 patients (3 %); and age 36–45 years, 60 patients (6 %). Overall, 298 patients (298/1007, 29.6 %) presented with localized disease, and 361 patients (35.9 %) had distant metastases at the time of diagnosis.ConclusionsWe determined that UGI cancer patients are observed more frequently in northeastern Turkey than in western Turkey, Europe, and the USA. We believe that alarm symptoms and endoscopic scanning programs require new, region-specific criteria to diagnose UGI cancers in this region. For the patient groups with these different characteristics, we believe that new scanning, follow-up, and treatment strategies are needed that take into consideration differences in the histopathology of the tumors, their localization, and the patients’ ages.Trial registrationThere is registration number. This study is “retrospective study”. This study is “retrospectively registered”.

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The Prevalence of Gastric Intestinal Metaplasia and Distribution ofHelicobacter pyloriInfection, Atrophy, Dysplasia, and Cancer in Its Subtypes

Cited by 48 publications

References 33 publications

Helicobacter Pylori Infection and Gastric Cancer Precursor Lesions: Prevalence and Associated Factors in a Reference Laboratory in Southeastern Brazil

Helicobacter Pylori Infection and Gastric Cancer Precursor Lesions: Prevalence and Associated Factors in a Reference Laboratory in Southeastern Brazil

Prevalence and factors associated with H. pylori infection in Saudi patients with dyspepsia

Should every region use the same gastric cancer scanning and treatment approaches? let’s reconsider: a northeastern turkey example

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