The Prevalence of Gastrointestinal Problems in Children Across the United States With Autism Spectrum Disorders From Families With Multiple Affected Members

Wang, Lulu W.; Tancredi, Daniel J.; Thomas, Dan W.

doi:10.1097/dbp.0b013e31821bd06a

Cited by 215 publications

(166 citation statements)

References 30 publications

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“…Similarly, Molloy and Manning-Courtney (2003) found that frequency of gastrointestinal symptoms did not vary by age, gender, race or severity of autism. In contrast, Wang, Tancredi and Thomas (2011) found that increased autism severity is associated with increased odds of having GI problems. Nikolov et al (2009) also found no difference between those with and without GI problems, based on demographic characteristics or measures of adaptive functioning.…”

mentioning

confidence: 47%

An analysis of the predictors of comorbid psychopathology, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder

Mannion

Leader

2013

Research in Autism Spectrum Disorders

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mentioning

confidence: 47%

An analysis of the predictors of comorbid psychopathology, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder

Mannion

Leader

2013

Research in Autism Spectrum Disorders

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“…This study was registry-based and the investigators conducted in-home structured medical history interviews by parent recall. Those children with classic autism had increased odds of having GI problems compared to less severely affected children with ASD [12].…”

Section: Introductionmentioning

confidence: 94%

“…Although opinions differ, a majority of published studies on the subject of childhood autism and gastrointestinal problems report higher rates of feeding problems in children with ASD compared to controls [5][6][7][8][9][10][11][12][13]. The Brief Autism Mealtime Behavior Inventory (BAMBI) has been developed to evaluate the mealtime behavior of children with autism [14].…”

Section: Introductionmentioning

confidence: 99%

Feeding problems and GI dysfunction in children with asperger syndrome or pervasive developmental disorder not otherwise specified; comparison with their siblings

Badalyan¹,

Schwartz²

2011

OJPed

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“…The reported prevalence of any GI disorder in children with ASDs ranges from 9% to 91% (see Fig 1), abdominal pain or discomfort ranges from 2% to 41%, constipation from 6% to 45%, diarrhea from 3% to 77%, and persistent diarrhea from 8% to 19% 3,9,[11][12][13][14][15][16][17][18][19][20][21] . Although all the studies have significant methodological limitations, they collectively indicate unusually high rates of GI disorders or certain GI symptoms in children with ASDs and higher rates in all but one study when a control population was used.…”

Section: Epidemiology Of Gi Conditions In Asdsmentioning

confidence: 99%

Gastrointestinal Conditions in Children With Autism Spectrum Disorder: Developing a Research Agenda

et al. 2012

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Autism spectrum disorders (ASDs) are a set of complex neurodevelopmental disorders defined behaviorally by impaired social interaction, delayed and disordered language, repetitive or stereotypic behavior, and a restricted range of interests. ASDs represent a significant public health issue with recent estimates indicating that as many as 1% of children in the United States are diagnosed with an ASD. 1,2 Many individuals with ASDs have symptoms of associated medical conditions, including seizures, sleep problems, metabolic conditions, and gastrointestinal (GI) disorders, which have significant health, developmental, social, and educational impacts. Gastrointestinal complaints are a commonly reported concern for parents and may be related to problem behaviors and other medical issues such as dysregulated sleep (ATN Annual Registry Report, unpublished data, November 2009). 3 Despite the magnitude of these issues, potential GI problems are not routinely considered in ASD evaluations. This likely reflects several factors, including variability in reported rates of GI disorders, controversies regarding the relationship between GI symptoms and the putative causes of autism, the limited verbal capacity of many ASD patients, and the lack of recognition by clinicians that certain behavioral manifestations in children with ASDs are indicators of GI problems (eg, pain, discomfort, or nausea). [4][5][6][7][8][9][10] Whether GI issues in this population are directly related to the pathophysiology of autism, or are strictly a comorbid condition of ASD remains to be determined, but clinical practice and research to date indicate the important role of GI conditions in ASDs and their impact on children as well as their parents and clinicians. 9 On November 15, 2009, a symposium addressing these issues was organized as an adjunct to the annual meeting of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. A panel of international experts presented the latest scientific information on pathophysiology, evaluation, and treatment strategies for GI conditions in children and adolescents with ASDs. One aim of the meeting was to raise awareness among gastroenterologists and GI researchers of GI disorders in the ASD population and to provide clinicians with information to improve their clinical practice for these children. The symposium addressed 4 major areas of concern for children with ASDs: reflux, constipation, diarrhea, and nutrition. Each session reviewed the state of the evidence, the latest findings on issues such as intestinal permeability, inflammatory processes, innervation, motility, nutrition, and the epidemiology, presentation, and clinical management of GI issues.The symposium also set the context for a follow-up workshop on November 16 that focused on identifying and prioritizing the key research topics for further investigation. The 1-day workshop brought together AUTHORS:

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The Prevalence of Gastrointestinal Problems in Children Across the United States With Autism Spectrum Disorders From Families With Multiple Affected Members

Abstract: : Parents report significantly more GI problems in children with familial ASD, especially those with Full Autism, than in their unaffected children. Increased autism symptom severity is associated with increased odds of having GI problems.

Cited by 215 publications

References 30 publications

An analysis of the predictors of comorbid psychopathology, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder

An analysis of the predictors of comorbid psychopathology, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder

Feeding problems and GI dysfunction in children with asperger syndrome or pervasive developmental disorder not otherwise specified; comparison with their siblings

Gastrointestinal Conditions in Children With Autism Spectrum Disorder: Developing a Research Agenda

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