The prevalence of gout in an urban area of Izmir, Turkey: A population-based epidemiological study

Bırlık, Merih; Gürler, Oğuz; Akar, Servet; Sarı, İ̇smail; Önen, Fatoş; Akkoç, Nurullah

doi:10.1111/ijcp.12377

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…From our study, the pooled prevalence of gout was 1.1%, which is similar to that in Italy (0.9% in 2009) [ 19 ], France (0.9% in 2013) [ 72 ], the United Kingdom, and Germany (1.4% in 2000–2005) [ 17 ]. In addition, the prevalence of gout in our country was much higher than that in Turkey (0.31% in 2001-2002) [ 73 ], Mexico (0.3% in 2011) [ 74 ], Greece (0.47% in 2003) [ 75 ], and the Czech Republic (0.3% in 2002-2003) [ 76 ] but is markedly lower than that in New Zealand (2.69% in 2008-2009) [ 77 ], the USA (3.9% in 2007-2008) [ 21 ], and Australia (9.7% in 2002) [ 78 ].…”

Section: Discussionmentioning

confidence: 94%

Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis

Han

et al. 2015

BioMed Research International

477

370

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We systematically identified the prevalence of hyperuricemia and gout in mainland China and provided informative data that can be used to create appropriate local public health policies. Relevant articles from 2000 to 2014 were identified by searching 5 electronic databases: PubMed, Google Scholar, Chinese Wanfang, CNKI, and Chongqing VIP. All of the calculations were performed using the Stata 11.0 and SPSS 20.0 software. The eligible articles (n = 36; 3 in English and 33 in Chinese) included 44 studies (38 regarding hyperuricemia and 6 regarding gout). The pooled prevalence of hyperuricemia and gout was 13.3% (95% CI: 11.9%, 14.6%) and 1.1% (95% CI: 0.7%, 1.5%), respectively. Although publication bias was observed, the results did not change after a trim and fill test, indicating that that impact of this bias was likely insignificant. The prevalence of hyperuricemia and gout was high in mainland China. The subgroup analysis suggested that the geographical region, whether the residents dwell in urban or rural and coastal or inland areas, the economic level, and sex may be associated with prevalence.

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Section: Discussionmentioning

confidence: 94%

Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis

Han

et al. 2015

BioMed Research International

477

370

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“… 1 A population-based epidemiological study revealed the estimated prevalence of gout as 0.31% for subjects ≥ 20 years of age, and 0.72% for subjects ≥ 40 years of age in an urban area of Turkey. 2 The burden of gout has increased in the last decades in industrialised countries. This increased incidence is attributed to changes in lifestyle, to related comorbidities including obesity and metabolic syndrome and to prolonged lifespan.…”

Section: Introductionmentioning

confidence: 99%

Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities

Ulutaş

Bozdemir

Çelikyürek

et al. 2021

MJR

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Objective: This study aimed to determine the association between hyperuricemia, comorbid diseases and risk of developing gout disease in a Turkish population in a long follow-up period. Methods: A total of 2000 Turkish adults were cross-sectionally analysed for serum urate levels in 2009 at the Pamukkale University Faculty of Medicine. All patients on regular follow-up at our tertiary health center (n=1322) were included in this study. Demographic features (age and gender), comorbid clinical conditions, and medication use were noted. The risk of developing gout and the determinant factors were investigated. Multivariate logistic regression analysis was performed to analyse causative effects of factors while receiver operating characteristic (ROC) curve analysis was used to identify optimal cut-off values of uric acid level for predicting the development of gout. Results: Among 1322 patients, the mean age was 56.9 (SD:14.68) years. 57.3% (n=758) of the patients were female. The most common co-morbid disease was chronic kidney disease (581, 43%), followed by hypertension (522, 39.4%). Gout developed in 25 patients (1.8%). Gout development risk and presence of all the above comorbidities were significantly higher in patients with serum urate ≥7mg/dl compared with <7mg/dl. Male gender and not using urate lowering drugs were the main risk factors for developing gout disease. ROC analysis of serum uric acid levels identified a cut-off value of >7 (AUC: 0.776, sensitivity 86.96%, specificity 66.74%). Conclusion: There is still a dilemma concerning the culprit effects of both comorbidities and hyperuricemia on the risk of developing gout disease.

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“…4 In two prevalence studies conducted in Turkey, the prevalence of gout was found to be 0.02% in the Havsa region and 0.31% in the İzmir region. 5,6 Although the frequency of gout varies between societies due to genetic and cultural differences 7 , its prevalence worldwide nearly doubled between 1990 and 2010. 8 This increase may be related to changes in eating habits and increasing obesity rates.…”

Section: Introductionmentioning

confidence: 99%

Corneal Endothelial Morphology and Thickness Changes in Patients with Gout

Kösekahya¹,

Atılgan²,

Atilgan³

et al. 2019

tjo

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Objectives:To investigate corneal endothelial cell density (ECD), morphology, and central corneal thickness (CCT) in patients with gout compared with healthy subjects.Materials and Methods:Fifty eyes of 50 gout patients and 50 eyes of 50 healthy subjects without gout or any other systemic disease were included in this study. After detailed ophthalmologic examination, specular microscopy (Tomey EM-4000; Tomey Corp) measurement was performed for all participants. ECD, average cell area (ACA), coefficient of variation (CV), hexagonality ratio, and CCT values were recorded.Results:Mean ECD and hexagonality ratio were lower (p=0.004 and p=0.002) and CV, ACA, and CCT values were higher (p=0.001, p=0.007, and p=0.001) in patients with gout when compared to healthy subjects. There were significant correlations between gout disease duration and CD and hexagonality ratio (p=0.019 and p=0.043) and also between uric acid value and hexagonality ratio and CCT (p=0.044 and p=0.003).Conclusion:Altered corneal endothelial function was found in patients with gout when compared to healthy subjects and the alteration increased as gout duration and uric acid value increased.

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The prevalence of gout in an urban area of Izmir, Turkey: A population-based epidemiological study

Abstract: Our data suggest that the estimated prevalence of gout (0.31%) is lower than the previously published estimated prevalence of rheumatoid arthritis (0.36%) in the same study population (14 definite rheumatoid arthritis cases among the 2835 subjects).

Cited by 8 publications

References 48 publications

Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis

Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis

Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities

Corneal Endothelial Morphology and Thickness Changes in Patients with Gout

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