The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease

Kato, Seiichi; Nishino, Yoshikazu; Ozawa, Kyoko; Konno, Mutsuko; Maisawa, Shunichi; Toyoda, Shigeru; Tajiri, Hitoshi; Ida, Shinobu; Fujisawa, Tomotsumi; Iinuma, Kazuie

doi:10.1007/s00535-004-1381-2

Cited by 83 publications

(104 citation statements)

References 27 publications

(23 reference statements)

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“…However, H. pylori incidence in children with chronic gastritis was higher than that (25.6 %) reported in a recent study (Wong et al, 2005). The results of the present study were similar to those of a Japanese study (Kato et al, 2004).…”

Section: Resultssupporting

confidence: 91%

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Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children over a period of 10 years

Boyanova

Lazarova²,

Jelev³

et al. 2007

Journal of Medical Microbiology

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The aims of the study were to evaluate the incidence of Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children from 1996 to 2006, to analyse the performance of diagnostic tests, and to look at H. pylori density in specimens by culture. Antral specimens from children with chronic gastritis (n5513), peptic ulcers (n554) and other diseases (n591) were evaluated by direct Gram staining (DGS), in-house rapid urease test (RUT) and culture. The living environment and semi-quantitative H. pylori density were assessed in 188 and 328 children, respectively. H. pylori infection was found in children with ulcers (77.8 %), chronic gastritis (64.5 %) and other diseases (36.3 %). Half (51.4 %) of patients aged 1-5 years and 77.4 % of those aged 16-17 years were H. pylori-positive. Of all children, 328 (49.8 %) showed positive DGS, 184 (28 %) had a positive RUT, and 386 (58.7 %) were culture-positive. Unlike gastric mucus specimens, frozen biopsy specimens provided reliable diagnosis. H. heilmannii was observed in two (0.3 %) children. High H. pylori density (growth into all quadrants of plates) was found in 18 % of 328 children evaluated, involving 31 % of ulcer and 16.7 % of non-ulcer patients. H. pylori infection was more common in rural children with chronic gastritis (91.3 %) than in the remainder (66.7 %). In conclusion, H. pylori infection was common in symptomatic Bulgarian children. The infection prevalence was .77 % in patients aged 16-17 years, in children with a duodenal ulcer, and in rural patients. H. heilmannii infection was uncommon. The performance of the bacterial culture was good. The impact of H. pylori density on the clinical expression and eradication of the infection requires further evaluation. The results highlight the need for routine H. pylori diagnosis in rural children with chronic gastritis. INTRODUCTIONHelicobacter pylori infection is associated with gastroduodenal diseases in humans (Matysiak-Budnik et al., 2006). The incidence of the infection in children ranges from 10 to 80 %, and is high in developing and some other countries (Torres, 2000; Janulaityte-Gunther et al., 2005;Kato et al., 2004). H. pylori infection is most often intrafamilial and spreads by oral-oral or faecal-oral transmission (Megraud, 2003;Mladenova et al., 2006). Helicobacter heilmannii can also infect the human stomach. The incidence (usually ,1 %) of this zoonotic infection in dyspeptic patients is much lower than that caused by H. pylori (Ierardi et al., 2001;Okiyama et al., 2005). There are, however, only a few reports concerning H. heilmannii incidence in children (Coman et al., 1996;Mention et al., 1999; Sykora et al., 2004).The aims of the present study were to assess the incidence and characteristics of H. pylori and H. heilmannii infections in untreated Bulgarian children over a period of 10 years, according to age, sex, disease and living environment; to analyse the performance of diagnostic tests according to the type of antral specimen; and to evaluate H. pylori density in the biopsy spec...

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Section: Resultssupporting

confidence: 91%

“…The incidence of the infection in children ranges from 10 to 80 %, and is high in developing and some other countries (Torres, 2000; Janulaityte-Gunther et al, 2005;Kato et al, 2004). H. pylori infection is most often intrafamilial and spreads by oral-oral or faecal-oral transmission (Megraud, 2003;Mladenova et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children over a period of 10 years

Boyanova

Lazarova²,

Jelev³

et al. 2007

Journal of Medical Microbiology

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“…This can be attributed to the changing food habits and westernization in our country or due to increased diagnosis by endoscopy.A retrospective Japanese study published in 2004 concluded that H. pylori was significantly linked to duodenal ulcer and gastric ulcers in the age group of 10-16 years, but not in the age group of 9 years and under. 9 A 14 year boy with severe malnutrition who presented with acute abdomen, loose stools and right iliac fossa tenderness was diagnosed as Crohn's disease based on CT enterography and colonoscopy. He had been treated as abdominal tuberculosis in the past with multiple courses of anti-tuberculosis drugs.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of children presenting with acute abdomen in a tertiary care centre of South Tamilnadu: a retrospective observational study

Rajma

Arun

Jeyabalaji

et al. 2016

Int J Contemp Pediatr

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Background: Acute abdominal pain is a common presentation in both outpatient visits and emergency room. It can be organic or functional, medical or surgical. We did an observational study to evaluate the clinical profile of children presenting with acute abdominal pain <7 days duration and analyse the various medical and surgical causes for this clinical presentation.Methods: Children <15 years presenting with acute onset pain abdomen <7 days with or without fever, vomiting, loose stools or urinary symptoms and admitted in pediatric ward were included in the study. Out of the 205 children enrolled in the study, 120 were males and 85 were females.Results: Only 15.6% of cases were of surgical etiology requiring elective or emergency surgical interventions. Among the 173 children diagnosed with variety of medical conditions, the most common condition presenting with pain abdomen was acid peptic disease (16%) followed by acute gastro enteritis(14%) and Urolithiasis(13%). Increasing prevalence of acute pancreatitis and type 1 diabetes mellitus (13 cases each) in children were observed.Conclusions: Long term follow up of children presenting with mesenteric adenopathy without other significant pathology is warranted to avoid unnecessary empirical antituberculous treatment. Our study helped us to identify the different spectrum of etiologies across the three age groups (1-5 years, 6-10 years, 11-15 years) and some diseases were showing male or female predilection.

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“…In fact, pooled analysis of early reports (from 1983 to 1994) has demonstrated that the prevalence of H. pylori in children with duodenal ulcer was relatively higher (ranging from 33% to 100%, with a median value of 92%), compared with children with gastric ulcer (ranging from 11% to 75%, with a median value of 25%) [104]. A more recent retrospective study (from 1995 to 2001) from Japan confirmed a very high prevalence of H. pylori in antral gastritis and duodenal ulcer (98.5% and 83%, respectively), also identifying H. pylori as a risk factor for the development of gastric ulcer although with a lower prevalence of infection (less than 50%) [101]. Finally, in a Chinese study, it was reported that among 43 Chinese children suffering with peptic ulcer disease, 37 had duodenal ulcer, of which 21 were H. pylori positive, while only six had gastric ulcer, of which only two were positive for the infection [7].…”

Section: Nevertheless Specific Populations Such As Immigrants and Rumentioning

confidence: 98%

“…In a recent large European multicenter study, including 1233 symptomatic children with H. pylori infection, peptic ulcer disease was diagnosed in less than 5% of children younger than 12 years of age and in ≈10% of teenagers [8]. Interestingly, other studies indicate a higher association of H. pylori with peptic ulcer in adolescents than in younger children [100,101]. But, the prevalence of H. pylori-positive ulcers in children also differs between countries and this is not completely explained by the prevalence of the infection in the population studied.…”

Section: Prevalence Of H Pylori-associated Gastric and Duodenal Ulcementioning

confidence: 99%

Helicobacter pylori—Associated Dyspepsia in Paediatrics

Roxo-Rosa¹,

Oleastro²,

Lopes³

2013

Dyspepsia - Advances in Understanding and Management

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The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease

Cited by 83 publications

References 27 publications

Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children over a period of 10 years

Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children over a period of 10 years

Clinical profile of children presenting with acute abdomen in a tertiary care centre of South Tamilnadu: a retrospective observational study

Helicobacter pylori—Associated Dyspepsia in Paediatrics

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