The Prevalence of Helicobacter Pylori Infection in Benign Laryngeal Disorders

Rubin, John S.; Benjamin, Ernst; Prior, Alison; Lavy, Jeremy; Ratcliffe, Philippa

doi:10.1016/s0892-1997(02)00076-0

Cited by 17 publications

(28 citation statements)

References 26 publications

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“…One group detected no Helicobacter pylori -like organisms in laryngeal samples using Giemsa and haematoxylin-eosin staining28, whereas another study using similar techniques detected organisms resembling Helicobacter, although these bacteria could not be positively identified by immunohistochemistry29. In contrast Fang et al30, Rubin et al31, Borkowski et al32 and Jaspersen et al,33 all report the presence of helicobacter pylori via urease assays and histology in patients with benign laryngeal lesions or chronic laryngitis.…”

Section: The Effects Of External Challenges On Laryngeal Mucosal Immumentioning

confidence: 99%

At the crossroads: mucosal immunology of the larynx

et al. 2009

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The larynx sits at the crossroads between gastrointestinal and respiratory tracts. Besides its intrinsic importance in breathing, swallowing and voice production, the larynx is also exposed to unique immunological challenges. Given the propensity of chronic inflammatory conditions such as chronic laryngitis, which affects up to 20% of Western populations, it is perhaps surprising that our understanding of the immunology of this organ remains relatively limited. However, recent work on the immunological architecture of the laryngeal mucosa, and its changes that result from external challenges and inflammatory conditions, provided valuable insight into the fascinating immunology of this organ. The lessons learnt from these investigations may go beyond devising improved therapy for chronic laryngeal inflammation. Establishing whether and how the laryngeal mucosa may be involved in the modulation of wider mucosal responses may provide novel routes to the treatment of other inflammatory diseases of the respiratory and alimentary tracts such as asthma and inflammatory bowel disease.

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Section: The Effects Of External Challenges On Laryngeal Mucosal Immumentioning

confidence: 99%

At the crossroads: mucosal immunology of the larynx

et al. 2009

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“…There are studies suggesting a possible role of H. pylori in the LSCC, as well as denying them. There are many serological studies relating H. pylori and laryngeal disorders, but results and conclusions vary [27,28,30]. The fast urease test, immunohistochemical methods, light microscopy, and tissue cultures can also be false-positive, as well as false-negative [7,31,32].…”

Section: Discussionmentioning

confidence: 99%

Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma

Burduk

2013

Med Sci Monit

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BackgroundThe aim of the study was to evaluate the presence of cagA gene Helicobacter pylori in etiopathogenesis of initiation and development of larynx squamous cell carcinoma (LSCC) and its predictable role as a prognostic factor.Material/MethodsThe prospective, controlled study involved a series of 75 patients (65 male, 10 female, mean age 59.1 years, range 43 to 79 years) with larynx cancer. Samples of larynx cancerous tissue, each of 10–15 mg, were obtained from fresh tissues and were used for nucleic acid purification. DNA was extracted from 225 samples (larynx tumor – I (75), margin of tumor and normal tissue – II (75) and normal larynx tissue from opposite side to the tumor – III). All samples were subjected to H. pylori ureA detection by the PCR H. pylori diagnostic test. Samples that were positive for ureA H. pylori gene were evaluated for cagA H. pylori gene.ResultsPresence of H. pylori cagA gene was identified in 46,7% to 49,3% of 75 H. pylori ureA gene-positive larynx cancer depending of tissue location. There was a correlation of high incidence of positive cagA gene in larynx cancer tissue in supraglottic versus subglottic and glottic location. We observed a predominance of cagA gene in LSCC in patients with positive cervical lymph nodes and clinical stage T3 and T4.ConclusionsH. pylori is present in larynx tissue and may be a possible carcinogen or co-carcinogen in LSCC development, but that must be addressed by future investigations. The presence of cagA gene in larynx cancer tissues significantly decreases survival rate and increases the disease recurrence possibilities.

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“…HP organism can be found in colonies in dental plaque, saliva, tonsils and adenoids (4). It has been investigated in several other organ systems but has not been investigated to any major degree in laryngeal disorders, a region that could be directly exposed to the bacterium from pharyngolaryngeal reflux (11). Borkowski and others detected HP bacterium in 17.1% of patients with chronic hoarseness, as they found that six of their patients that investigated (17.1%) revealed a positive urease test (12).…”

Section: Discussionmentioning

confidence: 99%