The prevalence of <i>Helicobacter pylori</i> infection in malignant and premalignant conditions of the head and neck

Rubin, John S.; Benjamin, Ernst; Prior, Alison; Lavy, Jeremy

doi:10.1258/002221503762624558

Cited by 37 publications

(30 citation statements)

References 22 publications

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“…pylori infection is more common in developing countries. Apart from being a major etiological agent in chronic gastritis, peptic ulcer disease, and various gastric malignancies [6,7], an association between H. pylori and certain extra-gastric manifestations such as haematological disorders, cardiovascular and respiratory disorders, neurological disorders, diabetes mellitus, ear and eyes diseases, and head and neck malignancies has also been noted [8,9]. It has also been identified in human dental plaques, saliva, in oral lesions and ulcers, and in adenotonsillar tissue [10,11].…”

Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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To detect the presence of Helicobacter pylori in nasal polyps. A case-control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen's stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori.H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps.

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Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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“…Relation between H. pylori and laryngeal disorders is a question that it is still needed to be answered through many investigations and wide studies. Serological tests vary in their results [25,26], urease test, light microscopy and immunohistochemical methods can give false positive and false negative results, so they cannot depend on for real evaluation [27]. These data were proved by the results of a case control study performed by Genc et al [28 using the serological methods and immunohistochemical staining only and could not find a statistical significance between the benign laryngeal polyps and the LSCC with negative histochemical slides.…”

Section: Discussionmentioning

confidence: 99%

UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study

Barakat

Nabiel

Ali

et al. 2016

Eur Arch Otorhinolaryngol

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This work aims to estimate the prevalence of Helicobacter pylori ureA gene and evaluate cagA gene-positive strains in both patients of laryngeal squamous cell carcinoma (LSCC) and those with benign laryngeal polyps. This study included 49 patients confirmed pathologically to have LSCC and 15 patients with benign laryngeal polyps over a period from June 2013 to March 2015. Samples of laryngeal tissue were collected during direct laryngoscope under general anesthesia to be pathologically evaluated followed by analysis for H. pylori detection. Each laryngeal tissue sample was divided into three parts; one for bacteriological examination, the second for pathological examination and the third for PCR to detect both ureA and cagA genes. Out of 49 LSCC samples, 31 (64.6 %) was positive for ureA by PCR. Out of them, 29 samples (93.5 %) were cagA positive. Only three cases (20 %) of the benign laryngeal polyp were ureA positive by PCR and one of them was cagA positive by PCR. By the bacteriological culture, only eight samples (25.8 %) gave growth. All of them were ureA positive and only seven of them were cagA positive. There was a significant association between presence of H. pylori and LSCC as compared to benign laryngeal polyp which may contribute in the pathogenesis of laryngeal carcinoma. These results should be confirmed by further studies over larger number of cases.

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“…There are studies suggesting a possible role of H. pylori in the LSCC, as well as denying them. There are many serological studies relating H. pylori and laryngeal disorders, but results and conclusions vary [27,28,30]. The fast urease test, immunohistochemical methods, light microscopy, and tissue cultures can also be false-positive, as well as false-negative [7,31,32].…”

Section: Discussionmentioning

confidence: 99%

Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma

Burduk

2013

Med Sci Monit

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BackgroundThe aim of the study was to evaluate the presence of cagA gene Helicobacter pylori in etiopathogenesis of initiation and development of larynx squamous cell carcinoma (LSCC) and its predictable role as a prognostic factor.Material/MethodsThe prospective, controlled study involved a series of 75 patients (65 male, 10 female, mean age 59.1 years, range 43 to 79 years) with larynx cancer. Samples of larynx cancerous tissue, each of 10–15 mg, were obtained from fresh tissues and were used for nucleic acid purification. DNA was extracted from 225 samples (larynx tumor – I (75), margin of tumor and normal tissue – II (75) and normal larynx tissue from opposite side to the tumor – III). All samples were subjected to H. pylori ureA detection by the PCR H. pylori diagnostic test. Samples that were positive for ureA H. pylori gene were evaluated for cagA H. pylori gene.ResultsPresence of H. pylori cagA gene was identified in 46,7% to 49,3% of 75 H. pylori ureA gene-positive larynx cancer depending of tissue location. There was a correlation of high incidence of positive cagA gene in larynx cancer tissue in supraglottic versus subglottic and glottic location. We observed a predominance of cagA gene in LSCC in patients with positive cervical lymph nodes and clinical stage T3 and T4.ConclusionsH. pylori is present in larynx tissue and may be a possible carcinogen or co-carcinogen in LSCC development, but that must be addressed by future investigations. The presence of cagA gene in larynx cancer tissues significantly decreases survival rate and increases the disease recurrence possibilities.

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The prevalence of Helicobacter pylori infection in malignant and premalignant conditions of the head and neck

Cited by 37 publications

References 22 publications

Detection of Helicobacter pylori in Nasal Polyps

Detection of Helicobacter pylori in Nasal Polyps

UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study

Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma

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