The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

Atçı, İbrahim Burak; Yılmaz, Hakan; Samancı, Yavuz; Atçi, Aysel Gürcan; Karagöz, Yeşim

doi:10.31616/asj.2018.0333

Cited by 8 publications

(12 citation statements)

References 32 publications

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“…Most studies used the center of the intervertebral disc 10,21,[27][28][29][30]39,43,45,50,52,53,56,[59][60][61][62]65,71,74,79 or the superior/inferior endplate 9,15,19,20,26,31,34,35,41,44,[47][48][49]57,63,64,66,[68][69][70]82,83,85 as the level of slice. These slices are common and available in clinical practice.…”

Section: Slice Selectionmentioning

confidence: 99%

“…Visual Semiquantitative Parameters Our review showed that several early studies used semiquantitative visual grading with distinct cut-off points (2-point scale 19,67 , 19,67 , 3-point scale 9,16,49,64,68,78 , 4-point scale 7,15,18,29,34,37,48,50,59,80 , and 5-point scale 17,28,35,51 ). When muscles were graded, the interobserver and intraobserver agreements were both acceptable with or without cut-off points 7,34,51 .…”

Section: Imaging Parametersmentioning

confidence: 99%

“…Most studies 9–74 used conventional MRI for measuring FI. In the field of MRI sequence, our results showed that T2‐weighted images 10,12–14,17,18,20,24,25,27,29,30,32–35,37,39–53,55,56,58–63,65,66,69,70 were used in quantitative assessments more often. It is expedient for orthopaedists to evaluate FI on frequently‐used T2‐weighted images.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Studies that investigated nonspecific LBP were inclined to assess multiple segments in the lower lumbar region 21,23,24,26,28,34–36,48,49,52,54,55,57,60–65,83 , especially focusing on L4. According to Crawford et al 87 ,.…”

Section: Literature Reviewmentioning

confidence: 99%

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Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Han

Jiang

Zhang

et al. 2021

Orthopaedic Surgery

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Purpose: Numerous studies have applied a variety of methods to assess paraspinal muscle degeneration. However, the methodological differences in imaging evaluation may lead to imprecise or inconsistent results. This article aimed to provide a pragmatic summary review of the current imaging modalities, measurement protocols, and imaging parameters in the evaluation of paraspinal muscle fat infiltration (FI) in MRI studies.Methods: Web of Science, EMBASE, and PubMed were searched from January 2005 to March 2020 to identify studies that examined the FI of paraspinal muscles on MRI among patients with lumbar degenerative diseases.Results: Intramyocellular lipids measured by magnetic resonance spectroscopy and FI measured by chemical-shift MRI were both correlated to low back pain and several degenerative lumbar diseases, whereas results on the relationship between FI and degenerative lumbar pathologies using conventional MRI were conflicting. Multi-segment measurement of FI at the lesion segment and adjacent segments could be a prognostic indicator for lumbar surgery. Most studies adopted the center of the intervertebral disc or endplate as the level of slice to evaluate the FI. Compared with visual semiquantitative assessment, quantitative parameters appeared to be precise for eliminating individual or modality differences. It has been demonstrated that fat CSA/total CSA (based on area) and muscle-fat index (based on signal intensity) as quantitative FI parameters are associated with multiple lumbar diseases and clinical outcomes after surgery. Conclusion:Having a good command of the methodology of paraspinal muscle FI on MRI was effective for diagnosis and prognosis in clinical practice.

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Section: Slice Selectionmentioning

confidence: 99%

Section: Imaging Parametersmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Han

Jiang

Zhang

et al. 2021

Orthopaedic Surgery

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“…Це виникає через структурні зміни в м'язі, які не зникають після припинення болю, а продовжують існувати, призводячи до рецидиву. Накопичення жиру в м'язах на рівні L IV -L V пов'язують не лише з болем, а й з порушенням структури замикальної пластинки (Modic I та I/ II типа) [21]. Крім того, вираженість порушень у міжхребцевому диску асоційована зі змінами в замикальній пластинці та накопиченням жиру в паравертебральних м'язах як жінок, так і чоловіків у віці понад 50 років із болем у попереку [14].…”

Section: больовий синдромunclassified

Relationship between structural changes in paravertebral muscles and the development of spine degenerative diseases

Radchenko¹,

Ashukina²,

Maltseva³

et al. 2021

OTP

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Based on the systematic approach to the diagnosis of spinal pathology, there are no fundamental differences in the etiology of spine degenerative disease, facet joints arthritis, and other diseases. These diseases are considered multifactorial: age (aging), systemic regulatory factors (hormones, peptides, cytokines), genetic predisposition, inadequate physical activity, unfavorable environmental factors, and others lead to pathological changes in the structure of the spinal motor segment components. Recently, much attention has been paid to the paravertebral muscles changes, in which over time, as a result of injuries or degenerative processes, inevitably lead to dysfunction, which can lead to the occurrence of chronic lumbar pain. Objective. To assess the relationship between structural changes in paravertebral muscles and the development of degenerative diseases of the spine on the basis of scientific literature review. It was found that degenerative changes in paravertebral muscles, as components of spinal motor segments, develop with aging. In particular, muscle fibers are replaced by fat tissue, which is more pronounced in women compared to men. A direct correlation between chronic lumbar pain and paravertebral muscle atrophy has been reported. Systemic factors, in particular low levels of vitamin D, also can cause the development of degenerative changes in paravertebral muscles, especially in women. Obesity provokes systemic inflammation, increases fatty infiltration of skeletal muscles and increases sensitivity to pain. Reduced levels of physical activity lead to weakness and atrophy of the paravertebral muscles, which can cause degeneration of the intervertebral disc. At the same time, exercise prior to spinal surgery for degenerative diseases improves functional outcomes and reduces pain. Conversely, damage to the paravertebral muscles increase the load on the adjacent to spinal fusion segments. In general, the role of paravertebral muscles in the development of degenerative spinal diseases has not been definitively studied.

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Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

Cooley

Jensen

Kjær

et al. 2022

Sci Rep

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Associations between multifidus muscle morphology and degenerative pathologies have been implied in patients with non-specific low back pain, but it is unknown how these are influenced by pathology severity, number, or distribution. MRI measures of pure multifidus muscle cross-sectional area (CSA) were acquired from 522 patients presenting with low back and/or leg symptoms in an outpatient clinic. We explored cross-sectional associations between the presence, distribution, and/or severity of lumbar degenerative pathologies (individually and in aggregate) and muscle outcomes in multivariable analyses (beta coefficients [95% CI]). We identified associations between lower pure multifidus muscle CSA and disc degeneration (at two or more levels): − 4.51 [− 6.72; − 2.3], Modic 2 changes: − 4.06 [− 6.09; − 2.04], endplate defects: − 2.74 [− 4.58; − 0.91], facet arthrosis: − 4.02 [− 6.26; − 1.78], disc herniations: − 3.66 [− 5.8; − 1.52], and when > 5 pathologies were present: − 6.77 [− 9.76; − 3.77], with the last supporting a potential dose–response relationship between number of spinal pathologies and multifidus morphology. Our findings could hypothetically indicate that these spinal and muscle findings: (1) are part of the same degenerative process, (2) result from prior injury or other common antecedent events, or (3) have a directional relationship. Future longitudinal studies are needed to further examine the complex nature of these relationships.

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The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

Cited by 8 publications

References 32 publications

Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Imaging Evaluation of Fat Infiltration in Paraspinal Muscles on MRI: A Systematic Review with a Focus on Methodology

Relationship between structural changes in paravertebral muscles and the development of spine degenerative diseases

Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

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