The prevalence of melasma and its association with quality of life in adult male Latino migrant workers

Pichardo, Rita O; Vallejos, Quirina M.; Feldman, Steven R.; Schulz, Mark R.; Verma, Amit Kumar; Quandt, Sara A.; Arcury, Thomas A.

doi:10.1111/j.1365-4632.2009.03778.x

Cited by 97 publications

(105 citation statements)

References 28 publications

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“…10,16 these findings are in accordance with the study conducted by Ali et al 10 where the results were if the patients had melasma for a longer duration of time they had a poorer QoL. The mean duration of melasma in our study was 3 years +6 months.…”

Section: Discussionsupporting

confidence: 83%

Melasma; Quality of Life in Patients

Luqman

2017

TPMJ

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, Sultana Jam 5 ABSTRACT… Introduction: Melasma is an acquired, chronic, recurrent symmetrical hypermelanosis which is characterized by brown patches of variable darkness on sun exposed areas of the body primarily on the face.1,2 Melasma is more common in Asians and in people who live in locations that receive high intensity UV radiation. 3,4 Melasma is a skin disease that significantly affects social and emotional wellbeing of the patients as well as their Quality of Life (QoL). Objectives: To find out the impact of melasmaon quality of life of the patients. Study Design: It is a descriptive study and the sample (patients), were selected through convenient sampling. Place and Duration of study: The study was conducted in the department of psychiatry & Dermatology department of Bahawal Vicortoria Hospital, Bahawalpur from July to December 2016. Material and Methods: Hundred patients having melasma including 11 males and 89 females from both departments were included in the study. Two questionnaires were applied for measuring target variables, these were (i) Dermatology Life Quality Index to assess the effect of melasma on quality of life (DLQI) and (ii) Melasma Area Severity Index (MASI) to determine the severity of melasma. Results: The study included 100 patients of which 89 were females while 11 were males. Mean age of the patients was 27+6. Regarding the educational status of patients, the majority (36%) were graduates and 16% had a Masters degree. Of these patients, 53% were unmarried while 47% were married. Mean DLQI was slightly higher for female patients (13.48) as compared to male patients (12.82). Mean MASI was also higher in females (15.26) as compared to males which was (14.39). Conclusions: Melasma causes significant negative impact on quality of life especially in women.

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Section: Discussionsupporting

confidence: 83%

Melasma; Quality of Life in Patients

Luqman

2017

TPMJ

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“…[1,2] The exact prevalence of melasma in India is not known,however, it is observed more frequently among individuals with skin type IV-VI, especially in women of Hispanic, Carribean and Asian origin living in areas of intense ultraviolet radiation [3]. Melasma is commoner in women, especially in their reproductive years, but about 10% cases occur in men also.…”

Section: *Correspondencementioning

confidence: 99%

Serum Iron profile in Female patients of Melasma-A case control study

Qazi¹,

Dogra²,

Dogra³

2017

APJHS

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Background: Melasma is a common acquired pigmentary dermatosis characterized by presence of symmetric, hyperpigmented patches, most commonly seen on the face. It is most commonly seen in young to middle aged females. The exact cause of melasma is not known, however a number of factors have been implicated in its etiopathogenesis. The effect of body iron stores on melasma is not exactly known. Although iron overload has been seen to affect skin pigmentation, effect of low body iron stores on skin pigmentation is unknown. In this study, we evaluated total body iron stores by assessing serum iron , ferritin and total iron binding capacity (TIBC) level among nonpregnant females with and without melasma. Materials and Methods: A cross-sectional case control study was conducted in 2016 at Department of Dermatology, Government Medical College, Jammu for a period of one year. The study comprised of 70 non pregnant females with and without melasma . Serum iron level, TIBC and ferritin in the two groups were measured and compared. The severity of melasma was assessed on the basis of MASI score. The correlation between severity of melasma and derangements in iron profile were also assessed in the study. Results: Comparison of serum Iron levels in cases and controls showed lower levels in patients of melasma(58.84± 29.17) as compared to control population (82.26± 45.83) ;p<0.001. Serum ferritin levels were found to be lower in patients of melasma (20.06±18.64) as compared tp control population(42.29±30.08);p<0.001.Comparison of serum TIBC between cases and controls showed higher values in cases(424±58 98.33) compared to control population (384.45± 74.55) p<0.007.Also a positive correlation was found between severity of melasma as per MASI score and derangement in Iron profile. Conclusion: Serum Iron, ferritin levels were found to be significantly lower in patients of melasma compared to the control population whereas Total iron binding capacity(TIBC) was found to be higher in patients of melasma compared to the control population indicating low body iron storesin patients of melasma. The severity of maelasma as per MASI score correlated well with the derangements in iron profile. Hence patients with melasma had low body Iron stores compared to control population indicating a possible role of iron deficiency in the etiopathogenesis of melasma.

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“…In vivo reflectance confocal imaging of murine skin following exposure to UVB light highlighted its effect on the dendricity of melanocytes (8). Furthermore, UV light exposure along with genetic factors was found to be a strong predictor for the development of melasma (9,10), a condition in which epidermal melanocytes within lesions exhibit higher levels of melanin and more dendrites than melanocytes in adjacent normal skin (11).…”

mentioning

confidence: 99%

MicroRNA 340 Is Involved in UVB-Induced Dendrite Formation through the Regulation of RhoA Expression in Melanocytes

Jin

Zhu

et al. 2014

Molecular and Cellular Biology

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The influence of UV irradiation on pigmentation is well established, but the molecular and cellular mechanisms controlling dendrite formation remain incompletely understood. MicroRNAs (miRNAs) are a class of small RNAs that participate in various cellular processes by suppressing the expression of target mRNAs. In this study, we investigated the expression of miRNAs in response to UVB irradiation using a microarray screen and then identified potential mRNA targets for differentially expressed miRNAs among the genes governing dendrite formation. We subsequently determined the ability of miRNA 340 (miR-340) to suppress the expression of RhoA, which is a predicted miR-340 target gene that regulates dendrite formation. The overexpression of miR-340 promoted dendrite formation and melanosome transport, and the downregulation of miR-340 inhibited UVBinduced dendrite formation and melanosome transport. Moreover, a luciferase reporter assay demonstrated direct targeting of RhoA by miR-340 in the immortalized human melanocyte cell line Pig1. In conclusion, this study has established an miRNA associated with UVB irradiation. The significant downregulation of RhoA protein and mRNA expression after UVB irradiation and the modulation of miR-340 expression suggest a key role for miR-340 in regulating UVB-induced dendrite formation and melanosome transport. Melanocytes originate from neural crest-derived melanoblasts, which migrate and differentiate in the basal layer of the epidermis (1). A hallmark of melanocytes is their ability to form dendrites, which are specialized cell structures that transport melanosomes to their tips for transfer to the surrounding keratinocytes in response to growth factors and UV irradiation. Following skin penetration by UV rays and subsequent DNA damage, thymidine dinucleotide fragments induce melanogenesis and cause the melanocyte to produce melanosomes (2).These melanosomes are then transferred to neighboring keratinocytes through the intricate network of melanocyte dendrites, contributing to skin darkening and thereby providing protection from UV radiation (3, 4). Melanocyte dendrites can vary markedly in length and number in response to different growth factors and, in a manner analogous to the way in which neural cells seek out target neurons, these dendrites form growth cone-like structures that attach to keratinocytes. Melanocyte-keratinocyte adhesion is a prerequisite for the transfer of melanosomes to keratinocytes; therefore, the formation of melanocyte dendrites, particularly of the appropriate length and number, is essential for efficient melanosome transfer. Due to the importance of dendricity for melanocyte activity, cutaneous pigmentation, and photoprotection, it is critical to determine the precise mechanisms involved in the regulation of melanocyte dendrite formation.It is well known that melanocytes are sensitive to UV irradiation, with substantial evidence suggesting that it plays a pivotal role in regulating melanocyte dendricity. Studies have shown that UV irradiation induce...

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The prevalence of melasma and its association with quality of life in adult male Latino migrant workers

Abstract: Background-Melasma is a common condition of Latina women that detracts from their quality of life. The prevalence and impact of melasma in Latino men is not well characterized.

Cited by 97 publications

References 28 publications

Melasma; Quality of Life in Patients

Melasma; Quality of Life in Patients

Serum Iron profile in Female patients of Melasma-A case control study

MicroRNA 340 Is Involved in UVB-Induced Dendrite Formation through the Regulation of RhoA Expression in Melanocytes

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