The prevalence of metabolic syndrome in patients with bipolar disorder

García-Portilla, María Paz; Sáiz, Pilar A.; Benabarre, Antonio; Sierra, Pilar; Perez, Josefina; Rodriguez, Alfonso; Livianos, Lorenzo; Torres, Pedro Iturralde; Bobes, Julio

doi:10.1016/j.jad.2007.06.002

Cited by 100 publications

(78 citation statements)

References 15 publications

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“…Figure 1 presents the clinical comorbidities exhibited by studied patients, where the most commonly observed ones were: hypertension (50%), obesity (46.4%), hypothyroidism (39.3%), and gastric problems (32.1%). It is known that bipolar patients are more susceptible to clinical comorbidities (Angst et al, 2000) and many of these could be due to utilized medications, such as hypothyroidism (Bocchetta et al, 2007) and obesity (Ketter, Haupt, 2006;Garcia-Portilla et al, 2008). It is also known that lithium and valproate could lead to hypothyroidism, and that mood stabilizers and antipsychotics could lead to obesity.…”

Section: Resultsmentioning

confidence: 99%

Pilot-project of implantation of pharmaceutical care close to the program of bipolar mood disorder of the Hospital of Clinics of Porto Alegre

Ceresér¹,

Mascarenhas²,

Santin³

et al. 2009

Braz. J. Pharm. Sci.

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The Bipolar Mood Disorder is characterized by the alternation of depressive crises with episodes of mania or euphoria, having these patients 15 to 35 times more chances of suicide, as compared with people without this disorder. The pharmacotherapy is fundamental for this disease, aiming to decrease the frequency of episodes and disease severity. In these patients, the polypharmacy has recently increased and one of the main difficulties is the adherence to treatment. The objective of this study was to contribute for the improvement of bipolar patients health conditions, developing their respective pharmacotherapeutic follow-up. Twenty eight adult bipolar patients who were participants of a specialized clinic within a tertiary hospital in Porto Alegre have been randomly selected, and the Dader Method of pharmacotherapeutic follow-up has been applied. The more common clinical comorbidities were: hypertension (50%), obesity (46.43%), and hypothyroidism (36.29%). The bipolar patients are more susceptible to clinical comorbidities, and many of them could be due to pharmacotherapy. Only 1.43% of patients presented Drug Related Problems, being all of them resolved along the study. It was also observed that 32.14% of evaluated patients presented low adherence to treatment, and between these patients, 55.56% passed to have good adherence after pharmacotherapeutic follow-up. The pharmacotherapeutic follow-up is fundamental for the improvement of patient's health. New studies, with higher number of patients and longer duration, are necessary to evaluate the percentage of patients that could be beneficiary of Pharmaceutical Care.
O Transtorno do Humor Bipolar é caracterizando pela alternância de crises depressivas com episódios de mania ou euforia, tendo estes pacientes 15-35 vezes mais chances de suicídio em comparação com pessoas sem este transtorno. A farmacoterapia é fundamental, visando diminuir a freqüência dos episódios e a gravidade da doença. Nestes pacientes, a polifarmácia tem aumentado ultimamente e uma das maiores dificuldades é a adesão ao tratamento. O objetivo do estudo foi contribuir para a melhoria das condições de saúde de pacientes bipolares, realizando o acompanhamento farmacoterapêutico dos mesmos. Foram selecionados aleatoriamente 28 pacientes bipolares adultos, participantes de um ambulatório especializado de um hospital terciário em Porto Alegre e aplicado o Método Dáder de acompanhamento farmacoterapêutico. As co-morbidades clínicas mais comuns foram: hipertensão (50%), obesidade (46,43%) e hipotiroidismo (39,29%). Os pacientes bipolares são mais suscetíveis a co-morbidades clínicas e muitas destas podem ser devidas a farmacoterapia. Apenas 1,43% dos pacientes apresentavam Problemas Relacionados a Medicamentos, sendo todos solucionados no decorrer do estudo. Também se observou que 32,14% dos pacientes avaliados apresentavam baixa adesão ao tratamento e entre estes, 55,56% passaram a ter boa adesão após o acompanhamento farmacoterapêutico. É fundamental para a melhoria da saúde do paciente o acompa...

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Section: Resultsmentioning

confidence: 99%

Pilot-project of implantation of pharmaceutical care close to the program of bipolar mood disorder of the Hospital of Clinics of Porto Alegre

Ceresér¹,

Mascarenhas²,

Santin³

et al. 2009

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…Our findings are consistent with previous studies where prevalence rates of hypertension in patients with bipolar affective disorder range between 18-39%. [37][38][39][40][41] Although the study sample is modest in size, leading to the possibility that it lacked statistical power, the sample audited nevertheless represents all consecutive inpatient admissions with bipolar affective disorder over a 12-month period to this psychiatric unit that covers a population of over 200 000. It is representative of that unit's operational practice and should be generalisable to similarly sized units.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure monitoring in psychiatric inpatients with bipolar affective disorder

Kelbrick¹,

Abdaldayim²

2014

Prog Neurol Psychiatry

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People with bipolar affective disorder are at increased risk of hypertension, but cardiovascular health screening practices in mental health services are inconsistent and often sub‐optimal. Here, the authors describe their audit to identify adults with bipolar affective disorder and comorbid hypertension in an acute psychiatric inpatient unit, and to establish the unit's level of compliance with local and national guidelines with regard to blood pressure monitoring.

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“…Considerando el impacto potencial del síndrome metabólico y sus componentes en la morbi-mortalidad de nuestros pacientes, hay una gran necesidad de implantación de programas de psicoeducación que incluyan hábitos alimenticios y de vida saludables para los pacientes con enfermedad mental grave y estos programas deberían ser capaces de una temprana detección de dichos problemas con el fin de iniciar un tratamiento adecuado 140 . Para esto es necesaria la coordinación de diferentes dispositivos asistenciales, tanto de atención especializada como de atención primaria, intentando realizar así un abordaje integral del paciente con enfermedad mental.…”

Section: La Sociedad Española De Psiquiatría (Sep) Y La Sociedad Espaunclassified

Factores determinantes del riesgo metabólico en el tratamiento con antipsicóticos atípicos

Pato¹,

Rodríguez²,

Valverde³

2016

Psiquiatría Biológica

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Desde hace años se ha constatado que la esquizofrenia y otros trastornos psicóticos se asocian a elevadas tasas de morbimortalidad. Las causas de este incremento van desde las asociadas al uso de tratamientos específicos para esta enfermedad como a factores de salud relacionados con dicho proceso.Las principales causas de muerte en personas con enfermedad mental grave son similares a las observadas en la población general. Así, en la población general, la enfermedad cardiovascular es la principal causa de mortalidad y dicha mortalidad se ha reducido en los últimos años debido a las mejoras tratamientos y a las iniciativas de salud pública. Sin embargo, la enfermedad cardiovascular aún es alta en personas con enfermedad mental grave y en ellas no se ha visto esta reducción 1 .Los pacientes con esquizofrenia tienen una esperanza de vida un 20% menor que la población general, calculándose que mueren una media de 25 años antes 2 . Se calcula un riesgo relativo de 7,5 veces superior a la población general para la mortalidad por causas no naturales, como suicidio o muerte accidental (40% de las muertes prematuras en estos pacientes); y de 2,41 veces para la mortalidad por causas naturales, especialmente enfermedades cardiovasculares, infecciosas, respiratorias, y endocrinas 3 (60% de las muertes prematuras en estos pacientes) calculándose una mortalidad general 2-3 veces superior que en la población general 4 .En estudios que abordan específicamente las causas de muerte en la esquizofrenia frente a la población general establecen las siguientes cifras: un riesgo 2,7 veces mayor en la diabetes, un riesgo 2,3 veces mayor para enfermedades cardiovasculares, un riesgo de 3,2 veces mayor para las enfermedades respiratorias y de un 3,4 para enfermedades infecciosas 5 .En general, la mayor mortalidad cardiovascular asociada a la esquizofrenia, la depresión unipolar y el trastorno bipolar se atribuye a un riesgo relativo a presentar factores de riesgo modificables de enfermedad cardiovascular de 1 a 5 veces superior al del resto de la población 6 , tal y como se aprecia en la tabla 1.

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The prevalence of metabolic syndrome in patients with bipolar disorder

Cited by 100 publications

References 15 publications

Pilot-project of implantation of pharmaceutical care close to the program of bipolar mood disorder of the Hospital of Clinics of Porto Alegre

Pilot-project of implantation of pharmaceutical care close to the program of bipolar mood disorder of the Hospital of Clinics of Porto Alegre

Blood pressure monitoring in psychiatric inpatients with bipolar affective disorder

Factores determinantes del riesgo metabólico en el tratamiento con antipsicóticos atípicos

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