The Prevalence of Metabolic Syndrome Among US Women of Childbearing Age

Ramos, Rosemarie G.; Olden, Kenneth

doi:10.2105/ajph.2007.120055

Cited by 77 publications

(49 citation statements)

References 37 publications

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“…Estimations of the overall prevalence of the metabolic syndrome have demonstrated that rates are comparable between whites, blacks, and Mexican Americans, but when the data are analyzed by gender, some racial disparities become evident. Specifically, black, Hispanic and Mexican American women are more likely to meet the criteria for the metabolic syndrome than white women [38][39][40][41]. Due to the high rate of CV disease-related mortality among patients with the metabolic syndrome [42], treatments for OA that have CV side effects may not be appropriate for use in these patient populations.…”

Section: Racial and Ethnic Disparities In Risk Factors For Nsaid Toximentioning

confidence: 99%

The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective

Balmaceda

2015

Postgraduate Medicine

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Many individuals with osteoarthritis (OA) also have other chronic, comorbid conditions, such as obesity, hypertension and diabetes, which can compound the risk for developing cardiovascular adverse events that have been associated with specific analgesics, most notably nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitor NSAIDs. Pharmacotherapy may be further complicated by genetic factors that may influence drug metabolism in certain individuals. These risks may vary according to race and ethnicity. Black and Hispanic populations are known to have a higher prevalence of cardiovascular risk factors and disease, and a substantial proportion of black and Hispanic individuals possess genotypes of the cytochrome P450 (CYP) 2C9 enzyme involved in the metabolism of many NSAIDs and the CYP2D6 enzyme involved in metabolism of the dual opioid agonist/norepinephrine-serotonin reuptake inhibitor tramadol. As a result, the efficacy and safety of available analgesics may vary between patients in different racial and ethnic groups. This review article focuses on racial and ethnic differences in cardiovascular risk and genetic factors altering drug efficacy and safety and evaluates the pharmacologic options that can be used for the management of OA in these populations. Particular emphasis is given to the place of topical NSAIDs and capsaicin in the management of OA patients for whom systemic exposure to available pharmacotherapy poses particular risk. Evidence-based guidelines in OA management, as they relate to appropriate patient-specific pharmacotherapy, are also examined.

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Section: Racial and Ethnic Disparities In Risk Factors For Nsaid Toximentioning

confidence: 99%

The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective

Balmaceda

2015

Postgraduate Medicine

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“…However, casting gestational diabetes merely as a pregnancy associated complication that mostly resolves after delivery [6,7], is inappropriate in an era where the prevalence of the metabolic syndrome and diabetes itself is increasing in all demographics, including that of women of childbearing age [8,9]. Reflecting this trend, the Standards of Medical Care in Diabetes 2012 not only calls for women with risk factors to be screened for undiagnosed type 2 diabetes at the first prenatal visit, but also defines gestational diabetes as 'diabetes diagnosed during pregnancy that is not clearly overt diabetes [10]; this represents additional precision in the definition of GDM, which as recently as 2009 was defined simply as 'diabetes diagnosed during pregnancy [6].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, in one report only 34% to 74% of women with a history of GDM received the recommended postpartum glucose screening [14]. These missed glucose screening opportunities and lack of effective intervention may be associated with the marked increase seen in the incidence of T2D among women of childbearing age [8,9]. For this cohort of women, pregnancy may represent the first time that they undergo screening for diabetes.…”

Section: Introductionmentioning

confidence: 99%

Window of Opportunity: Postpartum Screening of Women with Gestational Diabetes for Early Detection of Prediabetes and Type 2 Diabetes

Henderson

Kavookjian

Leitstein

et al. 2012

TODIAJ

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Gestational diabetes is a condition characterized by glucose intolerance during pregnancy, with defined approaches for screening, treatment, and follow-up. It is associated with a variety of adverse birth outcomes, including excessive fetal weight gain and related increases in the rate of cesarean delivery and perinatal injury as well as increased risk for developing type 2 diabetes for women who have had gestational diabetes. A diagnosis of gestational diabetes may also be a manifestation of pre-existing type 2 diabetes. Nonetheless, a substantial proportion of women with a history of gestational diabetes fail to receive the recommended postpartum glucose screening. This failure to conduct follow-up screening of women with gestational diabetes after delivery represents a missed opportunity for earlier diagnosis of diabetes, and chance to increase the awareness of women of their future risk for developing diabetes. This paper explores the barriers contributing to the lack in follow-up screening and makes recommendations about addressing these problems.

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“…There is also a need for studies to determine whether physical activity recommendations developed from primarily white, male individuals are appropriate for other populations who are at increased risk for chronic disease. We chose to study Hispanic women because of the higher prevalence of central obesity (St-Onge, Janssen, & Heymsfield, 2004), hyperinsulinaemia (Haffner et al, 1990;Ho, Davy, Hickey, Summers, & Melby, 2002), dyslipidaemia (Ramos & Olden, 2008), and increased risk for metabolic syndrome (Ford, Giles, & Mokdad, 2004;Ramos & Olden, 2008) and type 2 diabetes (Stern, Gaskill, Hazuda, Gardner, & Haffner, 1983) relative to non-Hispanic white and non-Hispanic black women of similar age. The main aim of the present study was to compare CVD risk factors in a sample of Hispanic women who meet current guidelines for physical activity against those who do not meet current guidelines using an objective measure of physical activity.…”

Section: Introductionmentioning

confidence: 99%

Physical activity recommendations and cardiovascular disease risk factors in young Hispanic women

Vella

Ontiveros

Zubia

et al. 2011

Journal of Sports Sciences

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Despite the benefits associated with regular physical activity, there is little epidemiological evidence to support positive health outcomes when meeting physical activity guidelines in high-risk ethnic groups, such as Hispanic women. We compared cardiovascular disease risk factors between young Hispanic women who meet and those who do not meet current physical activity guidelines. Height, weight, waist circumference, and blood pressure were measured in 60 Hispanic women aged 20-39 years. Lipids, C-reactive protein, insulin, and glucose were assessed. Body composition and cardiovascular fitness were assessed by BodPod and maximal oxygen uptake (VO₂(max)) respectively. Participants wore an accelerometer and average minutes (assessed in 10-min bouts) spent in light, moderate, and hard daily activity for weekdays and weekends was determined. Seventy percent of participants did not meet the recommended physical activity guidelines, whereas 30% did so. Following current physical activity guidelines was associated with significantly lower mean cholesterol (mean ± s: 4.2 ± 0.8 vs. 4.7 ± 0.9 mmol · l⁻¹) and triglycerides (0.7 ± 0.3 vs. 1.1 ± 0.6 mmol · l⁻¹), and higher fat-free mass (43.3 ± 3.8 vs. 40.2 ± 5.1 kg) and relative (40.4 ± 7.6 vs. 35.6 ± 7.0 ml · kg⁻¹ · min⁻¹) and absolute (2.5 ± 0.3 vs. 2.1 ± 0.4 litres · min⁻¹) VO₂(max) (P < 0.05). These findings suggest an improved health status in women who meet versus those who did not meet current physical activity guidelines.

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The Prevalence of Metabolic Syndrome Among US Women of Childbearing Age

Abstract: The current trends of metabolic syndrome among women of childbearing age demonstrate the need for additional rigorous investigations regarding its long-term effects in these women and their offspring.

Cited by 77 publications

References 37 publications

The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective

The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective

Window of Opportunity: Postpartum Screening of Women with Gestational Diabetes for Early Detection of Prediabetes and Type 2 Diabetes

Physical activity recommendations and cardiovascular disease risk factors in young Hispanic women

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