The prevalence of metabolic syndrome in patients with hidradenitis suppurativa

Gold, Daniel; Reeder, Virginia J.; Mahan, Meredith; Hamzavi, Iltefat

doi:10.1016/j.jaad.2013.11.014

Cited by 166 publications

(146 citation statements)

References 28 publications

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“…Literature is constantly enriched by surveys showing the complex yet established link between the metabolic syndrome and HS [63,64,65,66,67]. Consequently, comorbidities and metabolic alterations associated with HS include overweight, obesity, diabetes, insulin resistance, glucose intolerance, hyperlipidemia [64,65,66,68,69,70], as well as dysregulated adipokine levels [32,71], which may all be possible modulators of disease activity (e.g., obesity is related to increased levels of proinflammatory circulating cytokines TNF-α and IL-1β secreted by visceral fat macrophages [13,72]; insulin resistance, which is strongly linked to obesity, is aggravated by TNF-α-IKKβ-mediated inhibitory phosphorylation of insulin receptor substrate-1 [73], etc.).…”

Section: Comorbiditiesmentioning

confidence: 99%

“…Consequently, comorbidities and metabolic alterations associated with HS include overweight, obesity, diabetes, insulin resistance, glucose intolerance, hyperlipidemia [64,65,66,68,69,70], as well as dysregulated adipokine levels [32,71], which may all be possible modulators of disease activity (e.g., obesity is related to increased levels of proinflammatory circulating cytokines TNF-α and IL-1β secreted by visceral fat macrophages [13,72]; insulin resistance, which is strongly linked to obesity, is aggravated by TNF-α-IKKβ-mediated inhibitory phosphorylation of insulin receptor substrate-1 [73], etc.). Therefore, clinicians should take into account that HS patients may have 1 or more undiagnosed components of the metabolic syndrome despite their young age, thus requiring appropriate targeted screening.…”

Section: Comorbiditiesmentioning

confidence: 99%

See 1 more Smart Citation

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Scuderi

Monfrecola

Dessy

et al. 2017

Skin Appendage Disord

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. The central pathogenic event in HS is believed to be the occlusion of the upper part of the folliculopilosebaceous unit, leading to the rupture of the sebofollicular canal with the consequent development of perifollicular lymphohistiocytic inflammation. The HS treatment choices are influenced by disease severity and its individual subjective impact, involving both medical and surgical interventions. However, given the chronic nature of HS, its destructive impact on social, working, and daily life of patients, its management is often frustrating for both the patient and physician. Hence, prompt and effective management strategies are urgently needed and a multidisciplinary approach is advocated. Therefore, in this article, we highlighted the main features of HS (clinical aspects, epidemiology, pathogenesis, diagnostic criteria, classifications, comorbidities, and treatments), so that awareness of this disease might be heightened in primary care physicians and surgeons, who may be the first health care providers to see patients with this disease owing to its characteristic clinical presentation (inflammatory nodules, abscesses, sinus tract, etc.).

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Section: Comorbiditiesmentioning

confidence: 99%

Section: Comorbiditiesmentioning

confidence: 99%

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Scuderi

Monfrecola

Dessy

et al. 2017

Skin Appendage Disord

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“…HS is also classified as an IMID, as some recent findings have focused on immunology of HS, indicating a multifactorial involvement of the immune system on the development of persistent inflammation observed in this condition [20,21,22]. Noteworthy, some data have increasingly emphasized its relationship with metabolic syndrome, which is a multifaceted disorder strongly associated with an increased risk for development of cardiovascular disease [3,4]. To the best of our knowledge, this is the first report on alterations of EPCs among HS patients.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis is still not clearly explained, however there is a link between HS and metabolic syndrome, which may be attributed to common genetic or environmental factors or shared inflammatory pathways [2]. Some recent studies have demonstrated an increased cardiovascular risk in patients with HS [3,4]. The proper function of the cardiovascular system is dependent on the wellbeing of the endothelium.…”

Section: Introductionmentioning

confidence: 99%

Decreased Number of Circulating Endothelial Progenitor Cells in Hidradenitis Suppurativa Patients

Matusiak¹,

Batycka-Baran²,

Bieniek³

et al. 2015

Dermatology

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Background: Hidradenitis suppurativa (HS) is nowadays regarded as a systemic disease associated with metabolic syndrome. Some recent studies have also demonstrated an increased cardiovascular risk in patients with HS. Circulating endothelial progenitor cells (EPCs) play an integral role in the regulation and protection of the endothelium and in the maintenance of vascular homeostasis. Objective: This study was undertaken to determine the possible alterations in the number of EPCs in patients with HS compared to controls. Methods: The number of EPCs, identified as CD133+/KDR+ cells, was determined with flow cytometry in the peripheral blood of 25 HS patients and 31 controls. Results: The number of EPCs was significantly reduced in HS sufferers compared with controls (p < 0.0001). The mean number of EPCs was assessed as 191.3 ± 118.5/ml and 672.4 ± 343.0/ml for patients and controls, respectively. Conclusion: A decreased number of EPCs among HS sufferers may contribute to endothelial malfunction resulting in increased cardiovascular risk in this group of patients.

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“…Furthermore, the recently proposed association of HS with metabolic syndrome may further add to the inflammatory status in HS as the adipose tissue acts as an active endocrine organ secreting cytokines, e.g. TNF-α [15,16,17]. Psoriasis, which is also believed to be related to Th1 cells, has been linked to metabolic syndrome as well, and additionally to hard end points, such as myocardial infarction as well as hypercoagulation and prothrombotic state [6,7,8,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study

et al. 2015

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Background: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status. Objective: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state. Methods: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]). Results: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432). Conclusion: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.

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The prevalence of metabolic syndrome in patients with hidradenitis suppurativa

Cited by 166 publications

References 28 publications

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Decreased Number of Circulating Endothelial Progenitor Cells in Hidradenitis Suppurativa Patients

Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study

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