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with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J Clin Oncol 25: Frey AB (2006) Myeloid suppressor cells regulate the adaptive immune response to cancer. J Clin Invest 116:2587-90 Gattinoni L, Ranganathan A, Surman DR et al. (2006) CTLA-4 dysregulation of self/tumorreactive CD8 þ T-cell function is CD4 þ T-cell dependent. Blood 108:3818-23 Hamid O, Robert C, Daud A et al. (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369:134-44 Hodi FS, O'Day SJ, McDermott DF et al. (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711-23 Ilkovitch D, Lopez DM (2008) Immune modulation by melanoma-derived factors. Exp Dermatol 17:977-85 Nishimura H, Nose M, Hiai H et al. (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11:141-51 Tivol EA, Borriello F, Schweitzer AN et al. (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541-7Ethnicity and Hidradenitis Suppurativa

There has been an upward trend in the use of Mohs surgery, particularly in the head and neck region where tissue preservation is essential.

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