The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein

Brits, Hanneke; Adendorff, J.; Huisamen, Dyanti; Beukes, Dahne; Botha, Kristian; Herbst, Hanre; Joubert, Gina

doi:10.4102/phcfm.v10i1.1582

Cited by 87 publications

(82 citation statements)

References 13 publications

(27 reference statements)

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“…The term ‘jaundice’ is used to describe the yellow-orange discolouration of the skin and conjunctiva due to excessive bilirubin in the skin and mucous membranes 1 2. It is not a disease, but a symptom or sign of a disease 3. Jaundice (hyperbilirubinaemia), although a common benign occurrence in the first week of life, can sometimes progress to critical levels 4.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of and mothers’ knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study

et al. 2020

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BackgroundNeonatal jaundice (NNJ) is a frequent complication of glucose-6-phosphate dehydrogenase (G6PD) deficiency.ObjectivesTo estimate the prevalence of G6PD deficiency among neonates with jaundice and to assess mothers’ perception towards G6PD and NNJ.MethodsA cross-sectional study was carried out on 487 ethnic Egyptian neonates with indirect hyperbilirubinaemia from June 2018 to July 2019. The collected data included maternal and neonatal characteristics. Laboratory investigations included serum bilirubin, reticulocyte count, ABO grouping, Rh typing and neonatal serum G6PD test. Mothers were interviewed individually using a structured, researcher-administered questionnaire to assess their perceptions of G6PD deficiency and NNJ.ResultsThe prevalence of G6PD deficiency was 10.10%. Neonates with G6PD deficiency showed higher levels of serum bilirubin (p<0.001). Male gender, family history of G6PD deficiency and consanguinity were risk factors for G6PD deficiency (OR=4.27, 95% CI 1.66 - 10.99; OR=9.54, 95% CI 4.80- 18.95; OR=10.219, 95% CI 5.39 - 19.33, respectively). Mothers’ perceptions of NNJ and G6PD were low, with only 30% having good knowledge on NNJ and 17.10% on G6PD deficiency, 46.8% with positive attitude towards NNJ and 45.0% towards G6PD deficiency, and 29.9% with good practice towards NNJ and 19.9% towards G6PD deficiency.ConclusionG6PD deficiency seems to be an important cause of NNJ. Mothers’ perceptions of both NNJ and G6PD deficiency were low. A mass health education programme on both of these diseases is needed to ensure better and early detection, good timing of treatment, and better prevention of the triggering factors to ensure better health for children.

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Section: Introductionmentioning

confidence: 99%

Prevalence of and mothers’ knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study

et al. 2020

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“…The present findings indicate that naturally delivered neonates were more likely to have jaundice than those born via cesarean section. Previous studies have shown that the risk of jaundice increases in children delivered via cesarean section [ 5 ]. Similar to our study, Bulbul et al [ 23 ] reported a statistically significant correlation between the severity of jaundice and mode of delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Jaundice itself is not a disease but rather a symptom or sign of a disease [ 5 ]. Many conditions may clinically present as prolonged neonatal jaundice, including neonatal hepatitis and extrahepatic biliary atresia.…”

Section: Introductionmentioning

confidence: 99%

Relationship between asymptomatic rotavirus infection and jaundice in neonates: a retrospective study

Hwang

Kim

2018

BMC Pediatr

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BackgroundRotavirus (RV) infection in neonates can be mild or even asymptomatic. In RV infection, jaundice is often reported, but the relationship between jaundice and RV infection has not been studied. This study aimed to determine the importance of asymptomatic RV screening in neonates with jaundice.MethodsNeonates from the neonatal intensive care unit (NICU) of Chonbuk National University Hospital, those transferred from local obstetrics and gynecology hospitals and outpatient clinics were selected from 2014 to 2017. The study included only infants aged between 3 and 28 days. Jaundice was defined according to gestational age and birth age, in accordance with the American Academy of Pediatrics guidelines criteria. RV infection was confirmed by a stool test, and RV screening and laboratory tests were performed at admission.ResultsAmong 596 patients, 166 patients had jaundice. RV infection was observed in 70 (42%) jaundice patients. There were 36 (22%) jaundice patients with asymptomatic RV infection. Patients with onset of jaundice 3–7 days after birth had a high incidence of RV infection. When the RV test was positive, the risk of jaundice was significantly high [odds ratio (OR) 1.89; 95% confidence interval (CI), 1.20–2.98; p = 0.006].ConclusionsInfants with the onset of jaundice > 3 days after birth were likely to have RV infection. Therefore, we suggest that screening tests for RV infection be included as part of the evaluation of jaundiced infants presenting to NICU.Electronic supplementary materialThe online version of this article (10.1186/s12887-018-1352-z) contains supplementary material, which is available to authorized users.

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“…The findings revealed that the mean age of the mother was 26.5 years and the mean birth weight of the neonates was 3.15 kgs and mean gestational age was 38.5 weeks. 25…”

Section: Distribution Of Sample Characteristics (Neonatal Factors)mentioning

confidence: 99%

The study of association of fetal and maternal factors in the occurrence of hyperbilirubinemia in early neonatal period

Goyal

Srivastava

2020

Int J Res Med Sci

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Background: Hyperbilirubinemia in neonates is considered to be one of the common phenomena which generally occurs during the first week of life and usually leads to NICU admission in both term and preterm new-born babies. It is also regarded as one of the most common causes which leads to neonatal morbidity and mortality.Methods: A total of 100 neonates along with their mothers were enrolled in the study from time period between 2018 to March 2019. Newborns were assessed daily for the jaundice and serum bilirubin levels were done. Various fetal-maternal factors included in proforma were. analysed to find out the association of feto-maternal factors in the occurrence of significant neonatal hyperbilirubinemia. Two groups, group A <15.7 mg/dl and group B>=15.7 mg/dl were taken. For data analysis chi square test is applied and p-value is calculated.Results: Statistically significant association between total serum bilirubin with neonatal factors like birth weight (p<0.014), maturity (p<0.011), period of gestation (p<0.003), and heart rate abnormality (p<0.005) and maternal factors like age in years (p<0.05), oral contraceptive pills use (p<0.005), and anti-epileptics use (p<0.034) were found to be linked to neonatal hyperbilirubinemia.Conclusions: Neonatal jaundice should be considered as the main policy in all health care settings of the country. Therefore, identification of factors affecting the incidence of jaundice can be effective in preventing susceptible predisposing factors in new-borns and high-risk mothers.

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The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein

Cited by 87 publications

References 13 publications

Prevalence of and mothers’ knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study

Prevalence of and mothers’ knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study

Relationship between asymptomatic rotavirus infection and jaundice in neonates: a retrospective study

The study of association of fetal and maternal factors in the occurrence of hyperbilirubinemia in early neonatal period

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