The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Dvořák, Karel; Hainer, Radvan; Petrtýl, J; Zeman, Miroslav; Vařeka, Tomáš; A, Žák; Sroubkova, Renata; Svestka, T; Vı́tek, Libor; Brůha, Radan

doi:10.5507/bp.2014.033

Cited by 11 publications

(10 citation statements)

References 41 publications

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“…21 Our study showed a significantly higher triglyceride and total cholesterol levels in T2DM patients with NAFLD than without NAFLD. This has been reported in Western studies 22 as well as in Indian studies. 6 Karel Dvorak et al have reported an elevation only in triglycerides, but not cholesterol levels.…”

Section: Selection Criteriasupporting

confidence: 77%

“…6 Karel Dvorak et al have reported an elevation only in triglycerides, but not cholesterol levels. 22 Treeprasertsuk et al reported that there is no significant difference of TG and TC levels in patients of NAFLD with low and high probability of advanced liver fibrosis by NAFLD fibrosis score at baseline. 23 It has been demonstrated that insulin resistance frequently associated with NAFLD leads to higher triglyceride synthesis and increased secretion of triglyceride from the liver.…”

Section: Selection Criteriamentioning

confidence: 99%

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A Study of Nonalcoholic Fatty Liver Disease and Fatty Liver Index in Type 2 Diabetes Mellitus Patients

M¹,

Sudha²

2016

jebmh

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BACKGROUND Nonalcoholic Fatty Liver Disease (NAFLD) is closely associated with type 2 Diabetes Mellitus (DM) and its complications. Several noninvasive diagnostic methods for NAFLD have been formulated recently. Fatty Liver Index (FLI) is one such simple method to obtain and it may help clinicians to screen type 2 DM patients for fatty liver. AIM AND OBJECTIVES 1. To know the frequency of NAFLD by ultrasound examination in type 2 DM patients of Vinayaka Missions Kirupananda Variyar Medical College and Hospital. 2. To evaluate the type 2 DM patients for risk of NAFLD by fatty liver index. MATERIALS AND METHODS A cross-sectional study was conducted on 50 nonalcoholic type 2 DM patients analysing their blood sample for lipid profile, fasting blood glucose, aspartate transaminase, alanine transaminase, gamma-glutamyl transferase levels. All the subjects had liver ultrasound examination and their anthropometric measurements noted. The Fatty Liver Index (FLI) was calculated using body mass index, waist circumference, and serum GGT. STATISTICAL ANALYSIS All the statistical work was performed by the SPSS software. To estimate the differences between patients with and without NAFLD, the Student's t-test was applied. RESULTS Out of the 50 patients, 36% (n=18) had evidence of fatty liver based on the ultrasound examination. The patients with NAFLD had significantly high BMI, cholesterol, triglycerides, GGT, and ALT levels. The variables like fasting glucose, HDL-C, LDL-C, and AST did not significantly vary between the groups. 58% (n=29) of patients had fatty liver based on FLI. The frequency of NAFLD in T2DM patients is higher when using the FLI than the ultrasound examination.

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Section: Selection Criteriasupporting

confidence: 77%

Section: Selection Criteriamentioning

confidence: 99%

A Study of Nonalcoholic Fatty Liver Disease and Fatty Liver Index in Type 2 Diabetes Mellitus Patients

M¹,

Sudha²

2016

jebmh

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“…However, there was a great disparity across studies in the estimated prevalence of NAFLD in T2DM patients, ranging from 45% to 80%. [ 14 , 15 ] This variation may be associated with the sample characteristics and the techniques used to make the diagnosis of NAFLD. [ 16 ] Therefore, this meta-analysis aimed to explore the pooled prevalence of NAFLD in T2DM patients by synthesizing the reported data.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

et al. 2017

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Background:Nonalcoholic fatty liver disease (NAFLD) is emerging as a public health issue worldwide and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). However, there was a great disparity across studies in the estimated prevalence of NAFLD in T2DM patients. This meta-analysis, therefore, aimed to estimate the pooled prevalence of NAFLD in T2DM patients.Methods:Electronic databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, and Wanfang were searched using MeSH terms to identify relevant studies. Eligibility assessment and data extraction were conducted independently by 2 investigators and a meta-analysis was performed to synthesize the data. Heterogeneity was evaluated using the Cochran Q test and quantified using the I2 statistic. Publication bias was assessed using both the Begg and Egger tests. Subgroup analyses were performed to identify the possible sources of heterogeneity.Results:Twenty-four studies involving 35,599 T2DM patients were included in this meta-analysis, of which 20,264 were identified with NAFLD. A high degree of heterogeneity (I2 = 99.0%, P < .001) was observed among the eligible studies, with the reported prevalence ranging from 29.6% to 87.1%. The pooled prevalence of NAFLD in T2DM patients, by a random-effects model, was 59.67% (95% confidence interval: 54.31–64.92%). Sensitivity was low and both the Begg test and Egger test showed low possibility of publication bias. Subgroup analyses indicated that the prevalence of NAFLD in T2DM patients differed by gender, obesity, hypertension, dyslipidemia, coronary heart disease, and chronic kidney disease.Conclusions:The high pooled prevalence of NAFLD in T2DM patients found in this study significantly underscores the need for early assessment of NAFLD and the importance of strengthening the management of NAFLD in T2DM patients.

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“…NAFLD is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type-2 diabetes (T2DM) are at a particularly high risk for developing the progressive forms of NAFLD, NASH, advanced liver fibrosis, hepatocellular carcinoma development, and liver-related mortality [ 5 ]. In these individuals, prevalence of NAFLD ranges from 42.6% [ 6 ] to 79% [ 7 ]. It is noteworthy that these numbers vary from country to country and that nearly 13% of cases have already presented signs of cirrhosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…In these individuals, prevalence of NAFLD ranges from 42.6% [ 6 ] to 79% [ 7 ]. It is noteworthy that these numbers vary from country to country and that nearly 13% of cases have already presented signs of cirrhosis [ 7 ]. In a sample of American persons with T2DM and normal serum levels of aminotransferases, prevalence of NAFLD and NASH was 76% and 56%, respectively [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease

Oliveira

Sanches

Abreu-Silva

et al. 2016

Journal of Diabetes Research

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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and it is associated with other medical conditions such as diabetes mellitus, metabolic syndrome, and obesity. The mechanisms of the underlying disease development and progression are not completely established and there is no consensus concerning the pharmacological treatment. In the gold standard treatment for NAFLD weight loss, dietary therapy, and physical activity are included. However, little scientific evidence is available on diet and/or physical activity and NAFLD specifically. Many dietary approaches such as Mediterranean and DASH diet are used for treatment of other cardiometabolic risk factors such as insulin resistance and type-2 diabetes mellitus (T2DM), but on the basis of its components their role in NAFLD has been discussed. In this review, the implications of current dietary and exercise approaches, including Brazilian and other guidelines, are discussed, with a focus on determining the optimal nonpharmacological treatment to prescribe for NAFLD.

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The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Cited by 11 publications

References 41 publications

A Study of Nonalcoholic Fatty Liver Disease and Fatty Liver Index in Type 2 Diabetes Mellitus Patients

A Study of Nonalcoholic Fatty Liver Disease and Fatty Liver Index in Type 2 Diabetes Mellitus Patients

Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease

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