The prevalence of sleep-disordered breathing in Northwest Russia: The ARKHsleep study

Khokhrina, A. I.; Andreeva, Elena; Degryse, Jean-Marie

doi:10.1177/1479973120928103

Cited by 21 publications

(12 citation statements)

References 51 publications

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“…A recent study found that out of 38,000 Russian citizens (aged 30–70 years), 48.9% suffered from an AHI (Apnea-Hipopnea Index) ≥ 5, 18.1% from an AHI ≥ 15 and 4.5% from an AHI ≥ 30 [ 4 ]. In 2020, Peñafiel et al observed 205 people (aged between 18–84 years) undergoing overnight respiratory polygraphy and they found a prevalence of 49% AHI ≥ 5 and 16% AHI ≥ 15 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Obstructive Sleep Apnea Syndrome: A Single-Center Retrospective Study

Santilli

Manciocchi

D’Addazio

et al. 2021

IJERPH

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Obstructive sleep apnea syndrome (OSAS) is a sleep breathing disorder that often remains undiagnosed and untreated. OSAS prevalence is increasing exponentially. Starting on the dentist’s role as an epidemiological and diagnostic “sentinel”, the purpose of this study was to assess the prevalence of OSAS. The clinical diaries of 4659 patients were reviewed through a single-center retrospective analytic study. Descriptive statistical analysis was performed. Only 0.26% of patients reported to suffer from sleep apnea and were then diagnosed with OSAS. It was found that, out of 4487 patients, 678 suffered from hypertension (14.80%), 188 from gastro-esophageal-reflux-disease (GERD = 4.10%) and 484 from gastritis (10.78%). These results could be related to a difficult diagnosis of OSAS and to the absence of a dedicated section on sleep disorders in medical records. Therefore, the introduction of a question dedicated to sleep disorders, the administration of questionnaires (such as the STOP-BANG questionnaire) for early diagnosis, a multidisciplinary approach and pneumological examination could support the dentist in identifying patients at risk of OSAS.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Obstructive Sleep Apnea Syndrome: A Single-Center Retrospective Study

Santilli

Manciocchi

D’Addazio

et al. 2021

IJERPH

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“…As a common sleep disorder disease, OSAS is characterized by sudden pauses of breathing during sleep (Khokhrina et al 2020 ). Resulting from repeated obstructions of the pharyngeal airway, CIH is a cardinal feature of OSAS, which induces degrease of cognitive performance (Li et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Hou

et al. 2022

Mol Med

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The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal nerve and glia cells of C57BL/6 mice, and caused severe neuro damage including neuron lesions, neuroblast (NB) apoptosis and abnormal glial activation. Studies have shown that the neuronal metabolism disorders might contribute to the CIH induced-hippocampal impairment. Mechanistically, the results showed that pyruvate dehydrogenase complex E1ɑ subunit (PDHA1) and the pyruvate dehydrogenase complex (PDC) activator pyruvate dehydrogenase phosphatase 1 (PDP1) did not noticeable change after intermittent hypoxia. Consistent with those results, the level of Acetyl-CoA in hippocampus did not significantly change after CIH exposure. Interestingly, we found that CIH produced large quantities of ROS, which activated the JNK/SREBP/ACC pathway in nerve and glia cells. ACC catalyzed the carboxylation of Acetyl-CoA to malonyl-CoA and then more lipid acids were synthesized, which finally caused aberrant LDs accumulation. Therefore, the JNK/SREBP/ACC pathway played a crucial role in the cognitive deficits caused by LDs accumulation after CIH exposure. Additionally, LDs were peroxidized by the high level of ROS under CIH conditions. Together, lipid metabolic disorders contributed to nerve and glia cells damage, which ultimately caused behavioral dysfunction. An active component of Salvia miltiorrhiza, SMND-309, dramatically alleviated these injuries and improved cognitive deficits of CIH mice.

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“…OSAS is a disease that is common among middle-aged and older adults, and it affects 26% of individuals between the ages of 30 and 70 in the USA [ 4 ]. In Russian citizens, this rate is 48.9% [ 5 ]. In 2020, S aldías P eñafiel et al .…”

Section: Introductionmentioning

confidence: 99%

Investigation of the frequency of obstructive sleep apnoea syndrome in patients with subclinical hypothyroidism

et al. 2022

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BackgroundThe aim of this study is to determine the frequency of Obstructive Sleep Apnea Syndrome (OSAS) in a study group with the diagnosis of subclinical hypothyroidism and in a control group without the diagnosis of subclinical hypothyroidism. This study compares these two groups in terms of demographic characteristics, chronic diseases, and especially polysomnographic data.MethodsA total of 120 patients were included in this study. They consistedof 60 patients with newly diagnosed subclinical hypothyroidism, and a control group of 60 patients with normal thyroid functions. Demographic, anthropometric, polysomnography data, and Epworth sleepiness scale scores of the patients were recorded and compared.ResultsAny significant difference in the frequency and severity of OSAS was not detected. A significant difference was found in the oxygen desaturation index (ODI), the apnea-hypopnea index (AHI) in REM sleep, the AHI in supine sleep position, and the arousal index of the group experiencing subclinical hypothyroidism with OSAS.ConclusionThis study showed that there was no increase in OSAS frequency in patients with subclinical hypothyroidism, but it demonstrated that the ODI and the arousal index were significantly increased in OSAS patients diagnosed with subclinical hypothyroidism. It is thought that the diagnosis and treatment of OSAS in these patients may be important in preventing cardiovascular complications.

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The prevalence of sleep-disordered breathing in Northwest Russia: The ARKHsleep study

Cited by 21 publications

References 51 publications

Prevalence of Obstructive Sleep Apnea Syndrome: A Single-Center Retrospective Study

Prevalence of Obstructive Sleep Apnea Syndrome: A Single-Center Retrospective Study

Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Investigation of the frequency of obstructive sleep apnoea syndrome in patients with subclinical hypothyroidism

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