The Prevalence of Symptoms Suggestive of Esophageal Disorders

Ruth, Magnus; Månsson, Ingemar; Sandberg, N

doi:10.3109/00365529108996486

Cited by 153 publications

(126 citation statements)

References 17 publications

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“…Previous epidemiological findings concerning the associations between smoking habit and GERD, FD, or IBS have been inconclusive (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Several studies have shown that smoking is significantly associated with GERD (10-13), uninvestigated dyspepsia (14-16), postprandial distress syndrome (a subtype of FD) (17,18), and IBS (19,20), especially, in female IBD (21) and diarrhea-predominant IBS (22).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, physicians should pay attention to the overlapping of functional GI disorders. There are several studies concerning risk factors associated with GERD, FD, or IBS (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Our previous study showed that smoking and drinking habits were associated with GERD (13); female gender, low body mass index (BMI), smoking and drinking habits with FD (18); younger age, female gender, low BMI and presence of allergic diseases with IBS (22).…”

Section: Introductionmentioning

confidence: 99%

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Cigarette Smoking and its Association with Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome

et al. 2011

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Background Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common gastrointestinal diseases. Several studies have shown a significant occurrence of overlap among these 3 diseases. The purpose of this study was to examine the factors associated with such disease overlap in Japanese adults. Methods We performed a cross-sectional study on Japanese workers who visited a clinic for a routine health check-up and asked them to fill out a self-report questionnaire. GERD was defined as episodes of heartburn and/or acid regurgitation at least once a week, and the diagnosis of FD and IBS was based on Rome III criteria. A logistic regression model was used to identify risk factors, and odds ratio (OR) was calculated with 95% confidence intervals (CIs). Results Disease overlaps were found in 160 (6.0%) of the 2680 eligible subjects. Female gender was associated with GERD + IBS (OR=1.99; 95% CI, 1.06-3.75), and FD + IBS (OR=1.72; 95% CI, 1.03-2.85), and lower body mass index was negatively associated with FD + IBS (OR=0.54; 96% CI, 0.34-0.87). Cigarette smoking was a common factor associated with the overlaps: GERD + FD (OR=2.14; 95% CI, 1.22-3.76), GERD + IBS (OR=3.16; 95% CI, 1.75-3.71), FD + IBS (OR=2.26; 95% CI, 1.40-3.66), and GERD + FD + IBS (OR=4.08; 95% CI, 1.66-10.07). The associations between smoking habits and overlaps were stronger in smokers who smoked !1 pack per day as compared to those who smoked <1 pack per day. Conclusion Cigarette smoking was significantly associated with overlaps among GERD, FD, and IBS in Japanese adults.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cigarette Smoking and its Association with Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome

et al. 2011

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“…The prevalence of dysphagia in the general population is not well established, but several studies have suggested that between 7% and 10% of adults are affected. 11,12 Complaints about dysphagia appear to increase with age, but usually are not attributed to the ageing process itself. 13 Dysphagia is not uncommonly associated with oesophageal manometric findings which may be present with chest pain symptoms as well.…”

Section: Introductionmentioning

confidence: 99%

Assessment of oesophageal motor function in patients with dysphagia or chest pain — the Clinical Outcomes Research Initiative experience

Dekel

Pearson

Wendel

et al. 2003

Aliment Pharmacol Ther

109

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SUMMARYBackground: Available prospectively acquired data on the distribution of oesophageal motor abnormalities in patients being evaluated for non-cardiac chest pain and/or dysphagia are relatively scarce. Aim: To evaluate the distribution of oesophageal motor abnormalities in patients with dysphagia, non-cardiac chest pain or both using the national Clinical Outcomes Research Initiative (CORI) database. Methods: The CORI oesophageal motility database originates from 19 community, university and VA medical centres. Data were collected using a computerized motility report-generating program, combined with the CORI module. Data from each site were encrypted and sent to the CORI National Repository for analysis. The database includes the assessment of the lower and upper oesophageal sphincter function and the motor activity of the oesophageal body. Results: Five hundred and eighty-seven consecutive patients who underwent motility studies between 1998 and 2001 were included in the CORI database and analysed for this report. Four hundred and three patients (69%) had dysphagia as their primary indicator for the examination, 140 patients (24%) had non-cardiac chest pain and 44 patients (7%) had

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“…Gastroesophageal reflux disease, one of the most prevalent health disorders in the Western world (7)(8)(9), is strongly associated with adenocarcinoma of the esophagus (5,(10)(11)(12), which stands in sharp contrast to the lack of association between reflux and squamous cell carcinoma of the esophagus (5,10). A link between gastroesophageal reflux and laryngeal and pharyngeal cancers has also been suggested, based on results from several case series (13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

No Association between Gastroesophageal Reflux and Cancers of the Larynx and Pharynx

Nilsson

Chow

Lindblad

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Purpose: To examine the proposed relation between gastroesophageal reflux disease and cancers of the larynx and pharynx. Experimental Design: A cohort of 66,965 patients with discharge diagnoses of heartburn, hiatal hernia, or esophagitis was identified in the Swedish Inpatient Register. We observed a total of 376,622 person-years in the cohort. Identification of laryngeal and pharyngeal cancers was achieved through the Swedish Cancer Register. Standardized incidence ratios, the ratio of the observed to the expected number of cancers, derived from the general Swedish population and adjusted for sex, age, and calendar year, was used to estimate the relative risk. Results: During follow-up, 30 cases of laryngeal and 31 cases of pharyngeal cancer were detected in the cohort. Slightly increased risks of laryngeal [relative risk, 1.6; 95% confidence interval (CI), 1.1-2.2] and pharyngeal carcinomas (relative risk, 1.9; 95% CI, 1.3-2.8) were observed in the total reflux cohort. After stratification to exclude cohort members with a diagnosis of alcoholism, no significant increase in the risk of laryngeal (relative risk, 1.3; 95% CI, 0.8-2.0) or pharyngeal carcinomas (relative risk, 1.0; 95% CI, 0.5-1.6) was found compared with the general population. Furthermore, there were no dose-response patterns of the risk for laryngeal and pharyngeal cancers with years of cohort follow-up, indicators of reflux severity, or specificity of reflux diagnosis.

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The Prevalence of Symptoms Suggestive of Esophageal Disorders

Cited by 153 publications

References 17 publications

Cigarette Smoking and its Association with Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome

Cigarette Smoking and its Association with Overlapping Gastroesophageal Reflux Disease, Functional Dyspepsia, or Irritable Bowel Syndrome

Assessment of oesophageal motor function in patients with dysphagia or chest pain — the Clinical Outcomes Research Initiative experience

No Association between Gastroesophageal Reflux and Cancers of the Larynx and Pharynx

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