The prevalence of Type 2 Diabetes Mellitus in the United Arab Emirates: justification for the establishment of the Emirates Family Registry

Alsafar, Habiba; Jama-Alol, Khadra; Hassoun, Ahmed; Tay, Guan K.

doi:10.1007/s13410-012-0062-6

Cited by 32 publications

(19 citation statements)

References 14 publications

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“…28 Isolated reports from Asia suggest a rising prevalence of early onset T2D, 29 with around 2-3% of T2D with onset under 20 years in south and east Asia 30 and the Arab world. 31…”

Section: Epidemiologymentioning

confidence: 99%

Type 2 diabetes in adolescents: a severe phenotype posing major clinical challenges and public health burden

2017

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Type 2 diabetes in adolescence manifests as a severe progressive form of diabetes that frequently presents with complications, responds poorly to treatment, and results in rapid progression of microvascular and macrovascular complications. Although overall still a rare disease, adolescent type 2 diabetes now poses major challenges to paediatric and adult diabetes services in many countries. Therapeutic options are heavily curtailed by a dearth of knowledge about the condition, with low numbers of participants and poor trial recruitment impeding research. Together with lifestyle modification, metformin remains the first-line therapy for adolescents with type 2 diabetes, although the majority rapidly progress to treatment failure and insulin therapy. Early bariatric surgery is controversial but has great potential to transform outcomes. Health systems must respond by both concentrating patients in specialist clinical services integrated with translational research programmes, but also by joining up with local health and social care services to improve engagement and uptake of services.

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“…28 Isolated reports from Asia suggest a rising prevalence of early onset T2D, 29 with around 2-3% of T2D with onset under 20 years in south and east Asia 30 and the Arab world. 31…”

Section: Epidemiologymentioning

confidence: 99%

Type 2 diabetes in adolescents: a severe phenotype posing major clinical challenges and public health burden

2017

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“…DNA samples from individuals who provided consent to have their de-identified DNA samples stored for research purposes were obtained from the Emirates Family Registry (EFR) [8]. Prior to commencement of this study, approval to undertake the Locus-by-locus exact tests using Arlequin v3.5.2.1 Software were carried out in this study [10].…”

Section: Dear Editormentioning

confidence: 99%

Population data for 21 autosomal short tandem repeat markers in the Arabic population of the United Arab Emirates

Jones

Tayyare

Tay

et al. 2017

Forensic Science International: Genetics

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“…However, cases were not assessed for other psychiatric disorders at the time of recruitment. Controls with no prior history of SUD were retrieved from the Emirates Family Registry (EFR) [24] as a control group. However, other diseases were included in the control group selection criteria such as diabetes, cardiovascular diseases, dyslipidaemia, etcetera.…”

Section: Participantsmentioning

confidence: 99%

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent

et al. 2020

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Background: Genome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved in development of opioid use disorder. This study extends the first GWAS of substance use disorder (SUD) patients from the United Arab Emirates (UAE) by stratifying the study group based on opioid use, which is the most common substance of use in this cohort. Methods: The GWAS cohort consisted of 512 (262 case, 250 controls) male participants from the UAE. The samples were genotyped using the Illumina Omni5 Exome system. Data was stratified according to opioid use using PLINK. Haplotype analysis was conducted using Haploview 4.2. Results: Two main associations were identified in this study. Firstly, two SNPs on chromosome 7 were associated with opioid use disorder, rs118129027 (p-value = 1.23 × 10 − 8) and rs74477937 (p-value = 1.48 × 10 − 8). This has been reported in Alblooshi et al. (Am J Med Genet B Neuropsychiatr Genet 180(1):68-79, 2019). Secondly, haplotypes on chromosome 2 which mapped to the KIAA1211L locus were identified in association with opioid use. Five SNPs in high linkage disequilibrium (LD) (rs2280142, rs6542837, rs12712037, rs10175560, rs11900524) were arranged into haplotypes. Two haplotypes GAGCG and AGTTA were associated with opioid use disorders (p-value 3.26 × 10 − 8 and 7.16 × 10 − 7 , respectively). Conclusion: This is the first GWAS to identify candidate genes associated with opioid use disorder in participants from the UAE. The lack of other genetic data of Arabian descent opioid use patients has hindered replication of the findings. Nevertheless, the outcomes implicate new pathways in opioid use disorder that requires further research to assess the role of the identified genes in the development of opioid use disorder.

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The prevalence of Type 2 Diabetes Mellitus in the United Arab Emirates: justification for the establishment of the Emirates Family Registry

Cited by 32 publications

References 14 publications

Type 2 diabetes in adolescents: a severe phenotype posing major clinical challenges and public health burden

Type 2 diabetes in adolescents: a severe phenotype posing major clinical challenges and public health burden

Population data for 21 autosomal short tandem repeat markers in the Arabic population of the United Arab Emirates

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent

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