The preventive effect and underlying mechanism of <i>Rhus chinensis</i> Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice

Zhang, Yi; Wang, Ou; Yi, Junjie; Mi, Hongying; Cai, Shengbao

doi:10.1039/d1fo01558c

Cited by 23 publications

(11 citation statements)

References 66 publications

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“…In previous studies, tannin [ 15 ], flavonoids [ 9 ], carbohydrates [ 13 ] and other chemicals were found in the secondary metabolites of various extracts of water caltrop husk [ 13 , 15 ]. These chemicals are also known as lifetime metabolites of plants, and have been reported with some bioactivities, such as improving diabetes [ 19 ], cancer [ 22 , 23 ], gastric ulcer [ 24 ], alcoholic fatty liver disease [ 25 ], nonalcoholic fatty liver disease [ 26 ] and colitis [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Water Caltrop (Trapa quadrispinosa Roxb.) Husk Improves Oxidative Stress and Postprandial Blood Glucose in Diabetes: Phenolic Profiles, Antioxidant Activities and α-Glycosidase Inhibition of Different Fractions with In Vitro and In Silico Analyses

Zhang

Cai

et al. 2022

Antioxidants

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The aim of this study was to investigate the phenolic profiles, antioxidant activities and α-glycosidase inhibitory activities of three different phenolic fractions from water caltrop (Trapa quadrispinosa Roxb.) husk and to further explore the predominant compounds and their mechanisms on α-glycosidase inhibition by virtual screening and molecular dynamics. A total of 29 substances were identified and quantified in this study. Tannins were the main constituents of water caltrop husk extract. All of the free phenolic (FP), esterified phenolic (EP) and insoluble-bound phenolic (BP) fractions exhibited good antioxidant activities, and the BP had the highest radical scavenging ability with IC50 values of 0.82 ± 0.12 μg/mL (ABTS) and 1.15 ± 0.02 μg/mL (DPPH), respectively (p < 0.05). However, compared with the EP and BP, the FP showed the strongest inhibition towards the α-glycosidase and the IC50 value of FP was 1.43 ± 0.12 μg/mL. The 1,2,6-trigalloylglucose and α-glycosidase complex had better root mean square deviations (RMSD) stability via molecular dynamics simulation study. Results obtained from this study may provide a good potential natural resource for the improvement of oxidative stress injury and blood glucose control in diabetes mellitus, which could expand the use of water caltrop husk and improve its economic value.

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Section: Resultsmentioning

confidence: 99%

Water Caltrop (Trapa quadrispinosa Roxb.) Husk Improves Oxidative Stress and Postprandial Blood Glucose in Diabetes: Phenolic Profiles, Antioxidant Activities and α-Glycosidase Inhibition of Different Fractions with In Vitro and In Silico Analyses

Zhang

Cai

et al. 2022

Antioxidants

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“…Various proinflammatory cytokines, such as, tumor necrosis factor-alpha (TNF-α) and interleukins (ILs) get overexpressed under the influence of activated mast cells and innate immune response at the site of inflammation. , These mediators play a crucial role in the pathogenesis of UC and other related inflammatory diseases. , The exaggerated inflammatory responses adversely affect the colon homeostasis that leads to the development and progression of disease. , …”

Section: Resultsmentioning

confidence: 99%

Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis

Mishra¹,

Ahmad

Kanika³

et al. 2022

Mol. Pharmaceutics

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Ulcerative colitis is a multifactorial disease of the gastrointestinal tract which is caused due to chronic inflammation in the colon; it usually starts from the lower end of the colon and may spread to other portions of the large intestine, if left unmanaged. Budesonide (BUD) is a synthetically available second-generation corticosteroidal drug with potent local anti-inflammatory activity. The pharmacokinetic properties, such as extensive first-pass metabolism and quite limited bioavailability, reduce its therapeutic efficacy. To overcome the limitations, nanosized micelles were developed in this study by conjugating stearic acid with caffeic acid to make an amphiphilic compound. The aim of the present study was to evaluate the pharmacological potential of BUD-loaded micelles in a mouse model of dextran sulfate sodium-induced colitis. Micelles were formulated by the solvent evaporation method, and their physicochemical characterizations show their spherical shape under microscopic techniques like atomic force microscopy, transmission electron microscopy, and scanning electron microscopy. The in vitro release experiment shows sustained release behavior in physiological media. These micelles show cytocompatible behavior against hTERT-BJ cells up to 500 μg/mL dose, evidenced by more than 85% viable cells. BUD-loaded micelles successfully normalized the disease activity index and physical observation of colon length. The treatment with BUD-loaded micelles alleviates the colitis severity as analyzed in histopathology and efficiently, overcoming the disease severity via downregulation of various related cytokines (MPO, NO, and TNF-α) and inflammatory enzymes such as COX-2 and iNOS. Results of the study suggest that BUD-loaded nano-sized micelles effectively attenuate the disease conditions in colitis.

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“…Therefore, further studies are needed to investigate the phenolic compounds that play a major role in DDC-induced cholestasis, and the structure-activity relationships and synergies between these compounds, which will contribute to a better understanding and application of dietary phenolic substances to prevent DDC-induced cholestasis. Zhang et al [ 48 ] studied the effect of ethanol extracts of RCM fruits on dextran sodium sulfate-induced colitis in C57 mice at a dose of 400 and 800 mg/kg b.w., the results showed that these two doses had no toxic effect on mice, and could exert good antioxidant and anti-inflammatory effects. Therefore, the selection of concentration in this paper was consistent with Zhang et al Moreover, preliminary conversion [ 49 ] demonstrated that the intake of 400 and 800 mg/kg b.w.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation

et al. 2022

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This study focused on the preventive effects of the extracts of Rhus chinensis Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, including (1) alleviating liver damage via enhancing antioxidant capacity, such as increasing the contents of glutathione, superoxide dismutase, and catalase and inhibiting the levels of malondialdehyde; (2) preventing liver inflammation by suppressing NF-κB pathway and reducing proinflammatory cytokines secretion (e.g., tumor necrosis factor-α, interleukin-1β, and interleukin-6); (3) inhibiting liver fibrosis and collagen deposition by regulating the expression of transforming growth factor-β and α-smooth muscle actin; (4) modulating abnormal bile acid metabolism through increasing the expression of bile salt export pump and multidrug resistance-associated protein 2. This study was the first to elucidate the potential preventive effect of RCM extracts on DDC-induced cholestasis in mice from multiple pathways, which suggested that RCM fruits could be considered as a potential dietary supplement to prevent cholestasis.

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The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice

Abstract: The purpose of this research was to explore the preventative effect of the 80% ethanol extract of Rhus chinensis Mill. fruits on dextran sulfate sodium (DSS)-induced colitis in mice and...

Cited by 23 publications

References 66 publications

Water Caltrop (Trapa quadrispinosa Roxb.) Husk Improves Oxidative Stress and Postprandial Blood Glucose in Diabetes: Phenolic Profiles, Antioxidant Activities and α-Glycosidase Inhibition of Different Fractions with In Vitro and In Silico Analyses

Water Caltrop (Trapa quadrispinosa Roxb.) Husk Improves Oxidative Stress and Postprandial Blood Glucose in Diabetes: Phenolic Profiles, Antioxidant Activities and α-Glycosidase Inhibition of Different Fractions with In Vitro and In Silico Analyses

Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation

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