The price of immunotherapy

Penn, Israel

doi:10.1016/s0011-3840(81)80011-1

Cited by 73 publications

(14 citation statements)

References 146 publications

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“…These conclusions are important in view of the fact that chronically-immunosuppressed patients are at a greatly increased risk of developing lymphomas (Kinlen et d . , 1979;Penn, 1981) which are very often, if not always, EB virus genome-positive (Crawford ef al., 1980;Hanto et a/., 1981Hanto et a/., . 1983.…”

Section: * * II 111mentioning

confidence: 99%

In vitro analysis of the epstein‐barr virus: Host balance in long‐term renal allograft recipients

Yao

Rickinson

Gaston

et al. 1985

Intl Journal of Cancer

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Four indices of the EB virus carrier state, for which quantitative in vitro assays now exist, have been monitored in 55 renal allograft recipients under long-term immunosuppression, each patient being tested on a single occasion. By comparison with parallel data from healthy control donors, the results indicate the extent to which virus replication in the throat and virus-infected B cells in the blood are increased as a result of immunosuppression; the concordance between these two independent indices of the level of EB virus infection in vivo, first noted with healthy donors, was again observed within this large group of patients. Immunosuppression also leads to an impairment of virus-specific memory T-cell responsiveness and to an increase in anti-viral antibody titres, but the results show that the level of virus infection prevailing in any one individual cannot be inferred directly from these immunological indices of the virus:host balance. In allograft patients on stable levels of immunosuppression, virus and host appear to establish a new equilibrium. Limited prospective studies suggest that the position of this new equilibrium depends critically upon the virus:host balance prevailing in the same individuals before immunosuppression began. This may be an important consideration in identifying patients for whom immunosuppression may carry a particularly high risk of developing EB virus genome-positive lymphoma.

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Section: * * II 111mentioning

confidence: 99%

In vitro analysis of the epstein‐barr virus: Host balance in long‐term renal allograft recipients

Yao

Rickinson

Gaston

et al. 1985

Intl Journal of Cancer

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“…1,2 The dimensions of the hazard have been followed by Penn 3 through a registry to which transplantation surgeons throughout the world have contributed. Meanwhile, evidence has accumulated that lymphomas in patients with natural or iatrogenic immunodeficiency may be associated with infection by the Epstein-Barr virus.…”

Section: Introductionmentioning

confidence: 99%

Reversibility of Lymphomas and Lymphoproliferative Lesions Developing Under Cyclosporin-Steroid Therapy

Starzl¹,

Porter²,

Iwatsuki³

et al. 1984

The Lancet

1,156

451

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SummaryPost-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts. Reduction or discontinuance of immunosuppression caused regression of the lesions, often without subsequent rejection of the grafts. Chemotherapy and irradiation were not valuable. The findings may influence policies about treating other kinds of posttransplantation neoplasms.

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“…In 1969, the firse 86 of a series of reports from this Center185, [187][188][189][190][191][192][193] defined the clinical dimensions of transplant-associated tumors. In 1970, the suggestion of reducing immunosuppression as a form of therapy for these tumors was first proposed.…”

Section: Introductionmentioning

confidence: 99%