The primary structure of a feline class I gene: Striking similarity toHLA-A

Hoof, M van; Geus, J P de; Roos, Marleen H.; Brown, Colin B.; Jacobs, Heinz; Ploegh, Hidde L.

doi:10.1007/bf02425272

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…The intact Hi-RARE was also conserved in MHC class I genes of the rat (27), rhesus macaque (28) and cat (29). In the rabbit (30) everted repeat was partially altered: TGACCC (N12) AGcTCg.…”

Section: Hi-rare Sequence Is Highly Conserved In Mhc Class I Genes Of...mentioning

confidence: 99%

A Novel Type of Retinoic Acid Response Element in the Second Intron of the Mouse H2Kb Gene is Activated by the RAR/RXR Heterodimer

Jansa

Forejt

1996

Nucleic Acids Research

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We have identified and characterized a novel retinoic acid (RA) response element (Hi-RARE) in the second intron of the mouse major histocompatibility H2Kb gene. The Hi-RARE sequence is conserved in all mouse classical and Q class 1 genes, in MHC class 1 genes of the rat, Rhesus macaque, cat and in the vast majority of human classical and non-classical class 1 genes. The Hi-RARE sequence lies within a regulatory element responsible for constitutive expression of a 5' enhancerless H2Kb gene in the Ltk-fibroblasts. Hi-RARE consists of two inverted palindromic RARE consensus sites (5'-PuGGTCA-3') separated by an 8 nt spacer. Mutational analysis revealed that both inverted palindromic hexanucleotide motifs are indispensable functional sites for the 9-cis RA response. The Hi-RARE sequence confers 9-cis RA inducibility to a heterologous promoter. The inducibility is further augmented in embryonal carcinoma cells by the expression of recombinant retinoic acid receptors (PARs) and the retinoid X receptors (RXRs). In vitro, the recombinant RAR/RXR heterodimer creates DNA-protein complex with the Hi-RARE sequence. Treatment of P19 embryonal carcinoma cells with 9C-RA induces the Hi-RARE binding activity of nuclear proteins that proved to be RAR (or RAR-Like)/RXR heterodimer. Thus the Hi-RARE represents a new type of RA response element with a role in the modulation of the expression of MHC class 1 family genes.

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“…The intact Hi-RARE was also conserved in MHC class I genes of the rat (27), rhesus macaque (28) and cat (29). In the rabbit (30) everted repeat was partially altered: TGACCC (N12) AGcTCg.…”

Section: Hi-rare Sequence Is Highly Conserved In Mhc Class I Genes Of...mentioning

confidence: 99%

A Novel Type of Retinoic Acid Response Element in the Second Intron of the Mouse H2Kb Gene is Activated by the RAR/RXR Heterodimer

Jansa

Forejt

1996

Nucleic Acids Research

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Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.

Flajnik

Canel

Kramer

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like a-3 domain is more similar to the immunoglobulin-like domains of mammalian class II (3 chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.

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The primary structure of a feline class I gene: Striking similarity toHLA-A

Cited by 2 publications

References 28 publications

A Novel Type of Retinoic Acid Response Element in the Second Intron of the Mouse H2Kb Gene is Activated by the RAR/RXR Heterodimer

A Novel Type of Retinoic Acid Response Element in the Second Intron of the Mouse H2Kb Gene is Activated by the RAR/RXR Heterodimer

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.

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