The PRObiotics in Pediatric Asthma Management (PROPAM) study: A post hoc analysis in preschoolers

Ciprandi, Giorgio; Cioffi, Luigi; Giuliano, Maria; Pane, Marco; Drago, Lorenzo

doi:10.1002/ppul.25878

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The Relevance Of Propam Study In Asthma Management1

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2022

2023

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“…In addition, as the age range was relatively wide, two post hoc analyses were performed to confirm the outcomes in preschoolers and schoolchildren [ 86 , 87 ]. Both analyses confirmed the results obtained in the whole population.…”

Section: The Relevance Of Propam Study In Asthma Managementmentioning

confidence: 99%

Probiotics in Children with Asthma

Ciprandi

Tosca

2022

Children

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A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate airway inflammation. As a result, probiotics may prevent asthma and wheezing relapse. There is evidence that some probiotic strains may improve asthma outcomes in children. In this context, the PROPAM study provided evidence that two specific strains significantly prevented asthma exacerbations and wheezing episodes. Therefore, oral probiotics could be used as add-on asthma therapy in managing children with asthma, but the choice should be based on documented evidence.

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Section: The Relevance Of Propam Study In Asthma Managementmentioning

confidence: 99%