The problem in total joint arthroplasty

Goldring, Steven R.; Clark, Charles R.; Tw, Wright

doi:10.2106/00004623-199306000-00001

Cited by 155 publications

(57 citation statements)

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“…Loosening of total joint replacement appears to result in part from the production and accumulation of particles at the prosthetic interface and the subsequent biological reaction [1][2]. Although metallic and polyethylene particles have been studied [3], little is known about the cellular response to hydroxyapatite (HA) despite the wide use of these materials [4].…”

Section: Introductionmentioning

confidence: 99%

MMP-2, MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles

Laquerrière

Grandjean-Laquerriere²,

Addadi-Rebbah

et al. 2004

Biomaterials

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After calcium-phosphates biomaterials based implantation like hydroxyapatite coating, particles are released in the periprosthetic tissues. Fibrous tissue around wear debris are mainly made of monocytes that can be produced metalloprotease (MMP), considered to be the key enzymes in extracellular matrix turnover. Tissue inhibitors of metalloproteinases are important regulator of MMPs activity. Interleukin-1 mainly produced by monocytes can also regulate MMPs production. In the present work, we have evaluated the effect of hydroxyapatite particles characteristics (size, shape and sintering temperature) on the MMP-2, -9 and their inhibitors TIMP-2, -1 production. Our results demonstrate that sintering temperature (that modify crystal size and surface area) have few effect on MMPs and TIMPs production. Not-phagocytable particles induced more MMP-9, altough phagocytable particles induced more IL-1β production. The shape of the particles was the most important factor since needle particles induced the most important quantity of MMPs and IL-1β.

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Section: Introductionmentioning

confidence: 99%

MMP-2, MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles

Laquerrière

Grandjean-Laquerriere²,

Addadi-Rebbah

et al. 2004

Biomaterials

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“…The latter is associated with the generation and accumulation of foreign-body wear debris at the prosthetic interface. [1][2][3] The wear debris incites the formation of granulomata localised to the sites of loosened implants. [4][5][6] Histological analysis of the granulomatous tissue has shown the presence of abundant particulate debris surrounded by numerous macrophages, foreign-body giant cells and fibroblasts.…”

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confidence: 99%

Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles

Nakashima

Sun

Trindade

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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Particulate wear debris is associated with periprosthetic inflammation and loosening in total joint arthroplasty. We tested the effects of titanium alloy (Ti-alloy) and PMMA particles on monocyte/macrophage expression of the C-C chemokines, monocyte chemoattractant protein-1 (MCP-1), monocyte inflammatory protein-1 alpha (MIP-1␣), and regulated upon activation normal T expressed and secreted protein (RANTES). Periprosthetic granulomatous tissue was analysed for expression of macrophage chemokines by immunohistochemistry. Chemokine expression in human monocytes/macrophages exposed to Ti-alloy and PMMA particles in vitro was determined by RT-PCR, ELISA and monocyte migration.We observed MCP-1 and MIP-1␣ expression in all tissue samples from failed arthroplasties. Ti-alloy and PMMA particles increased expression of MCP-1 and MIP-1␣ in macrophages in vitro in a dose-and time-dependent manner whereas RANTES was not detected. mRNA signal levels for MCP-1 and MIP-1␣ were also observed in cells after exposure to particles. Monocyte migration was stimulated by culture medium collected from macrophages exposed to Ti-alloy and PMMA particles. Antibodies to MCP-1 and MIP-1␣ inhibited chemotactic activity of the culture medium samples.Release of C-C chemokines by macrophages in response to wear particles may contribute to chronic inflammation at the bone-implant interface in total joint arthroplasty.J Bone Joint Surg [Br] 1999;81-B:155-62.

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“…Of the different types of particle found in the membranes surrounding the loosened components, polyethylene debris has been identified as a major factor inducing activation of macrophages which leads to the production of bone-resorbing cytokines with resultant loss of bone stock, especially in the young and active population. 1 Pierre Boutin 2 first introduced ceramics in orthopaedics in the early 1970s in order to eliminate or reduce complications related to polyethylene. 3 They are mainly used in total hip arthroplasty as femoral heads articulating against polyethylene, and as cups in the alumina-on-alumina combination.…”

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confidence: 99%