The Problem of the Treatment of Fracture in Long Bone

Matsuda, Shinya; Takaoka, Takanori; Matsukuma, Y.; Nagatomi, Hideyuki; Aoyama, S.

doi:10.5035/nishiseisai.10.174

Orthopedics & Traumatology

1961

DOI: 10.5035/nishiseisai.10.174

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The Problem of the Treatment of Fracture in Long Bone

Shinya Matsuda

Takanori Takaoka

Y. Matsukuma

et al.

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1989

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“…It is suggested that the mechanical force induces electric potentials on bone surfaces. In other words, changes in the electric potential on bone surfaces appear to act as a mediator of mechanical stress (Yasuda, 1953;Bassett and Becker, 1962;Bryant and Wolfe, 1987). The electric field or current induced by the electric potentials on bone surfaces has also been reported to affect bone cells (Ficat et al, 1984;Korenstein et al, 1984;Laub and Korenstein, 1984;Noda et al, 1987).…”

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confidence: 99%

Electric fields stimulate DNA synthesis of mouse osteoblast‐like cells (MC3T3‐E1) by a mechanism involving calcium ions

Ozawa

Abe

Shibasaki

et al. 1989

Journal Cellular Physiology

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A cell culture system was designed to study the effect of an electric field on bone cells. This system subjected cultured bone cells to a series of high-voltage pulses at varying amplitudes of electric field without changing the ion concentrations of the culture medium. When mouse osteoblast-like cells (MC3T3-E1) were stimulated for 5 min to 20 hr by an electric field (3.19 kV/m, 3 msec, 10 Hz pulses), DNA synthesis was greatly increased. The stimulation occurred only during the growth phase. The electric field also increased incorporation of 45Ca into the cells, but it did not stimulate cAMP production. Adding calcium ionophore A23187 stimulated both 45Ca uptake and DNA synthesis, but dibutyryl cAMP did not stimulate either of them. These results suggest that the electric field stimulates the DNA synthesis of growing osteoblasts by a mechanism involving calcium ions.

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mentioning

confidence: 99%

Electric fields stimulate DNA synthesis of mouse osteoblast‐like cells (MC3T3‐E1) by a mechanism involving calcium ions

Ozawa

Abe

Shibasaki

et al. 1989

Journal Cellular Physiology

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The Problem of the Treatment of Fracture in Long Bone

Cited by 1 publication

References 0 publications

Electric fields stimulate DNA synthesis of mouse osteoblast‐like cells (MC3T3‐E1) by a mechanism involving calcium ions

Electric fields stimulate DNA synthesis of mouse osteoblast‐like cells (MC3T3‐E1) by a mechanism involving calcium ions

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