Resilience and Security are very important attributes for most enterprise Information Systems (IS). These systems have human users with various capabilities, experiences and behaviors. Therefore, they have to be resilient, secure and usable. Resilience requires the capacity to prepare and adapt, facing perpetuating evolutionary conditions, and to restore full capability after an incident or an attack. We track and solve Resilience, Security and Usability issues jointly in Enterprise IS. This challenge requires considering the ergonomics of interactions, effectiveness and efficiency of the task realization, user satisfaction, and trust as well as human feelings when using the secure services. In this paper, we propose an approach based on paradigms of socio-technical systems to model the interplay between resilience, security and usability. We detail a case study illustrating the proposed approach and detailing the elaboration of user-experience-based design patterns.