The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats

Kamiya, Erika; Morita, Akane; Mori, Akira; Sakamoto, Kenji; Nakahara, Tsutomu

doi:10.1016/j.mvr.2022.104455

Cited by 6 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pericytes increase microvascular stability by transforming growth factor‐β (TGF‐β) signaling pathway. One previous study indicated that changes in the shape and distribution of pericytes occurred before the initiation of capillary endothelial cell degeneration and capillary regression in diabetic retinopathy, which further confirmed the protective effect of pericytes on ECs 17 …”

Section: Pluripotency Of Cellssupporting

confidence: 52%

“…3 Unsurprisingly, pericytes are also widely distributed around retinal capillaries, where they regulate the diameter of retinal capillaries through their vasomotor activity, and transmit vasomotor signals to neighboring pericytes along the capillaries. 17,18 In the microvascular system of the spinal cord, studies have shown that PDGFRβ + pericytes break away from the vascular wall following spinal cord injury, transform into fibroblasts, and form scars. Blocking the PDGF-BB/PDGFRβ signaling pathway with imatinib contributes to functional recovery, fibrosis scars, and reduced inflammation following spinal cord injury.…”

Section: Ori G In and D Is Tributi On Of Peri C Y Te Smentioning

confidence: 99%

“…One previous study indicated that changes in the shape and distribution of pericytes occurred before the initiation of capillary endothelial cell degeneration and capillary regression in diabetic retinopathy, which further confirmed the protective effect of pericytes on ECs. 17 Pericytes interact with ECs mainly through three types of intercellular junctions: gap junctions, adhesive plaques, and peg-andsocket junctions. Gap junctions are a form of direct connection in which ionic currents and small molecules transmit between the cytoplasm of two adjacent cells.…”

Section: Pericytes and Ecsmentioning

confidence: 99%

“…They may be divided into three subtypes according to their different morphology and region‐specific distribution, namely ensheathing, mesh and thin‐strand pericytes, which function as regulators of blood flow, blood–brain barrier penetration, neuroinflammation, and neuronal activity 3 . Unsurprisingly, pericytes are also widely distributed around retinal capillaries, where they regulate the diameter of retinal capillaries through their vasomotor activity, and transmit vasomotor signals to neighboring pericytes along the capillaries 17,18 . In the microvascular system of the spinal cord, studies have shown that PDGFRβ + pericytes break away from the vascular wall following spinal cord injury, transform into fibroblasts, and form scars.…”

Section: Origin and Distribution Of Pericytesmentioning

confidence: 99%

See 3 more Smart Citations

Biology and function of pericytes in the vascular microcirculation

Huang

et al. 2023

Anim Models and Exp Med

View full text Add to dashboard Cite

Pericytes are the main cellular components of tiny arteries and capillaries. Studies have found that pericytes can undergo morphological contraction or relaxation under stimulation by cytokines, thus affecting the contraction and relaxation of microvessels and playing an essential role in regulating vascular microcirculation. Moreover, due to the characteristics of stem cells, pericytes can differentiate into a variety of inflammatory cell phenotypes, which then affect the immune function. Additionally, pericytes can also participate in angiogenesis and wound healing by interacting with endothelial cells in vascular microcirculation disorders. Here we review the origin, biological phenotype and function of pericytes, and discuss the potential mechanisms of pericytes in vascular microcirculation disorders, especially in pulmonary hypertension, so as to provide a sound basis and direction for the prevention and treatment of vascular microcirculation diseases.

show abstract

Section: Pluripotency Of Cellssupporting

confidence: 52%

Section: Ori G In and D Is Tributi On Of Peri C Y Te Smentioning

confidence: 99%

Section: Pericytes and Ecsmentioning

confidence: 99%

Section: Origin and Distribution Of Pericytesmentioning

confidence: 99%

See 2 more Smart Citations

Biology and function of pericytes in the vascular microcirculation

Huang

et al. 2023

Anim Models and Exp Med

View full text Add to dashboard Cite

show abstract

“…Proposed mechanisms of the peripheral vascular pathology induced by DM mainly include increased arterial stiffness, endothelial dysfunction, downregulation of vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR), decreased number and function of endothelial progenitor cells (EPCs) and microthrombus formation, etc. (He et al, 2016; Kamiya et al, 2023; Kumar et al, 2021; Wang et al, 2018); thus, medicines that can target those mechanisms may have a therapeutic effectiveness on diabetic wound healing.…”

Section: Beneficial Effects and Underlying Mechanisms Of Resveratrol ...mentioning

confidence: 99%

The protective role of resveratrol in diabetic wound healing

Bi,

Qin,

Wang

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Diabetic wounds are severe complications of diabetes mellitus (DM), which have difficulty in healing. Although diverse treatments have been used, the prognosis of diabetic wounds is not satisfactory; therefore, an effective therapy to accelerate diabetic wound healing is urgently needed. In our review, we summarized that resveratrol can promote diabetic wound healing by protecting against hyperglycemia, inflammation, oxidative stress, vascular pathology, infection, and peripheral neuropathy. To clarify it clearly, we highlighted its underlying mechanisms of protective effects of resveratrol against diabetic wounds, and high‐quality studies are needed to firmly establish its clinical efficacy. Otherwise, with the development of material sciences, resveratrol can exert its therapeutic effectiveness efficiently; however, more high‐quality studies are needed to confirm the clinical efficacy of resveratrol on diabetic wounds.

show abstract